Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Jef Vermeire"'
Autor:
Miroslav Cik, John R. Atack, Paula te Riele, Marcel Frans Leopold De Bruyn, Ria Wouters, Gregor James Macdonald, Jef Vermeire, Herman M. R. Hendrickx, Anton Megens, Luc Peeters, Hilde Lavreysen, Xavier Langlois
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 342:91-105
All marketed antipsychotics act by blocking dopamine D(2) receptors. Fast dissociation from D(2) receptors may be one of the elements contributing to the lower incidence of extrapyramidal symptoms (EPS) exhibited by newer antipsychotics. Therefore, w
Autor:
Anton Megens, Wilhelmus Drinkenburg, Koen A. Hens, Xavier Langlois, Jef Vermeire, Brian Joel Hrupka, John R. Atack, Paul F. Jackson, Kenneth J. Rhodes, Paula te Riele, Annemie L. Y. Wellens, Abdallah Ahnaou, Nancy Aerts, Patrick De Haes, Brian C. Shook, Herman M. R. Hendrickx, Stefanie Rassnick
Publikováno v:
ACS chemical neuroscience. 5(10)
Adenosine A2A antagonists are believed to have therapeutic potential in the treatment of Parkinson’s disease (PD). We have characterized the dual adenosine A2A/A1 receptor antagonist JNJ-40255293 (2-amino-8-[2-(4-morpholinyl)ethoxy]-4-phenyl-5H-ind
Autor:
D. Ashton, Koen A. Hens, J. F. Fransen, L. Heylen, P. C. M. Vermote, M Jurzak, F. Janssens, J. E. Leysen, Jef Vermeire, Anton Megens, M. Mahieu, L. C. Hillen
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 302(2)
In comparison with a series of reference compounds, (2R-trans)-4-[1-[3,5-bis(trifluoromethyl)benzoyl]-2-(phenylmethyl)-4-piperidinyl]-N-(2,6-dimethylphenyl)-1-acetamide (S)-Hydroxybutanedioate (R116301) was characterized as a specific, orally, and ce
Publikováno v:
Journal of pain and symptom management. 15(4)
Clinical studies report a low incidence of intestinal side effects with transdermally administered fentanyl (TTS-fentanyl) in comparison with oral morphine. To support these clinical data, analgesic and intestinal effects of both opioids were compare