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Despite the positive effects of mild hypothermic conditions on monoclonal antibody (mAb) productivity (qmAb) during mammalian cell culture, the impact of reduced culture temperature on mAb Fc-glycosylation and the mechanism behind changes in the glyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1032::da747dc535f4df2e0d542cea7a802de3
http://hdl.handle.net/10044/1/42617
http://hdl.handle.net/10044/1/42617
Autor:
Sou SN; Department of Life Sciences, Imperial College London, London, United Kingdom.; Centre for Synthetic Biology and Innovation, Imperial College London, London, United Kingdom.; Department of Chemical Engineering, Centre for Process Systems Engineering, Imperial College London, London SW7 2AZ, United Kingdom., Jedrzejewski PM; Department of Chemical Engineering, Centre for Process Systems Engineering, Imperial College London, London SW7 2AZ, United Kingdom., Lee K; Cell Culture and Fermentation Sciences, MedImmune, Granta Park, Cambridge, United Kingdom., Sellick C; Cell Culture and Fermentation Sciences, MedImmune, Granta Park, Cambridge, United Kingdom., Polizzi KM; Department of Life Sciences, Imperial College London, London, United Kingdom.; Centre for Synthetic Biology and Innovation, Imperial College London, London, United Kingdom., Kontoravdi C; Department of Chemical Engineering, Centre for Process Systems Engineering, Imperial College London, London SW7 2AZ, United Kingdom.
Publikováno v:
Biotechnology and bioengineering [Biotechnol Bioeng] 2017 Jul; Vol. 114 (7), pp. 1570-1582. Date of Electronic Publication: 2017 Mar 10.
Autor:
Jedrzejewski PM; Centre for Process Systems Engineering, Department of Chemical Engineering, Imperial College London, London SW7 2AZ, UK. philip.jedrzejewski07@imperial.ac.uk., del Val IJ; Centre for Process Systems Engineering, Department of Chemical Engineering, Imperial College London, London SW7 2AZ, UK. ioscani.jimenez-del-val06@imperial.ac.uk., Constantinou A; Department of Life Sciences, Imperial College London, London SW7 2AZ, UK. a.constantinou@imperial.ac.uk., Dell A; Department of Life Sciences, Imperial College London, London SW7 2AZ, UK. a.dell@imperial.ac.uk., Haslam SM; Department of Life Sciences, Imperial College London, London SW7 2AZ, UK. s.haslam@imperial.ac.uk., Polizzi KM; Department of Life Sciences, Imperial College London, London SW7 2AZ, UK. k.polizzi@imperial.ac.uk., Kontoravdi C; Centre for Process Systems Engineering, Department of Chemical Engineering, Imperial College London, London SW7 2AZ, UK. cleo.kontoravdi@imperial.ac.uk.
Publikováno v:
International journal of molecular sciences [Int J Mol Sci] 2014 Mar 14; Vol. 15 (3), pp. 4492-522. Date of Electronic Publication: 2014 Mar 14.