Zobrazeno 1 - 10
of 114
pro vyhledávání: '"Jeehee, Youn"'
Autor:
Eunkyeong Jang, ChangYeon Kim, Jeonghyun Noh, Hansol Yi, Sungsin Jo, Jin-Sil Park, Woochang Hwang, Ji-Young Cha, Mi-La Cho, Tae-Hwan Kim, Jeehee Youn
Publikováno v:
Cell Reports, Vol 43, Iss 11, Pp 114878- (2024)
Summary: The transcription repressor Bach2 plays a crucial role in shaping humoral immunity, but its cell-autonomous function remains elusive. Here, we reveal the mechanism by which Bach2 regulates effector cell maturation in peripheral B cells. In r
Externí odkaz:
https://doaj.org/article/6a860a8f9487444a8b232efaedba224c
Autor:
Kihyoun Park, Injae Shin, Yoonseon Kim, Hyereen Kang, Soo-Jin Oh, Eunkyeong Jang, Taebo Sim, Jeehee Youn, Myung-Shik Lee
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
BackgroundSince NEK7 is critical for NLRP3 inflammasome activation, NEK7 inhibitors could be employed as therapeutic agents against gout, a representative disease caused by NLRP3 inflammasome.MethodsWe designed NEK7 inhibitors based on biochemical ki
Externí odkaz:
https://doaj.org/article/e54b04d9a99a4f47b6bca4d955a248b0
Publikováno v:
HemaSphere, Vol 7, p e3562913 (2023)
Externí odkaz:
https://doaj.org/article/8f2f8b34e01d41cda9f72b9319db44cc
Autor:
Young-Eun Kim, Jae-Hyun Lee, Eun-Ju Lee, Do Hoon Kim, Mi Ryeong Jeong, Seokchan Hong, Chang-Keun Lee, Bin Yoo, Jeehee Youn, Eun-Ju Chang, Yong-Gil Kim
Publikováno v:
Biomedicines, Vol 11, Iss 10, p 2757 (2023)
Nicotine, an abundant molecule in tobacco, has immunomodulatory effects on inflammatory diseases, primarily due to the activation of alpha7 nicotinic acetylcholine receptor (α7 nAChR). We aim to evaluate the expression of the α7 nAChR+ cells in joi
Externí odkaz:
https://doaj.org/article/fa008de8ef6746e285ad1e61012c4e75
Autor:
Sungsin Jo, Eun-Ju Lee, Bora Nam, Juyeon Kang, Seunghun Lee, Jeehee Youn, Ye-Soo Park, Yong-Gil Kim, Tae-Hwan Kim
Publikováno v:
Arthritis Research & Therapy, Vol 22, Iss 1, Pp 1-7 (2020)
Abstract Background Ankylosing spondylitis (AS) is characteristically male-predominant, and progressive spinal ankylosis affects male patients more severely; however, the hormonal effects in males with AS are poorly understood. Methods In the present
Externí odkaz:
https://doaj.org/article/ed0bd5b52c864f469bd12857af65e7ee
Autor:
Eunkyeong Jang, Un Kyo Kim, Kiseok Jang, Young Soo Song, Ji-Young Cha, Hansol Yi, Jeehee Youn
Publikováno v:
Experimental and Molecular Medicine, Vol 51, Iss 12, Pp 1-13 (2019)
Autoimmune disease: Bach2 orchestrates immune function Bach2, a protein that regulates gene expression, is required in the B cells and T cells of the immune system to protect against autoimmune disease. Bach2 deficiency has previously been associated
Externí odkaz:
https://doaj.org/article/693c5dc5fb704e97bbdeb8bbe5dbb7c6
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Splenic long-lived plasma cells are abnormally numerous and deleterious in systemic autoimmune diseases, yet how they accumulate remains poorly understood. We demonstrate here that a pathological role of spleen-derived CD11b+Gr-1+ myeloid cells (SDMC
Externí odkaz:
https://doaj.org/article/063a5337b889454fa6bd5f813e765b4e
Autor:
Sungsin Jo, Seung Hoon Lee, Jinsung Park, Bora Nam, Hyunsung Kim, Jeehee Youn, Seunghun Lee, Tae‐Jong Kim, Il‐Hoon Sung, Sung Hoon Choi, Ye‐Soo Park, Robert D Inman, Tae‐Hwan Kim
Publikováno v:
Journal of Bone and Mineral Research. 38:300-312
Enthesophyte formation plays a crucial role in the development of spinal ankylosis in ankylosing spondylitis (AS). We aimed to investigate the role of platelet-derived growth factor B (PDGFB) in enthesophyte formation of AS using in vitro and in vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d55814428933346ae06401ec76eaeb55
https://doi.org/10.1002/jbmr.4751
https://doi.org/10.1002/jbmr.4751
Publikováno v:
Clinical and Experimental Immunology. 211:31-45
Spleen tyrosine kinase (Syk) plays a pivotal role in the activation of B cells and innate inflammatory cells by transducing immune receptor-triggered signals. Dysregulated activity of Syk is implicated in the development of antibody-mediated autoimmu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20352a662c55352f49c8917fb34b6e59
https://doi.org/10.1093/cei/uxac096
https://doi.org/10.1093/cei/uxac096
Autor:
Doo-Ho Lim, Eun-Ju Lee, Hee-Seop Lee, Do Hoon Kim, Jae-Hyun Lee, Mi Ryeong Jeong, Seokchan Hong, Chang-Keun Lee, Bin Yoo, Jeehee Youn, Yong-Gil Kim
Publikováno v:
Biomedicines, Vol 9, Iss 9, p 1095 (2021)
Acetylated diacylglycerol 1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol (PLAG) is a lipid molecule from the antlers of sika deer that might reduce inflammation by effectively controlling neutrophil infiltration, endothelial permeability and inflammat
Externí odkaz:
https://doaj.org/article/6a4e39fadcd549fb9ce8a68941240781