Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Jeevan R. Kunta"'
Autor:
Cosette J. Serabjit-Singh, Jarkko Rautio, Lindsey O. Webster, Jeevan R. Kunta, Joseph W. Polli, John P. Keogh, Anand Balakrishnan, Joan E. Humphreys
Publikováno v:
Drug Metabolism and Disposition. 34:786-792
Because modulation of P-glycoprotein (Pgp) through inhibition or induction can lead to drug-drug interactions by altering intestinal, central nervous system, renal, or biliary efflux, it is anticipated that information regarding the potential interac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37b801a72997d3eeb4af00ceb47dd0d4
https://doi.org/10.1124/dmd.105.008615
https://doi.org/10.1124/dmd.105.008615
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 310:359-366
The current study was performed in intestinal and vascular access ported rabbits to quantify and differentiate the components of intestinal and hepatic first pass extraction (i.e., metabolism and secretion) of saquinavir (SQV) mediated by P-glycoprot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bfbd4fef4b10ae1b13f7702fe2e8f56
https://doi.org/10.1124/jpet.103.064394
https://doi.org/10.1124/jpet.103.064394
Autor:
Jeevan R. Kunta, Patrick J. Sinko
Publikováno v:
Current Drug Metabolism. 5:109-124
The oral route of drug administration remains the most popular and convenient route of administration, despite its many shortcomings and challenges. Although the advantages associated with this route far outweigh any limitations, a prominent limitati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::917668aa6f6be5933baf73a34d5cde5f
https://doi.org/10.2174/1389200043489144
https://doi.org/10.2174/1389200043489144
Autor:
John P. Sutyak, Jeevan R. Kunta, Yong-Hee Lee, Hee Sang Lee, Barbara A. Perry, Patrick J. Sinko
Publikováno v:
Pharmaceutical Research. 18:1721-1728
Purpose. To investigate the relative contributions of the gut and liver to the first-pass loss of verapamil (VL) using anin vivo intestinal-vascular access port (IVAP) dog model.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a97bbaabc8c8c1c7f792b5ec5ba81bc
https://doi.org/10.1023/a:1013374630274
https://doi.org/10.1023/a:1013374630274
Publikováno v:
Biopharmaceutics & Drug Disposition. 21:83-93
The aim of the present study was to investigate the directional transport kinetics of etoposide in rabbit intestinal tissues using side-by-side diffusion chambers. Etoposide is a routinely used mixed-mechanism 'efflux' inhibitor; however, its absorpt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::410abd94820cef70f7d2443218ac2942
https://doi.org/10.1002/1099-081x(200004)21:3<83::aid-bdd220>3.0.co
https://doi.org/10.1002/1099-081x(200004)21:3<83::aid-bdd220>3.0.co
Autor:
Jeevan R. Kunta, John P. Keogh
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 27(5)
Regulatory interest is increasing for drug transporters generally and P-glycoprotein (Pgp) in particular, primarily in the area of drug-drug interactions. To aid in both identifying and discharging the potential liabilities associated with drug-trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1897d21aa767ec133b0d4b6646803c6a
https://pubmed.ncbi.nlm.nih.gov/16406207
https://pubmed.ncbi.nlm.nih.gov/16406207
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 32(11)
Low and varied oral bioavailability (BA) of some drugs has been attributed to extraction by the intestine and liver. However, the role of the intestine is difficult to directly assess. We recently developed an in vivo intestinal and vascular access-p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d314f78f337947655312fef12e88ec1
https://pubmed.ncbi.nlm.nih.gov/15304428
https://pubmed.ncbi.nlm.nih.gov/15304428
Publikováno v:
Optimization in Drug Discovery: In Vitro Methods; 2014, pi-xvii, 17p
Autor:
Volpe, Donna
Publikováno v:
AAPS Journal; Oct2010, Vol. 12 Issue 4, p670-678, 9p, 6 Charts, 8 Graphs
Publikováno v:
Pharmaceutical Research; Mar2011, Vol. 28 Issue 3, p421-422, 2p