Výsledky vyhledávání - "Jef. J. Emeis"

Dietary sphingolipids lower plasma cholesterol and triacylglycerol and prevent liver steatosis

Autor: Louis M. Havekes, Peter J. Voshol, Wim van Duyvenvoorde, Patrick C.N. Rensen, Willem Nieuwenhuizen, Jef J. Emeis, Ilse Duivenvoorden, Johannes A. Romijn

Publikováno v: European Journal of Lipid Science and Technology. 109:994-997

The prevalence of dyslipidemia and obesity resulting from excess energy intake and physical inactivity is increasing. The liver plays a pivotal role in the systemic lipid homeostasis. Effective, natural dietary interventions that lower plasma lipids

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a6ccac97dc7ec078d77c39864a18fbc7
https://doi.org/10.1002/ejlt.200600250

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THE EFFECTS OF THE FIBRIN-DERIVED PEPTIDE B??15-42 IN ACUTE AND CHRONIC RODENT MODELS OF MYOCARDIAL ISCHEMIA-REPERFUSION

Autor: Kai Zacharowski, Olaf Boehm, Jef J. Emeis, Paula A. Zacharowski, Sonja Reingruber, Peter Friedl, Peter Petzelbauer, Alexander Koch, Rainer Henning, Parissa Mastan, Russell P. Rother

Publikováno v: Shock. 27:631-637

Many compounds have been shown to prevent reperfusion injury in various animal models, although to date, translation into clinic has revealed several obstacles. Therefore, the National Heart, Lung, and Blood Institute convened a working group to disc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b5dcbe784dfc1e4fe862a5ba667b00d
https://doi.org/10.1097/shk.0b013e31802fa038

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Interaction of an annexin V homodimer (Diannexin) with phosphatidylserine on cell surfaces and consequent antithrombotic activity

Autor: Anthony C. Allison, Sandra Larkin, Jef J. Emeis, Frans A. Kuypers

Publikováno v: Thrombosis and Haemostasis. 97:478-486

SummaryAnnexin V(AV), a protein with anticoagulant activity, exerts antithrombotic activity by binding to phosphatidylserine (PS), inhibiting activation of serine proteases important in blood coagulation. The potential use of this protein as an antic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ce7d6a18f288b77b35ad13918012d484
https://doi.org/10.1160/th06-08-0436

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Dual PPARα/γ Agonist Tesaglitazar Reduces Atherosclerosis in Insulin-Resistant and Hypercholesterolemic ApoE*3Leiden Mice

Autor: Louis M. Havekes, Jef J. Emeis, Bart J.M. van Vlijmen, Teake Kooistra, A. Susanne M. Zadelaar, Lianne S.M. Boesten, Germán Camejo, Erik Lundholm, J. Wouter Jukema

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 26:2560-2566

OBJECTIVE - We investigated whether the dual PPARα/γ agonist tesaglitazar has anti-atherogenic effects in ApoE*3Leiden mice with reduced insulin sensitivity. METHODS AND RESULTS - ApoE*3Leiden transgenic mice were fed a high-fat (HF) insulin-resist

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4684fcae148b56c0ee9f28b426bb7c78
https://doi.org/10.1161/01.atv.0000242904.34700.66

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Dietary sphingolipids lower plasma cholesterol and triacylglycerol and prevent liver steatosis in APOE*3Leiden mice1–3

Autor: Wim van Duyvenvoorde, Ilse Duivenvoorden, Jef J. Emeis, Peter J. Voshol, Louis M. Havekes, Patrick C.N. Rensen, Johannes A. Romijn, Willem Nieuwenhuizen

Publikováno v: The American Journal of Clinical Nutrition. 84:312-321

Background: The prevalence of dyslipidemia and obesity resulting from excess energy intake and physical inactivity is increasing. The liver plays a pivotal role in systemic lipid homeostasis. Effective, natural dietary interventions that lower plasma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a9d9444a34f5d00fdd59df5cf1244df6
https://doi.org/10.1093/ajcn/84.1.312

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Anti-atherosclerotic effect of amlodipine, alone and in combination with atorvastatin, in APOE*3-Leiden/hCRP transgenic mice

