Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Jedd Hillegass"'
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 137
In silico models are often built solely on publicly available data which may mean that they are less predictive for proprietary chemical space. Data sharing initiatives can improve the performance of such models, but organisations are often unable to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::475a7292e4817cc2e56798489bbbbb61
https://pubmed.ncbi.nlm.nih.gov/36400282
https://pubmed.ncbi.nlm.nih.gov/36400282
Autor:
Jessica C. Graham, Alejandra Trejo-Martin, Martyn L. Chilton, Jakub Kostal, Joel Bercu, Gregory L. Beutner, Uma S. Bruen, David G. Dolan, Stephen Gomez, Jedd Hillegass, John Nicolette, Matthew Schmitz
Publikováno v:
Chemical research in toxicology. 35(6)
Peptide couplers (also known as amide bond-forming reagents or coupling reagents) are broadly used in organic chemical syntheses, especially in the pharmaceutical industry. Yet, occupational health hazards associated with this chemical class are larg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83ea18af40f3631f3592327aa4d47482
https://pubmed.ncbi.nlm.nih.gov/35532537
https://pubmed.ncbi.nlm.nih.gov/35532537
Autor:
Ernst Ahlberg, Tatyana Y. Doktorova, Alexis Parenty, Thomas Exner, David Woolley, Angela White, Alessandro Brigo, Scott Miller, Jason Magby, Rahul Parakhia, David W. Roberts, Thibaud Weiler, Raymond R. Tice, David Faulkner, Eckart Krupp, Candice Y. Johnson, Amanda Giddings, Ana Theresa Paulino, Jessica Whritenour, Véronique Gervais, Barry Hardy, Ian M. Fearon, Louise Neilson, Alexandre Paulino, Sarah Campbell, Shayne C. Gad, Sol Bobst, Reinhard Stidl, Liat Lomnitski, Anna Vuorinen, Lawrence Milchak, Craig Zwickl, Harald Schlecker, Wolfgang Muster, David T. Szabo, Lisa Beilke, Mark T. D. Cronin, Daniel Urbisch, Glenn J. Myatt, Joel P. Bercu, Robert A. Jolly, Brian A. Wall, Markus Fehr, Romualdo Benigni, Lennart T. Anger, Ian Crooks, Patricia Parris, Kevin P. Cross, Joerg Wichard, David Bower, Diana Suarez-Rodrigez, Jedd Hillegass, Catrin Hasselgren, Susanne Glowienke, Jordi Mestres
Publikováno v:
Regul Toxicol Pharmacol
The assessment of skin sensitization has evolved over the past few years to include in vitro assessments of key events along the adverse outcome pathway and opportunistically capitalize on the strengths of in silico methods to support a weight of evi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fc9080fa2ddd4532dad416d216a1d7b
http://hdl.handle.net/10230/45587
http://hdl.handle.net/10230/45587
Autor:
Kyle P. Glover, Yumi Akahori, Michelle O. Kenyon, David Jones, Angela White, Patricia Ruiz, Dave Bower, Mark Powley, Janet Moser, Naomi L. Kruhlak, Diana Suarez-Rodriguez, Laura Custer, Chia Wen Hsu, Masamitsu Honma, Joel P. Bercu, Steve Gutsell, Krista L. Dobo, Bernhard Majer, Andrew Teasdale, Lidiya Stavitskaya, Aynur O. Aptula, Barry Hardy, Candice Y. Johnson, Scott S. Auerbach, Nichola Gellatly, Rositsa Serafimova, David Allen, Samantha E. Gad-McDonald, Alessandro Brigo, Lennart T. Anger, Kevin P. Cross, Pete Watts, Louise Neilson, Wendy Simpson, Jedd Hillegass, Véronique Gervais, Penny Leavitt, Jui-Hua Hsieh, Kristine L. Witt, Reinhard Stidl, Magdalena Dettwiler, K. Hughes, Romualdo Benigni, Lisa Beilke, Marlene T. Kim, Scott A. Masten, Adam Woolley, Phillip Bellion, Kevin A. Ford, David T. Szabo, Alexander Amberg, Anna Vuorinen, Brian A. Wall, Mark T. D. Cronin, Marie C. Fortin, Zoryana Cammerer, Benoît Schilter, Glenn J. Myatt, Klaus Kümmerer, Ernst Ahlberg, Grace Patlewicz, M. Vijayaraj Reddy, Craig Zwickl, Donald P. Quigley, David Woolley, Tudor I. Oprea, Jacky Van Gompel, Ewan D. Booth, Alexandre Paulino, Wolfgang Muster, Sunil Kulkarni, Alejandra Trejo-Martin, Moiz Mumtaz, Andrea Richarz, Joerg Wichard, James Harvey, Susanne Glowienke, Elena Lo Piparo, Natalie Burden, Catrin Hasselgren, Jean Pierre Valentin, Robert A. Jolly, Scott Miller, Ray Kemper
Publikováno v:
