Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Jeff, Habel"'
1
The crystal structure of the Rv0301-Rv0300 VapBC-3 toxin-antitoxin complex from M. tuberculosis reveals a Mg2+ ion in the active site and a putative RNA-binding site
Autor: Duilio Cascio, Michael R. Sawaya, Andrew B Min, David Eisenberg, Linda Miallau, Jeff Habel
Publikováno v: Protein Science. 21:1754-1767
VapBC pairs account for 45 out of 88 identified toxin-antitoxin (TA) pairs in the Mycobacterium tuberculosis (Mtb) H37Rv genome. A working model suggests that under times of stress, antitoxin molecules are degraded, releasing the toxins to slow the m
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::226418ac0412e6292bbf49cdbc080f22
https://doi.org/10.1002/pro.2161
Zobrazit plný text záznamu
2
Structure-Activity Relationships and X-ray Structures Describing the Selectivity of Aminopyrazole Inhibitors for c-Jun N-terminal Kinase 3 (JNK3) over p38
Autor: Yuan Yuan Ling, Weimin Chen, Philip LoGrasso, Youseung Shin, Xinyi Song, Theodore M. Kamenecka, Jeff Habel, Derek R. Duckett, Bozena Frackowiak, Rong Jiang
Publikováno v: Journal of Biological Chemistry. 284(19):12853-12861
c-Jun N-terminal kinase 3alpha1 (JNK3alpha1) is a mitogen-activated protein kinase family member expressed primarily in the brain that phosphorylates protein transcription factors, including c-Jun and activating transcription factor-2 (ATF-2) upon ac
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0345b569e304c28e9a4640ceed5562c
http://www.jbc.org/content/284/19/12853
Zobrazit plný text záznamu
3
The crystal structure of the Rv0301-Rv0300 VapBC-3 toxin-antitoxin complex from M. tuberculosis reveals a Mg²⁺ ion in the active site and a putative RNA-binding site
Autor: Andrew B, Min, Linda, Miallau, Michael R, Sawaya, Jeff, Habel, Duilio, Cascio, David, Eisenberg
Publikováno v: Protein science : a publication of the Protein Society. 21(11)
VapBC pairs account for 45 out of 88 identified toxin-antitoxin (TA) pairs in the Mycobacterium tuberculosis (Mtb) H37Rv genome. A working model suggests that under times of stress, antitoxin molecules are degraded, releasing the toxins to slow the m
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3a695c4b63e77402542239e1cb774088
https://pubmed.ncbi.nlm.nih.gov/23011806
Zobrazit plný text záznamu
4
Expression, purification and preliminary crystallographic analysis of O-acetylhomoserine sulfhydrylase from Mycobacterium tuberculosis
Autor: Chang-Yub Kim, Katherine S. Bateman, Li-Wei Hung, Heungbok Kim, Craig R. Garen, Minmin Yu, Michael N.G. James, Emily Alipio Lyon, Jiang Yin, Jeff Habel
The gene product of the open reading frame Rv3340 from Mycobacterium tuberculosis is annotated as encoding a probable O-acetylhomoserine (OAH) sulfhydrylase (MetC), an enzyme that catalyzes the last step in the biosynthesis of methionine, which is an
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f62579073e19a7fecca8d42cb8a5a099
https://europepmc.org/articles/PMC3151138/
Zobrazit plný text záznamu
5
Synthesis and SAR of piperazine amides as novel c-jun N-terminal kinase (JNK) inhibitors
Autor: Tomas Vojkovsky, Philip LoGrasso, Marcel Koenig, Weiming Chen, Theodore M. Kamenecka, Youseung Shin, Derek R. Duckett, Yuanjun He, Jeff Habel, Yuan Yuan Ling
A novel series of c-jun N-terminal kinase (JNK) inhibitors were designed and developed from a high-throughput-screening hit. Through the optimization of the piperazine amide 1, several potent compounds were discovered. The X-ray crystal structure of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0985e79cd3ab7987c861850cab421168
https://europepmc.org/articles/PMC2737472/
Zobrazit plný text záznamu
7
3,5-Disubstituted quinolines as novel c-Jun N-terminal kinase inhibitors
Autor: Philip LoGrasso, Rong Jiang, Weiming Chen, Jeff Habel, Theodore M. Kamenecka, Yuan Yuan Ling, Derek R. Duckett
Publikováno v: Bioorganicmedicinal chemistry letters. 17(22)
The structure-based design and synthesis of a novel series of c-Jun N-terminal kinase (JNK) inhibitors with selectivity against p38 is reported. The unique structure of 3,5-disubstituted quinolines (2) was developed from the previously reported 4-(2,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43f7dab0d0899418190772a38512d511
https://pubmed.ncbi.nlm.nih.gov/17911023
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje