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pro vyhledávání: '"Jee E. Rim"'
Summary statistics such as the mean and variance are easily maintained for large, distributed data streams, but order statistics (i.e., sample quantiles) can only be approximately summarized. There is extensive literature on maintaining quantile sket
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4125466c7adf157d8e07dd4891bbd683
Publikováno v:
Biomechanics and Modeling in Mechanobiology. 13:1277-1288
Compact cylindrical and spherical invaginations are common structural motifs found in cellular and developmental biology. To understand the basic physical mechanisms that produce and maintain such structures, we present here a simple model of vesicle
Publikováno v:
Journal of the Mechanical Behavior of Biomedical Materials. 4:190-211
Nacre, the iridescent material found in Abalone shells, exhibits remarkable strength and toughness despite its composition of over 95% brittle ceramic. Its hierarchical structure over multiple length scales gives rise to its increase in toughness des
Publikováno v:
Progress in Materials Science. 54:1059-1100
In contrast to synthetic materials, evolutionary developments in biology have resulted in materials with remarkable structural properties, made out of relatively weak constituents, arranged in complex hierarchical patterns. For instance, nacre from s
Publikováno v:
Journal of Membrane Science. 293:174-182
The stratum corneum is the outermost layer of the skin, which acts as a barrier membrane against the penetration of molecules into and out of the body. It has a biphasic structure consisting of keratinized cells – the corneocytes – that are embed
Publikováno v:
Annals of Biomedical Engineering. 33:1422-1438
The finite element method is employed to simulate two-dimensional (axisymmetric) drug diffusion from a finite drug reservoir into the skin. The numerical formulation is based on a general mathematical model for multicomponent nonlinear diffusion that
Publikováno v:
Rim, Jee E.; Pinsky, Peter M.; & Osdol, William W.(2009). Multiscale Modeling Framework of Transdermal Drug Delivery. Annals of Biomedical Engineering: The Journal of the Biomedical Engineering Society, 37(6), pp 1217-1229. doi: 10.1007/s10439-009-9678-1. Retrieved from: http://www.escholarship.org/uc/item/58p2g44n
This study addresses the modeling of transdermal diffusion of drugs to better understand the permeation of molecules through the skin, especially the stratum corneum, which forms the main permeation barrier to percutaneous permeation. In order to ens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1674e5d6cab82a5503989d1587e532e6
http://www.escholarship.org/uc/item/58p2g44n
http://www.escholarship.org/uc/item/58p2g44n
We report nanofabrication of protein dot and line patterns using a nanofountain atomic force microscopy probe (NFP). Biomolecules are continuously fed in solution through an integrated microfluidic system, and deposited directly onto a substrate. Dep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffd40bd121f2f866e28717161190153e
https://europepmc.org/articles/PMC2575438/
https://europepmc.org/articles/PMC2575438/
Publikováno v:
Journal of biomechanics. 41(4)
The stratum corneum is the outermost layer of the skin, which acts as a barrier membrane against the penetration of molecules into and out of the body. It has a biphasic structure consisting of keratinized cells (corneocytes) that are embedded in a l