Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Jeejabai, Radhakrishnan"'
Autor:
Salvatore R. Aiello, Jenna B. Mendelson, Alvin Baetiong, Jeejabai Radhakrishnan, Raúl J. Gazmuri
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 23 (2021)
Background We previously reported that resuscitation delivering electrical shocks guided by real‐time ventricular fibrillation amplitude spectral area (AMSA) enabled return of spontaneous circulation (ROSC) with fewer shocks, resulting in less myoc
Externí odkaz:
https://doaj.org/article/daae912a81c04acdb0ee61a183a0da26
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
We have previously reported in HEK 293 T cells and in constitutive cyclophilin-D (Cyp-D) knockout (KO) mice that Cyp-D ablation downregulates oxygen consumption (VO2) and triggers an adaptive response that manifest in higher exercise endurance with l
Externí odkaz:
https://doaj.org/article/5967684383e844338d2f6c4d444e0bb5
Autor:
Jeejabai Radhakrishnan, Rovi Origenes, Gina Littlejohn, Sanja Nikolich, Eunjung Choi, Sharon Smite, Lorissa Lamoureux, Alvin Baetiong, Manoj Shah, Raúl J Gazmuri
Publikováno v:
Biomarker Insights, Vol 12 (2017)
Background: Cytochrome c is an intermembrane mitochondrial protein that is released to the bloodstream following mitochondrial injury. Methods and results: We developed an electrochemiluminescence immunoassay to measure cytochrome c in human and rat
Externí odkaz:
https://doaj.org/article/06dbab84fac147b4b5f15d2ac3baf8ad
Autor:
Salvatore Aiello, Michelle Perez, Chad Cogan, Alvin Baetiong, Steven A. Miller, Jeejabai Radhakrishnan, Christopher L. Kaufman, Raúl J. Gazmuri
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 6, Iss 11 (2017)
BackgroundThe ventricular fibrillation amplitude spectral area (AMSA) predicts whether an electrical shock could terminate ventricular fibrillation and prompt return of spontaneous circulation. We hypothesized that AMSA can guide more precise timing
Externí odkaz:
https://doaj.org/article/d11da0dd51a3424da9141b10e49fa80b
Publikováno v:
Molecules, Vol 24, Iss 9, p 1765 (2019)
Out-of-hospital sudden cardiac arrest is a major public health problem with an overall survival of less than 5%. Upon cardiac arrest, cessation of coronary blood flow rapidly leads to intense myocardial ischemia and activation of the sarcolemmal Na+-
Externí odkaz:
https://doaj.org/article/02d44954ee4f415fba8974741de8cd5f
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0161166 (2016)
Several characteristics of the ventricular fibrillation (VF) waveform have been found predictive of successful defibrillation and hypothesized to reflect the myocardial energy state. In an open-chest swine model of VF, we modeled "average CPR" using
Externí odkaz:
https://doaj.org/article/54e1be8d5c16414d86e48405548084e3
Publikováno v:
Circulation. 144
We have previously reported in HEK 293T cells and in constitutive cyclophilin-D (Cyp-D) knock-out (KO) mice that Cyp-D ablation downregulates oxygen consumption (VO 2 ) and triggers an adaptive response that manifests in higher exercise endurance wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af3199d8f03d1ac7dce2c89d2f0f2732
https://doi.org/10.1161/circ.144.suppl_2.11036
https://doi.org/10.1161/circ.144.suppl_2.11036
Publikováno v:
Circulation. 144
Introduction: VF accounts for ~30% of all sudden cardiac arrest episodes. VF signal analysis in the frequency domain - calculating the amplitude spectral area (AMSA) - can inform on the probability that an electrical shock could terminate VF followed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1b815680041be781871426b8a826c25
https://doi.org/10.1161/circ.144.suppl_2.10911
https://doi.org/10.1161/circ.144.suppl_2.10911
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0130134 (2015)
Current management of hemorrhagic shock (HS) in the battlefield and civilian settings favors small-volume fluid resuscitation before controlling the source of bleeding. We investigated in a swine model of HS the effects of vasopressin infusion along
Externí odkaz:
https://doaj.org/article/8192b9fe242c440a9924682b30df93ce
Autor:
Alvin Baetiong, Joseph X. DiMario, Michelle Huynh, Adriana Maria Fresquez, Raúl J. Gazmuri, Harrison Kaufman, Carl White, Angela Leschinsky, Jeejabai Radhakrishnan
Publikováno v:
The FASEB Journal. 33:11443-11457
We previously reported in HEK 293T cells that silencing the mitochondrial peptidyl prolyl isomerase cyclophilin-D (Cyp-D) reduces Vo2. We now report that in vivo Cyp-D ablation using constitutive Cyp-D knockout (KO) mice also reduces Vo2 both at rest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56643c256ac742d937de2764059834a8
https://doi.org/10.1096/fj.201802238r
https://doi.org/10.1096/fj.201802238r