Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Jedida Mwacharo"'
Autor:
Jedida Mwacharo, Matt Berriman, Jean Langhorne, Francis M. Ndungu, Kevin Marsh, Jennifer Musyoki, John W.G. Addy, John Joseph Valletta, Joyce Mwongeli Ngoi, Philip Bejon, Yaw Bediako, Mario Recker, Joshua Wambua, Adam J. Reid, Chris I. Newbold, Khadija Said Mohammed, Edward Otieno
Publikováno v:
Wellcome Open Research, Vol 6 (2022)
After decades of research, our understanding of when and why individuals infected with Plasmodium falciparum develop clinical malaria is still limited. Correlates of immune protection are often sought through prospective cohort studies, where measure
Externí odkaz:
https://doaj.org/article/63369b7637934cea969bd98baf984384
Autor:
John Joseph Valetta, Jedida Mwacharo, Matthew Berriman, Jean Langhorne, Francis M. Ndungu, Kevin Marsh, Jennifer Musyoki, John W.G. Addy, Joyce Mwongeli Ngoi, Yaw Bediako, Philip Bejon, Mario Recker, Joshua Wambua, Adam J. Reid, Edward Otieno, Khadija Said Mohammed
Publikováno v:
Wellcome Open Research, Vol 6 (2022)
Background: Studies of long-term malaria cohorts have provided essential insights into how Plasmodium falciparum interacts with humans, and influences the development of antimalarial immunity. Immunity to malaria is acquired gradually after multiple
Externí odkaz:
https://doaj.org/article/3c6460d553e64a7b9d05aef883a961a6
Autor:
John Mwita Morobe, Brigitte Pool, Lina Marie, Dwayne Didon, Arnold W. Lambisia, Timothy Makori, Khadija Said Mohammed, Zaydah R. de Laurent, Leonard Ndwiga, Maureen W. Mburu, Edidah Moraa, Nickson Murunga, Jennifer Musyoki, Jedida Mwacharo, Lydia Nyamako, Debra Riako, Pariken Ephnatus, Faith Gambo, Josephine Naimani, Joyce Namulondo, Susan Zimba Tembo, Edwin Ogendi, Thierno Balde, Fred Athanasius Dratibi, Ali Ahmed Yahaya, Nicksy Gumede, Rachel A. Achilla, Peter K. Borus, Dorcas W. Wanjohi, Sofonias K. Tessema, Joseph Mwangangi, Philip Bejon, David J. Nokes, Lynette Isabella Ochola-Oyier, George Githinji, Leon Biscornet, Charles N. Agoti
Publikováno v:
Viruses, Vol 14, Iss 6, p 1318 (2022)
Seychelles, an archipelago of 155 islands in the Indian Ocean, had confirmed 24,788 cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by the 31st of December 2021. The first SARS-CoV-2 cases in Seychelles were reported on the 14th
Externí odkaz:
https://doaj.org/article/b464c8f6c02b4f0a9f271beed2f1d5be
Autor:
Henry J. Sutton, Racheal Aye, Azza H. Idris, Rachel Vistein, Eunice Nduati, Oscar Kai, Jedida Mwacharo, Xi Li, Xin Gao, T. Daniel Andrews, Marios Koutsakos, Thi H.O. Nguyen, Maxim Nekrasov, Peter Milburn, Auda Eltahla, Andrea A. Berry, Natasha KC, Sumana Chakravarty, B. Kim Lee Sim, Adam K. Wheatley, Stephen J. Kent, Stephen L. Hoffman, Kirsten E. Lyke, Philip Bejon, Fabio Luciani, Katherine Kedzierska, Robert A. Seder, Francis M. Ndungu, Ian A. Cockburn
Publikováno v:
Cell Reports, Vol 34, Iss 6, Pp 108684- (2021)
Summary: The diversity of circulating human B cells is unknown. We use single-cell RNA sequencing (RNA-seq) to examine the diversity of both antigen-specific and total B cells in healthy subjects and malaria-exposed individuals. This reveals two B ce
Externí odkaz:
https://doaj.org/article/89e5cacd4e494e17b4311ab2314f1aaf
Autor:
Francis M. Ndungu, Jedida Mwacharo, Juliana Wambua, Patricia Njuguna, Kevin Marsh, Chris Drakeley, Philip Bejon
Publikováno v:
Wellcome Open Research, Vol 4 (2019)
Background: RTS,S/AS01 E, the most advanced malaria vaccine confers partial immunity. The vaccine-induced pre-erythrocytic immunity reduces exposure to blood-stage parasites, delaying acquisition of antibodies to blood-stage antigens. However, the du
