Zobrazeno 1 - 10 of 104 pro vyhledávání: '"Jeff B, Smaill"'
1
Akademický článek
Structural Evaluation of a Nitroreductase Engineered for Improved Activation of the 5-Nitroimidazole PET Probe SN33623
Autor: Abigail V. Sharrock, Jeff S. Mumm, Elsie M. Williams, Narimantas Čėnas, Jeff B. Smaill, Adam V. Patterson, David F. Ackerley, Gintautas Bagdžiūnas, Vickery L. Arcus
Publikováno v: International Journal of Molecular Sciences, Vol 25, Iss 12, p 6593 (2024)
Bacterial nitroreductase enzymes capable of activating imaging probes and prodrugs are valuable tools for gene-directed enzyme prodrug therapies and targeted cell ablation models. We recently engineered a nitroreductase (E. coli NfsB F70A/F108Y) for
Externí odkaz: https://doaj.org/article/35db6809fd4042d9882cc7c017640035
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2
Akademický článek
Tissue Pharmacokinetic Properties and Bystander Potential of Hypoxia-Activated Prodrug CP-506 by Agent-Based Modelling
Autor: Victoria Jackson-Patel, Emily Liu, Matthew R. Bull, Amir Ashoorzadeh, Gib Bogle, Anna Wolfram, Kevin O. Hicks, Jeff B. Smaill, Adam V. Patterson
Publikováno v: Frontiers in Pharmacology, Vol 13 (2022)
Hypoxia-activated prodrugs are bioactivated in oxygen-deficient tumour regions and represent a novel strategy to exploit this pharmacological sanctuary for therapeutic gain. The approach relies on the selective metabolism of the prodrug under patholo
Externí odkaz: https://doaj.org/article/c34ba5238adc4eb49a0ab52ce8b13172
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3
Akademický článek
Interrogation of the Structure–Activity Relationship of a Lipophilic Nitroaromatic Prodrug Series Designed for Cancer Gene Therapy Applications
Autor: Amir Ashoorzadeh, Alexandra M. Mowday, Christopher P. Guise, Shevan Silva, Matthew R. Bull, Maria R. Abbattista, Janine N. Copp, Elsie M. Williams, David F. Ackerley, Adam V. Patterson, Jeff B. Smaill
Publikováno v: Pharmaceuticals, Vol 15, Iss 2, p 185 (2022)
PR-104A is a dual hypoxia/nitroreductase gene therapy prodrug by virtue of its ability to undergo either one- or two-electron reduction to its cytotoxic species. It has been evaluated extensively in pre-clinical GDEPT studies, yet off-target human al
Externí odkaz: https://doaj.org/article/9dcd35635dfd4a64b8e3fee16b54111f
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5
Akademický článek
Restoring Tumour Selectivity of the Bioreductive Prodrug PR-104 by Developing an Analogue Resistant to Aerobic Metabolism by Human Aldo-Keto Reductase 1C3
Autor: Maria R. Abbattista, Amir Ashoorzadeh, Christopher P. Guise, Alexandra M. Mowday, Rituparna Mittra, Shevan Silva, Kevin O. Hicks, Matthew R. Bull, Victoria Jackson-Patel, Xiaojing Lin, Gareth A. Prosser, Neil K. Lambie, Gabi U. Dachs, David F. Ackerley, Jeff B. Smaill, Adam V. Patterson
Publikováno v: Pharmaceuticals, Vol 14, Iss 12, p 1231 (2021)
PR-104 is a phosphate ester pre-prodrug that is converted in vivo to its cognate alcohol, PR-104A, a latent alkylator which forms potent cytotoxins upon bioreduction. Hypoxia selectivity results from one-electron nitro reduction of PR-104A, in which
Externí odkaz: https://doaj.org/article/b19c86e2af6c49538c7e81a3e7b91af6
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6
Akademický článek
Design, Synthesis and In-Vitro Biological Evaluation of Antofine and Tylophorine Prodrugs as Hypoxia-Targeted Anticancer Agents
Autor: Ziad Omran, Chris P. Guise, Linwei Chen, Cyril Rauch, Ashraf N. Abdalla, Omeima Abdullah, Ikhlas A. Sindi, Peter M. Fischer, Jeff B. Smaill, Adam V. Patterson, Yuxiu Liu, Qingmin Wang
Publikováno v: Molecules, Vol 26, Iss 11, p 3327 (2021)
Phenanthroindolizidines, such as antofine and tylophorine, are a family of natural alkaloids isolated from different species of Asclepiadaceas. They are characterized by interesting biological activities, such as pronounced cytotoxicity against diffe
Externí odkaz: https://doaj.org/article/c9e24773f32e4df19e750c5e5c98a534
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