The 5p15.33 locus is associated with risk of lung adenocarcinoma in never-smoking females in Asia.

Autor: Chao Agnes Hsiung, Qing Lan, Yun-Chul Hong, Chien-Jen Chen, H Dean Hosgood, I-Shou Chang, Nilanjan Chatterjee, Paul Brennan, Chen Wu, Wei Zheng, Gee-Chen Chang, Tangchun Wu, Jae Yong Park, Chin-Fu Hsiao, Yeul Hong Kim, Hongbing Shen, Adeline Seow, Meredith Yeager, Ying-Huang Tsai, Young Tae Kim, Wong-Ho Chow, Huan Guo, Wen-Chang Wang, Sook Whan Sung, Zhibin Hu, Kuan-Yu Chen, Joo Hyun Kim, Ying Chen, Liming Huang, Kyoung-Mu Lee, Yen-Li Lo, Yu-Tang Gao, Jin Hee Kim, Li Liu, Ming-Shyan Huang, Tae Hoon Jung, Guangfu Jin, Neil Caporaso, Dianke Yu, Chang Ho Kim, Wu-Chou Su, Xiao-Ou Shu, Ping Xu, In-San Kim, Yuh-Min Chen, Hongxia Ma, Min Shen, Sung Ick Cha, Wen Tan, Chin-Hao Chang, Jae Sook Sung, Mingfeng Zhang, Tsung-Ying Yang, Kyong Hwa Park, Jeff Yuenger, Chih-Liang Wang, Jeong-Seon Ryu, Yongbing Xiang, Qifei Deng, Amy Hutchinson, Jun Suk Kim, Qiuyin Cai, Maria Teresa Landi, Chong-Jen Yu, Ju-Yeon Park, Margaret Tucker, Jen-Yu Hung, Chien-Chung Lin, Reury-Perng Perng, Paolo Boffetta, Chih-Yi Chen, Kun-Chieh Chen, Shi-Yi Yang, Chi-Yuan Hu, Chung-Kai Chang, Joseph F Fraumeni, Stephen Chanock, Pan-Chyr Yang, Nathaniel Rothman, Dongxin Lin

Publikováno v: PLoS Genetics, Vol 6, Iss 8 (2010)

Genome-wide association studies of lung cancer reported in populations of European background have identified three regions on chromosomes 5p15.33, 6p21.33, and 15q25 that have achieved genome-wide significance with p-values of 10(-7) or lower. These

Externí odkaz: https://doaj.org/article/dc0e6a81b20541ca8fb3e553b1cd23e6

Genetic variants in fas signaling pathway genes and risk of gastric cancer

Autor: William Wheeler, Carol Giffen, Shih-Wen Lin, Philip R. Taylor, Jeff Yuenger, Chaoyu Wang, Paula L. Hyland, Kai Yu, Zhaoming Wang, Xiaoqin Xiong, Nan Hu, Hua Su, Han Zhang, Margaret A. Tucker, Ti Ding, Sanford M. Dawsey, Christian C. Abnet, Stephen J. Chanock, Alisa M. Goldstein, Jin-Hu Fan, Neal D. Freedman, Laurie Burdett, Lemin Wang, You-Lin Qiao, Ze Zhong Tang

Publikováno v: International Journal of Cancer. 134:822-831

Populations in north central China are at high risk for gastric cancers (GC), and altered FAS-mediated cell signaling and/or apoptosis may contribute to this risk. We examined the association of 554 single nucleotide polymorphisms (SNPs) in 53 Fas si

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0e943f2f391b5e747c8d690e99efa532
https://doi.org/10.1002/ijc.28415

Genotypic variants at 2q33 and risk of esophageal squamous cell carcinoma in China: a meta-analysis of genome-wide association studies