Externí odkaz:
https://doaj.org/article/44055e6b44734049b940e671065276c3
Autor:
Frances Ibison, Ally Olotu, Daniel M Muema, Jedida Mwacharo, Eric Ohuma, Domtila Kimani, Kevin Marsh, Philip Bejon, Francis M Ndungu
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e52939 (2012)
BACKGROUND:Although antibodies are critical for immunity to malaria, their functional attributes that determine protection remain unclear. We tested for associations between antibody avidities to Plasmodium falciparum (Pf) antigens and age, asymptoma
Externí odkaz:
https://doaj.org/article/3c67613d954b4caa827ac25978bbf84b
Autor:
Jedida Mwacharo, Ian A. Cockburn, Juliana Wambua, Henry J. Sutton, Francis M. Ndungu, Philip Bejon, Racheal Aye, Eunice Nduati, Jennifer N. Musyoki, Oscar Kai, Edward Otieno
Publikováno v:
European journal of immunology
Atypical memory B cells (aMBCs) are found in elevated numbers in individuals exposed to malaria. A key question is whether malaria induces aMBCs as a result of exposure to Ag, or non-Ag-specific mechanisms. We identified Plasmodium and bystander teta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a094ad9bede4b284f7e4685d8b63c8c4
https://doi.org/10.1002/eji.201948473
https://doi.org/10.1002/eji.201948473
Autor:
Thi H. O. Nguyen, B. Kim Lee Sim, Rachel Vistein, Francis M. Ndungu, Adam K. Wheatley, Eunice Nduati, Fabio Luciani, Stephen L. Hoffman, Stephen J. Kent, Peter J. Milburn, Philip Bejon, Xin Gao, Maxim Nekrasov, Henry J. Sutton, Sumana Chakravarty, T. Daniel Andrews, Xi Li, Oscar Kai, Jedida Mwacharo, Kirsten E. Lyke, Robert A. Seder, Azza H. Idris, Andrea A. Berry, Natasha Kc, Racheal Aye, Marios Koutsakos, Ian A. Cockburn, Katherine Kedzierska, Auda Ethala
The full diversity of the circulating human B cell compartment is unknown. Flow cytometry analysis suggests that in addition to naïve and memory B cells, there exists a population of CD11c+, CD27− CD21− “atypical” B cells, that are associate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a092d07df1df54c34e83d346b02277a
https://doi.org/10.1101/2020.05.28.120808
https://doi.org/10.1101/2020.05.28.120808
Autor:
Sarah H. Atkinson, Cleopatra K Mugyenyi, Angela Nalwoga, John Muthii Muriuki, Philip Bejon, Thomas N. Williams, Jedida Mwacharo, Caroline K. Bundi, Joseph Gikunju, James G. Beeson, Francis M. Ndungu, Alexander J. Mentzer, Reagan M. Mogire, Alison M. Elliott, Emily L. Webb, Lawrence Lubyayi, Herbert Opi
Publikováno v:
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Background Iron deficiency (ID) and malaria are common causes of ill-health and disability among children living in sub-Saharan Africa. Although iron is critical for the acquisition of humoral immunity, little is known about the effects of ID on anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e022755eccecffc28331841538b77bb
https://ora.ox.ac.uk/objects/uuid:8162e4f4-968b-4f12-8c99-70cf9b9fb884
https://ora.ox.ac.uk/objects/uuid:8162e4f4-968b-4f12-8c99-70cf9b9fb884
Autor:
Irene Omedo, Gregory Fegan, Thomas N. Williams, R Morter, George Nyangweso, Juliana Wambua, Jedida Mwacharo, Philip Bejon, Christopher Nyundo, Domtila Kimani, Polycarp Mogeni, Melissa C. Kapulu, Joyce M. Ngoi
Publikováno v:
The Journal of Infectious Diseases
Background Malaria control strategies need to respond to geographical hotspots of transmission. Detection of hotspots depends on the sensitivity of the diagnostic tool used. Methods We conducted cross-sectional surveys in 3 sites within Kilifi County
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3097cf9b1c528313523adac9c1266ff6
https://doi.org/10.1093/infdis/jix321
https://doi.org/10.1093/infdis/jix321