Výsledky vyhledávání - "Jeff Hutchins"

Akademický článek

Stable nebulization and muco‐trapping properties of regdanvimab/IN‐006 support its development as a potent, dose‐saving inhaled therapy for COVID‐19

Autor: Morgan D. McSweeney, Ian Stewart, Zach Richardson, Hyunah Kang, Yoona Park, Cheolmin Kim, Karthik Tiruthani, Whitney Wolf, Alison Schaefer, Priya Kumar, Harendra Aurora, Jeff Hutchins, Jong Moon Cho, Anthony J. Hickey, Soo Young Lee, Samuel K. Lai

Publikováno v: Bioengineering & Translational Medicine, Vol 8, Iss 1, Pp n/a-n/a (2023)

Abstract The respiratory tract represents the key target for antiviral delivery in early interventions to prevent severe COVID‐19. While neutralizing monoclonal antibodies (mAb) possess considerable efficacy, their current reliance on parenteral do

Externí odkaz: https://doaj.org/article/690a48d647804603ba7fe97d886a266d

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Stable nebulization and muco‐trapping properties of regdanvimab/ IN ‐006 support its development as a potent, dose‐saving inhaled therapy for COVID ‐19

Autor: Morgan McSweeney, Ian Stewart, Zach Richardson, Hyunah Kang, Yoona Park, Cheolmin Kim, Karthik Tiruthani, Whitney Wolf, Alison Schaefer, Priya Kumar, Harendra Aurora, Jeff Hutchins, Jong Moon Cho, Anthony J. Hickey, Soo Young Lee, Samuel Lai

Publikováno v: Bioengineering & Translational Medicine. 8

The respiratory tract represents the key target for antiviral delivery in early interventions to prevent severe COVID-19. While neutralizing monoclonal antibodies (mAb) possess considerable efficacy, their current reliance on parenteral dosing necess

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff9aeda80e6a9f0f10ef88b246fd56e5
https://doi.org/10.1002/btm2.10391

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A randomized, double-blind, Phase 1 study of IN-006, an inhaled antibody treatment for COVID-19

Autor: Thomas R. Moench, Lakshmi Botta, Brian Farrer, Jason D. Lickliter, Hyunah Kang, Yoona Park, Cheolmin Kim, Marshall Hoke, Miles Brennan, Morgan D. McSweeney, Zachary Richardson, John B. Whelan, Jong Moon Cho, Soo Young Lee, Frances Faurot, Jeff Hutchins, Samuel K. Lai

RationaleAlthough COVID-19 is predominantly a respiratory tract infection, current antibody treatments are administered by systemic dosing. We hypothesize that inhaled delivery of a muco-trapping monoclonal antibody would provide a more effective and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2f50381f720d81c82120571a038475f2
https://doi.org/10.1101/2022.08.17.22278748

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Abstract 604: PTX-35, a potential first-in-class TNFRSF25 agonist, reduced the suppressive activity of regulatory T cells and enhanced CD4+ T cell effector responses, in the presence of tumor antigens, in a murine melanoma model

Autor: Eric P. Dixon, Vikas Tahiliani, Matthew M. Seavey, Anh M. Trinh, Rahul R. Jasuja, Khalid W. Kalim, Jayalakshmi Miriyala, Jeff Hutchins, Patrick Dillon, Abra N. Chaney

Publikováno v: Cancer Research. 81:604-604

Tumor cells evolve multiple mechanisms to escape immune surveillance, one of which is to establish a tolerogenic microenvironment by recruiting immune suppressive cell types such as regulatory T cells (Tregs). Tumor Necrosis Factor Receptor Super Fam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::42be20aa188af773a7869c847eed6e92
https://doi.org/10.1158/1538-7445.am2021-604

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Phosphatidylserine Sensing by TAM Receptors Regulates AKT-Dependent Chemoresistance and PD-L1 Expression

Publikováno v: Mol Cancer Res

Tyro3, Axl, and Mertk (collectively TAM receptors) are three homologous receptor tyrosine kinases that bind vitamin K–dependent endogenous ligands, Protein S (ProS), and growth arrest–specific factor 6 (Gas6), and act as bridging molecules to pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a00038ee8f56c5734be697b9e4c4bc8
https://doi.org/10.1158/1541-7786.mcr-16-0350

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Phosphatidylserine is a global immunosuppressive signal in efferocytosis, infectious disease, and cancer

Autor: Raymond B. Birge, Sushil Kumar, Xianming Huang, Sebastian Boeltz, J. Wanderley, M. Barcinski, Georg Schett, Alan J. Schroit, David Calianese, Martin Herrmann, Jeff Hutchins, Rolf A. Brekken, Cyril Empig, J. Carlson, Bruce Freimark, Jason Mercer

Publikováno v: Cell Death and Differentiation

Apoptosis is an evolutionarily conserved and tightly regulated cell death modality. It serves important roles in physiology by sculpting complex tissues during embryogenesis and by removing effete cells that have reached advanced age or whose genomes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bbe2594c8ba290d5f4acc54d6000c49
https://doi.org/10.1038/cdd.2016.11

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Abstract P2-04-12: Targeting of phosphatidylserine by monoclonal antibodies enhances the activity of immune checkpoint lag3 targeting antibodies in murine breast tumors

Autor: Bruce Freimark, Jian Gong, Jeff Hutchins, Michael J. Gray

Publikováno v: Cancer Research. 77:P2-04

Previous preclinical modeling has demonstrated that antibodies targeting the programmed cell death ligand 1 (PD-1) have activity in murine breast cancers (BC), and this activity is significantly enhanced when combined with phosphatidylserine (PS) tar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e6769f36e662cc40c6ce9ab10349cd99
https://doi.org/10.1158/1538-7445.sabcs16-p2-04-12

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Abstract 2224A: A novel TNFRSF25 agonist, PTX35, synergizes with Gp96-Ig/OX40L-Ig to enhance effector and memory anti-tumor CD8+ T cell responses and delay tumor growth

Autor: Rahul R. Jasuja, Anh M. Trinh, Jeff Hutchins, Patrick Dillon, Matthew M. Seavey, Vikas Tahiliani, Jayalakshmi Miriyala

Publikováno v: Cancer Research. 80:2224A-2224A

We have developed a next generation cellular vaccine platform that incorporates a tumor antigen chaperone (gp96-Ig) in a tumor cell line and a host of over-expressed cancer associated neoantigens. Viagenpumatucel-L (HS-110), a human lung adenocarcino

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dff59bde585a8903bca92d4df29c6620
https://doi.org/10.1158/1538-7445.am2020-2224a

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Tumor antigen expression and survival of patients with previously treated advanced non-small cell lung cancer (NSCLC) receiving viagenpumatucel-L (HS-110) plus nivolumab

Autor: Daniel Morgensztern, Brian D. Piening, David H Taylor, Fred L. Robinson, Lyudmila Bazhenova, Saiama N. Waqar, Wael A. Harb, Lori McDermott, Jeff Hutchins, Roger B. Cohen, Nathan A. Pennell, Alexa K Dowdell

Publikováno v: Journal of Clinical Oncology. 38:9546-9546

9546 Background: Viagenpumatucel-L (HS-110) is an allogeneic cellular vaccine derived from a human lung adenocarcinoma cell line transfected with gp96-Ig fusion protein. Gp96-Ig functions as an antigen chaperone for dendritic cell activation and dire

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ac887b88d1a928de941e2c619ef94298
https://doi.org/10.1200/jco.2020.38.15_suppl.9546

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