Autor: Jie Chen, Zhiguo Chen, Zhi Chao Hou, Kevin B. Jacobs, Hong Li Lin, Sanford M. Dawsey, Maxwell P. Lee, Ilyar Sheyhidin, Ying Fa Zhou, Zi Ming Dong, Chang Wei Feng, Dong Xie, Ji Lin Li, Jing Jing Han, Fu Bao Chang, Yu Liu, Li Guo, Wei Zheng, Xiu Feng Yang, Lian Qun Zhang, Ai Fang Ji, Xin Song, Xiu-Min Li, Xiao Shan Feng, Hong Lei Li, Qin Xian Zhang, Tian Yun Wang, Zhaoming Wang, Song Liang Qiu, Dongyun Zhang, Li-Dong Wang, Sa Tang, Er Tao Guo, Ling Yuan, Zhi Gang Guo, Feng Li, Wu Wei, Xuejun Zhang, Jiang Man Li, Guang Yan Lei, Qi Zhou, Xia Yang, Guo Lan Xing, Linda M. Liao, Xian Bo Zuo, Zeng Lin Fan, Jia Chang, Min Han, Yan Rui Zhang, William Wheeler, Woon-Puay Koh, Amy Hutchinson, Ze Zhong Tang, Jian-Min Yuan, Jing Liu, Wen Yan Cui, Xi Chen, Xian Zeng Wang, Zhou Wang, Kai Yu, Xue Min Li, Jin Sheng Wang, Hai Liu, Joseph F. Fraumeni, Yin Li, Fu You Zhou, Yue Wu, Li Wang, Wan Li Yin, Chang Dong Lu, Lei Fan, Laurie Burdett, Ya-Li Liu, Bao Ping Chen, Zhong Min Fan, Liang Wang, Wong Ho Chow, Fu Sheng Gao, Yan Li, Long Qi Chen, Ran Wang, Fu Guo Zhu, Chao Yuan, Tai Jing Liu, Min Liu, Xiao-Ou Shu, Margaret A. Tucker, Zhi Qin Bao, Zhi Cai Liu, Li Yan Xu, Ti Ding, Jian Wei Kul, Shu Wei Ren, Xiang Zhuang, Stephen J. Chanock, Xian Chang Li, Zhi Yong Wu, Dan Li, Ji Li Chen, Jin Cheng Dong, Jing-Li Ren, Jian Xue Yang, Ai Li Li, Yi Ming Mao, Sheng Li Zhou, Chaoyu Wang, You-Lin Qiao, Zhi Qing Yuan, Wei Zhang, Xue Ke Zhao, Jeff Yuenger, She Gan Gao, Qing-Peng Kong, Charles C. Chung, Nan Hu, Bin Liu, Peng Zhang, Yong-Bing Xiang, Jin Wang, Wei Peng Wang, Carol Giffen, Hai Lin Liu, Yan Long Hu, Alisa M. Goldstein, Liangdan Sun, Lu Wen Wang, Jian Ting Zhao, Shuqing Chen, Wen Jing Fu, Sin Yong Lian, Wen Jun Yang, Christian C. Abnet, Jing Huang, Ming Guo, Wen Liang Zhu, Xin Ying Jian, Liu Qin Yang, Xue Pin Fan, Wen Bin Yue, Wancai Yang, Jin Yan, Ping Tao, Yuan Yuan, Jia Huang, Jin Chang Wei, En Min Li, Jin-Hu Fan, Neal D. Freedman, Qirenwang Qige, Guo Shun Ma, Yuan Fang Chen, Xiu Qin Peng, Yu Tang Gao, Philip R. Taylor, Meredith Yeager, Gao Fu Zhang, Jian Po Wang, Jian Jun Miao, Ji Li Cui, Jun Yan Hong

Publikováno v: Human Molecular Genetics. 21:2132-2141

Genome-wide association studies have identified susceptibility loci for esophageal squamous cell carcinoma (ESCC). We conducted a meta-analysis of all single-nucleotide polymorphisms (SNPs) that showed nominally significant P-values in two previously

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::948d39ecb3b62c4fe9638be118f48f03
https://doi.org/10.1093/hmg/dds029

Genetic variation in Th1/Th2 pathway genes and risk of non-Hodgkin lymphoma: a pooled analysis of three population-based case-control studies

Autor: Patricia Hartge, Tongzhang Zheng, Mark P. Purdue, Wendy Cozen, Claire M. Vajdic, Anne Kricker, Jeff Yuenger, Theodore R. Holford, Qing Lan, Maryjean Schenk, Lindsay M. Morton, James R. Cerhan, Richard K. Severson, Idan Menashe, Yawei Zhang, Sophia S. Wang, Stephen J. Chanock, Nilanjan Chatterjee, Shelia Hoar Zahm, Andrew E. Grulich, Brian P. Leaderer, Nathaniel Rothman, Bruce K. Armstrong, Meredith Yeager

Publikováno v: British Journal of Haematology. 153:341-350

The balance between T-helper 1 (Th1) and T-helper 2 (Th2) activity is critical in lymphoid cell development and differentiation. Immune dysfunction underlies lymphomagenesis, so an alteration in the regulation of key Th1/Th2 cytokines may lead to the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0d1b8cd2a43648bdc9c04609c0b95ce9
https://doi.org/10.1111/j.1365-2141.2010.08424.x

A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma

Autor: Stephen J. Chanock, Chaoyu Wang, Zhaoming Wang, Nan Hu, Woon-Puay Koh, Carol Giffen, Ze Zhong Tang, Margaret A. Tucker, Ti Ding, Jin-Hu Fan, Joseph F. Fraumeni, Neal D. Freedman, Yu-Tang Gao, Philip R. Taylor, William Wheeler, Meredith Yeager, Yong-Bing Xiang, Sanford M. Dawsey, Jeff Yuenger, Maxwell P. Lee, Kevin B. Jacobs, Kai Yu, Xiao-Ou Shu, Wei Zheng, Mitchell H. Gail, Wong Ho Chow, Linda M. Dong, Jian-Min Yuan, You-Lin Qiao, Laurie Burdett, Christian C. Abnet, Alisa M. Goldstein, Amy Hutchinson

Publikováno v: Nature Genetics. 42:764-767

Christian Abnet and colleagues report genome-wide association studies for gastric adenocarcinoma and esophageal squamous cell carcinoma in a Chinese population. They identified a new shared risk locus in the PLCE1 gene at 10q23.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fab3ab37c56da3b22f55588b40dd9906
https://doi.org/10.1038/ng.649