Autor: E.H. Offerman, Astrid Trion, Arnoud van der Laarse, Wouter Jukema, Moniek P.M. de Maat, Louis M. Havekes, Jef J. Emeis, Annemarie C.E. Maas, Hans M.G. Princen, Alexander J. Szalai

Publikováno v: Journal of Cardiovascular Pharmacology, 47(1), 89-95. Lippincott Williams & Wilkins

We investigated the pleiotropic effects of a calcium antagonist (amlodipine) on early atherosclerosis development in the presence and absence of an HMG-CoA-reductase inhibitor (atorvastatin) in apolipoprotein E*3-Leiden/human C-reactive protein (E3L/

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32d618f86de1868eedf48e69e781527b
https://pure.eur.nl/en/publications/5cceaca9-8b87-4080-8620-e719983fd713

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The effects of 12 weeks of HMR 3339, a novel selective estrogen receptor modulator, on markers of coagulation and fibrinolysis: a randomized, placebo-controlled, double-blind, dose-ranging study in healthy postmenopausal women

Autor: Tatjana E. Vogelvang, Marius J. van der Mooren, Peter Kenemans, Jef J. Emeis, Johannes A. Heijst, Velja Mijatovic

Publikováno v: American Journal of Obstetrics and Gynecology, 4, 193, 1384-1394
Vogelvang, T E, Mijatovic, V, Kenemans, P, Emeis, J J, Heijst, J A & van der Mooren, M J 2005, ' The effects of 12 weeks of HMR 3339, a novel selective estrogen receptor modulator, on markers of coagulation and fibrinolysis: a randomized, placebo-controlled, double-blind, dose-ranging study in healthy postmenopausal women ', American Journal of Obstetrics and Gynecology, vol. 193, no. 4, pp. 1384-1394 . https://doi.org/10.1016/j.ajog.2005.02.083
American Journal of Obstetrics and Gynecology, 193(4), 1384-1394. Mosby Inc.

Objective: To investigate the short-term effects of HMR 3339, a novel selective estrogen receptor modulator, on markers of coagulation and fibrinolysis. Study design: In a multicenter, 14-week, randomized, placebo-controlled, double-blind, dose-rangi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bab8f043f326fe10c4aa78f4965cd3bd
https://hdl.handle.net/1871/26571

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Increased Urinary Albumin Excretion, Endothelial Dysfunction, and Chronic Low-Grade Inflammation in Type 2 Diabetes

Autor: Hans-Henrik Parving, M. A. Gall, Coen D.A. Stehouwer, Jos W. R. Twisk, Elisabeth Knudsen, Jef J. Emeis

Publikováno v: Diabetes. 51:1157-1165

In 328 type 2 diabetic patients followed for 9.0 years (mean), we investigated whether endothelial dysfunction and chronic inflammation (estimated from plasma markers) can explain the association between (micro)albuminuria and mortality. Of the patie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e8bde53bdc0324a37bedc2d244bf416e
https://doi.org/10.2337/diabetes.51.4.1157

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Progression of diabetic nephropathy: Role of plasma homocysteine and plasminogen activator inhibitor-1

Autor: Coen D.A. Stehouwer, Jef J. Emeis, Tom Teerlink, Hans-Henrik Parving, Lise Tarnow, Peter Rossing, Peter Hovind

Publikováno v: American Journal of Kidney Diseases. 38:1376-1380

Among patients with diabetic nephropathy, the decline in glomerular filtration rate (GFR) varies substantially, ranging from 2 to 20 mL/min per year. Identification of predictors of progression in diabetic nephropathy is important. Plasma total homoc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c10db488ad7bfc073db172fc4362b45
https://doi.org/10.1053/ajkd.2001.29261

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Simvastatin Improves Disturbed Endothelial Barrier Function

Autor: Victor W.M. van Hinsbergh, Jef J. Emeis, Mario A. Vermeer, Jan Lankelma, Pascale Nègre-Aminou, Geerten P. van Nieuw Amerongen

Publikováno v: Circulation. 102:2803-2809

Background —Recent clinical trials have established that inhibitors of the enzyme 3-hydroxy-3-methylglutaryl coenzyme A reductase (statins) reduce the risk of acute coronary events. These effects of statins cannot be fully explained by their lipid-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1afd3309a4cb55bbc0d1bb12d41c148
https://doi.org/10.1161/01.cir.102.23.2803

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