Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Jee Woong Lim"'
Autor:
Su-Yeon Lee, Sanghwa Kim, Inhee Choi, Yeonhwa Song, Namjeong Kim, Hyung Chul Ryu, Jee Woong Lim, Hyo Jin Kang, Jason Kim, Haeng Ran Seo
Publikováno v:
Cell Death and Disease, Vol 13, Iss 11, Pp 1-11 (2022)
Abstract 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) is a key enzyme that catalyzes the intracellular conversion of cortisone to physiologically active cortisol. Although 11βHSD1 has been implicated in numerous metabolic syndromes, such as o
Externí odkaz:
https://doaj.org/article/36fb516f0e0e4b41a7a98bd1d3942c9d
Autor:
Hyung Chul Ryu, Marc Windisch, Jee Woong Lim, Inhee Choi, Eun Kyu Lee, Hye Hyun Yoo, Tae Kon Kim
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 462-468 (2021)
To develop unique small-molecule inhibitors of hepatitis C virus (HCV), thiophen urea (TU) derivatives were synthesised and screened for HCV entry inhibitory activities. Among them, seven TU compounds exhibited portent anti-viral activities against g
Externí odkaz:
https://doaj.org/article/f0c396f876fc46c69ff6a4c1280f3573
Autor:
Dong Wook Kang, Ju Hee Kim, Kyung Min Kim, Seok-jin Cho, Hee-Woon Jang, Ji Won Chang, Seung Myung Dong, Jee Woong Lim, Jae-Sun Kim, Hea-Young Cho
Publikováno v:
Pharmaceutics, Vol 13, Iss 9, p 1406 (2021)
Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one) is a free radical scavenger approved for the treatment of amyotrophic lateral sclerosis, a fatal neuromuscular disease. Edaravone is administered as an intravenous infusion over 60 min for several treat
Externí odkaz:
https://doaj.org/article/a86deb605e67422a85de7ee80122c8e0
Autor:
Eun Kyu Lee, Tae Kon Kim, Inhee Choi, Hyung Chul Ryu, Marc P. Windisch, Jee Woong Lim, Hye Hyun Yoo
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 462-468 (2021)
To develop unique small-molecule inhibitors of hepatitis C virus (HCV), thiophen urea (TU) derivatives were synthesised and screened for HCV entry inhibitory activities. Among them, seven TU compounds exhibited portent anti-viral activities against g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cb6284ec1aaa1ade7fe5f91d7965901
https://doaj.org/article/f0c396f876fc46c69ff6a4c1280f3573
https://doaj.org/article/f0c396f876fc46c69ff6a4c1280f3573
Autor:
Jae-Sun Kim, Hea-Young Cho, Ji Won Chang, Seung Myung Dong, Jee Woong Lim, Hee-Woon Jang, Ju Hee Kim, Kyungmin Kim, Seok-jin Cho, Dong Wook Kang
Publikováno v:
Pharmaceutics
Pharmaceutics, Vol 13, Iss 1406, p 1406 (2021)
Volume 13
Issue 9
Pharmaceutics, Vol 13, Iss 1406, p 1406 (2021)
Volume 13
Issue 9
Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one) is a free radical scavenger approved for the treatment of amyotrophic lateral sclerosis, a fatal neuromuscular disease. Edaravone is administered as an intravenous infusion over 60 min for several treat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e88830c0527cfd1b36d12bff145d52f7
https://doi.org/10.3390/pharmaceutics13091406
https://doi.org/10.3390/pharmaceutics13091406
Autor:
Jason Kim, Hyeryon Lee, Hyung Chul Ryu, Jee Woong Lim, Sanghwa Kim, Moonhee Kim, Haeng Ran Seo, Yeonhwa Song, Inhee Choi, Joo Hwan No
Publikováno v:
Cancers
Volume 12
Issue 5
Cancers, Vol 12, Iss 1193, p 1193 (2020)
Volume 12
Issue 5
Cancers, Vol 12, Iss 1193, p 1193 (2020)
Hepatocellular carcinoma (HCC) is a highly malignant human cancer that has increasing mortality rates worldwide. Because CD133+ cells control tumor maintenance and progression, compounds that target CD133+ cancer cells could be effective in combating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eebebd80881127a131418a97a916820c
https://doi.org/10.3390/cancers12051193
https://doi.org/10.3390/cancers12051193
Autor:
Misuk Joung, Jee Woong Lim, Chang-Koo Shim, Han-Joo Maeng, Eunseo Kim, Chieyeon Chough, Won-Sik Shim
Publikováno v:
Biopharmaceutics & Drug Disposition. 35:60-69
Anti-cancer agents delivered to cancer cells often show multi-drug resistance (MDR) due to expulsion of the agents. One way to address this problem is to increase the accumulation of anti-cancer agents in cells via amino acid transporters. Thus, val-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc8ba14f60cecce4161978a6ad257838
https://doi.org/10.1002/bdd.1872
https://doi.org/10.1002/bdd.1872
Publikováno v:
Bioorganicmedicinal chemistry letters. 26(22)
The aim of our study was to develop ursolic acid (UA) prodrugs in order to overcome UA's weakness, which has an extremely low bioavailability. UA-medoxomil (NX-201), one of our UA prodrugs, showed an improved bioavailability about 200times better tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61ffbfc311e7f9700fb2ed8f27dd8d40
https://pubmed.ncbi.nlm.nih.gov/27769622
https://pubmed.ncbi.nlm.nih.gov/27769622
Publikováno v:
Bulletin of the Korean Chemical Society. 33:717-720
Chemokines play a crucial role in the trafficking of leukocytes in the body through the binding to their related receptors. Chemokine Receptor 2 (CCR2) belongs to GProtein Coupled Receptor (GPCR) family and expressed in monocytes, immature dendritic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0453a1426975feb05dd7f76ed1c93362
https://doi.org/10.5012/bkcs.2012.33.2.717
https://doi.org/10.5012/bkcs.2012.33.2.717
Autor:
Jee Woong Lim, Jung-Ok Lee, Seung-Woo Lee, Youna Oh, Yongho Na, Gildon Choi, Woo-Kyu Park, Jongmin Kang, Jong Hoon Kim, Heeyeong Cho, Min-Ho Oak
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:2099-2102
Novel 3-aminopyrrolidine derivatives were synthesized and evaluated for their antagonistic activity against human chemokine receptor 2. Structure–activity studies on 3-aminopyrrolidine incorporating heteroatomic carbocycle moieties led to piperidin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d26cd31fedf8fb6d17adabb8724be6b
https://doi.org/10.1016/j.bmcl.2010.02.072
https://doi.org/10.1016/j.bmcl.2010.02.072