Výsledky vyhledávání - "Jeesoo, Chae"

Akademický článek

Spatial architectures of somatic mutations in normal prostate, benign prostatic hyperplasia and coexisting prostate cancer

Autor: Jeesoo Chae, Seung-Hyun Jung, Eun Ji Choi, Jae Woong Kim, Na Yung Kim, Sung Won Moon, Ji Youl Lee, Yeun-Jun Chung, Sug Hyung Lee

Publikováno v: Experimental and Molecular Medicine, Vol 56, Iss 1, Pp 168-176 (2024)

Abstract This study aimed to identify somatic mutations in nontumor cells (NSMs) in normal prostate and benign prostatic hyperplasia (BPH) and to determine their relatedness to prostate cancer (PCA). From 22 PCA patients, two prostates were sampled f

Externí odkaz: https://doaj.org/article/e60bd6c7c40448188ca05528b0d67678

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Akademický článek

Predictive biomarkers for 5-fluorouracil and oxaliplatin-based chemotherapy in gastric cancers via profiling of patient-derived xenografts

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)

Gastric cancer is commonly treated by chemotherapy using 5-fluorouracil derivatives and platinum combination, but predictive biomarker remains lacking. Here, the authors develop a 30-gene prediction model to determine the responsiveness to 5-fluorour

Externí odkaz: https://doaj.org/article/08fe478b004a4631b3a74073129531e8

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Akademický článek

S100A8/A9 mediate the reprograming of normal mammary epithelial cells induced by dynamic cell–cell interactions with adjacent breast cancer cells

Autor: Seol Hwa Jo, Woo Hang Heo, Hye-Youn Son, Mingji Quan, Bok Sil Hong, Ju Hee Kim, Han-Byoel Lee, Wonshik Han, Yeonju Park, Dong-Sup Lee, Nam Hoon Kwon, Min Chul Park, Jeesoo Chae, Jong-Il Kim, Dong-Young Noh, Hyeong-Gon Moon

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)

Abstract To understand the potential effects of cancer cells on surrounding normal mammary epithelial cells, we performed direct co-culture of non-tumorigenic mammary epithelial MCF10A cells and various breast cancer cells. Firstly, we observed dynam

Externí odkaz: https://doaj.org/article/ff6cf20ce724434eac10c56824e1daea

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Akademický článek

Amplification of transglutaminase 2 enhances tumor-promoting inflammation in gastric cancers

Publikováno v: Experimental and Molecular Medicine, Vol 52, Iss 5, Pp 854-864 (2020)

Stomach cancer: Enzyme promotes problematic inflammation An enzyme linked to harmful inflammation that promotes tumor growth could be a target for stomach cancer treatment. The expression of the enzyme transglutaminase 2 (TGM2) has been shown to incr

Externí odkaz: https://doaj.org/article/0a1b8d458f4e4111a53bb04c6b09dd48

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Akademický článek

A population-specific low-frequency variant of SLC22A12 (p.W258*) explains nearby genome-wide association signals for serum uric acid concentrations among Koreans.

Autor: Sun-Wha Im, Jeesoo Chae, Ho-Young Son, Belong Cho, Jong-Il Kim, Jin-Ho Park

Publikováno v: PLoS ONE, Vol 15, Iss 4, p e0231336 (2020)

Prolonged hyperuricemia is a cause of gout and an independent risk factor for chronic health conditions including diabetes and chronic kidney diseases. Genome-wide association studies (GWASs) for serum uric acid (SUA) concentrations have repeatedly c

Externí odkaz: https://doaj.org/article/36d14456c4904c7a8206c6d8c8362629

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An integrative approach for exploring the nature of fibroepithelial neoplasms

Autor: Jihui Yun, Woohang Heo, Eun-Shin Lee, Deukchae Na, Wonyoung Kang, Jinjoo Kang, Jeesoo Chae, Dakyung Lee, Woochan Lee, Jinha Hwang, Tae-Kyung Yoo, Bok Sil Hong, Hye-Youn Son, Dong-Young Noh, Charles Lee, Hyeong-Gon Moon, Jong-Il Kim

Publikováno v: British Journal of Cancer. 128:626-637

Background Malignant phyllodes tumour (MPT) is a rare breast malignancy with epithelial and mesenchymal features. Currently, there are no appropriate research models or effective targeted therapeutic approaches for MPT. Methods We collected fresh fro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c22a3b838b376d733a2e9dc3e555c6a1
https://doi.org/10.1038/s41416-022-02064-2

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Supplementary Figures from A Novel Combination Treatment Targeting BCL-XL and MCL1 for KRAS/BRAF-mutated and BCL2L1-amplified Colorectal Cancers

Autor: Charles Lee, Won-Suk Lee, Hansoo Park, Jong-Il Kim, Jeesoo Chae, Jinjoo Kang, Seoyeon Min, Jieun Lee, Jooyoung Kim, Ahra Lee, Wonyoung Kang, Deukchae Na, Jee Yun Han, Sung-Yup Cho

Supplementary Figure S1. Expression of BCL2L1 and BCL2 in CRC cell lines; Supplementary Figure S2. Estimated BCL2L1 copy numbers of CRC patients by droplet digital PCR (ddPCR); Supplementary Figure S3. Screening of MCL1-modulating agents for synergis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0b52d75f7d5f477bc21135611fa17b9
https://doi.org/10.1158/1535-7163.22508200

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Data from Unstable Genome and Transcriptome Dynamics during Tumor Metastasis Contribute to Therapeutic Heterogeneity in Colorectal Cancers

Autor: Jong-Il Kim, Hansoo Park, Won-Suk Lee, Charles Lee, Jeffrey H. Chuang, Chang Ohk Sung, Jieun Lee, Boram Choi, Jinjoo Kang, Seoyeon Min, Ahra Lee, Wonyoung Kang, Deukchae Na, Jeesoo Chae, Sung-Yup Cho

Purpose:Genomic and transcriptomic alterations during metastasis are considered to affect clinical outcome of colorectal cancers, but detailed clinical implications of metastatic alterations are not fully uncovered. We aimed to investigate the effect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28240df6738e1194f01f0cee5fe21f38
https://doi.org/10.1158/1078-0432.c.6528425

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