Myatt, G J, Ahlberg, E, Akahori, Y, Allen, D, Amberg, A, Anger, L T, Aptula, A, Auerbach, S, Beilke, L, Bellion, P, Benigni, R, Bercu, J, Booth, E D, Bower, D, Brigo, A, Burden, N, Cammerer, Z, Cronin, M T D, Cross, K P, Custer, L, Dettwiler, M, Dobo, K, Ford, K A, Fortin, M C, Gad-McDonald, S E, Gellatly, N, Gervais, V, Glover, K P, Glowienke, S, Van Gompel, J, Gutsell, S, Hardy, B, Harvey, J S, Hillegass, J, Honma, M, Hsieh, J H, Hsu, C W, Hughes, K, Johnson, C, Jolly, R, Jones, D, Kemper, R, Kenyon, M O, Kim, M T, Kruhlak, N L, Kulkarni, S A, Kümmerer, K, Leavitt, P, Majer, B, Masten, S, Miller, S, Moser, J, Mumtaz, M, Muster, W, Neilson, L, Oprea, T I, Patlewicz, G, Paulino, A, Lo Piparo, E, Powley, M, Quigley, D P, Reddy, M V, Richarz, A N, Ruiz, P, Schilter, B, Serafimova, R, Simpson, W, Stavitskaya, L, Stidl, R, Suarez-Rodriguez, D, Szabo, D T, Teasdale, A, Trejo-Martin, A, Valentin, J P, Vuorinen, A, Wall, B A, Watts, P, White, A T, Wichard, J, Witt, K L, Woolley, A, Woolley, D, Zwickl, C & Hasselgren, C 2018, ' In silico toxicology protocols ' Regulatory toxicology and pharmacology : RTP, vol 96, pp. 1-17 . DOI: 10.1016/j.yrtph.2018.04.014
Myatt, G J, Ahlberg, E, Akahori, Y, Allen, D, Amberg, A, Anger, L T, Aptula, A, Auerbach, S, Beilke, L, Bellion, P, Benigni, R, Bercu, J, Booth, E D, Bower, D, Brigo, A, Burden, N, Cammerer, Z, Cronin, M T D, Cross, K P, Custer, L, Dettwiler, M, Dobo, K, Ford, K A, Fortin, M C, Gad-McDonald, S E, Gellatly, N, Gervais, V, Glover, K P, Glowienke, S, Van Gompel, J, Gutsell, S, Hardy, B, Harvey, J S, Hillegass, J, Honma, M, Hsieh, J H, Hsu, C W, Hughes, K, Johnson, C, Jolly, R, Jones, D, Kemper, R, Kenyon, M O, Kim, M T, Kruhlak, N L, Kulkarni, S A, Kümmerer, K, Leavitt, P, Majer, B, Masten, S, Miller, S, Moser, J, Mumtaz, M, Muster, W, Neilson, L, Oprea, T I, Patlewicz, G, Paulino, A, Lo Piparo, E, Powley, M, Quigley, D P, Reddy, M V, Richarz, A N, Ruiz, P, Schilter, B, Serafimova, R, Simpson, W, Stavitskaya, L, Stidl, R, Suarez-Rodriguez, D, Szabo, D T, Teasdale, A, Trejo-Martin, A, Valentin, J P, Vuorinen, A, Wall, B A, Watts, P, White, A T, Wichard, J, Witt, K L, Woolley, A, Woolley, D, Zwickl, C & Hasselgren, C 2018, ' In silico toxicology protocols ', Regulatory toxicology and pharmacology : RTP, vol. 96, pp. 1-17 . https://doi.org/10.1016/j.yrtph.2018.04.014
Myatt, G J, Ahlberg, E, Akahori, Y, Allen, D, Amberg, A, Anger, L T, Aptula, A, Auerbach, S, Beilke, L, Bellion, P, Benigni, R, Bercu, J, Booth, E D, Bower, D, Brigo, A, Burden, N, Cammerer, Z, Cronin, M T D, Cross, K P, Custer, L, Dettwiler, M, Dobo, K, Ford, K A, Fortin, M C, Gad-McDonald, S E, Gellatly, N, Gervais, V, Glover, K P, Glowienke, S, Van Gompel, J, Gutsell, S, Hardy, B, Harvey, J S, Hillegass, J, Honma, M, Hsieh, J H, Hsu, C W, Hughes, K, Johnson, C, Jolly, R, Jones, D, Kemper, R, Kenyon, M O, Kim, M T, Kruhlak, N L, Kulkarni, S A, Kümmerer, K, Leavitt, P, Majer, B, Masten, S, Miller, S, Moser, J, Mumtaz, M, Muster, W, Neilson, L, Oprea, T I, Patlewicz, G, Paulino, A, Lo Piparo, E, Powley, M, Quigley, D P, Reddy, M V, Richarz, A N, Ruiz, P, Schilter, B, Serafimova, R, Simpson, W, Stavitskaya, L, Stidl, R, Suarez-Rodriguez, D, Szabo, D T, Teasdale, A, Trejo-Martin, A, Valentin, J P, Vuorinen, A, Wall, B A, Watts, P, White, A T, Wichard, J, Witt, K L, Woolley, A, Woolley, D, Zwickl, C & Hasselgren, C 2018, ' In silico toxicology protocols ', Regulatory toxicology and pharmacology : RTP, vol. 96, pp. 1-17 . https://doi.org/10.1016/j.yrtph.2018.04.014
The present publication surveys several applications of in silico (i.e., computational) toxicology approaches across different industries and institutions. It highlights the need to develop standardized protocols when conducting toxicity-related pred
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e30474fda768266769a029d23592f910
https://doi.org/10.1016/j.yrtph.2018.04.014
https://doi.org/10.1016/j.yrtph.2018.04.014
Autor:
Rachael E. Tennant, Devin O'Brien, Thomas Steger-Hartmann, Jonathan D. Vessey, Steven J. Canipa, Ann De Smedt, Rachel Hemingway, Angela White, Martyn L. Chilton, Rahul Parakhia, Sylvain Etter, Jeffrey Plante, Jedd Hillegass, Janet Gould, Alun Myden, Paul Sterchele, Donna S. Macmillan, B. Smith
Publikováno v:
Journal of Applied Toxicology. 37:985-995
Dermal contact with chemicals may lead to an inflammatory reaction known as allergic contact dermatitis. Consequently, it is important to assess new and existing chemicals for their skin sensitizing potential and to mitigate exposure accordingly. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2817357adcea70dfa0e1443634f86d91
https://doi.org/10.1002/jat.3448
https://doi.org/10.1002/jat.3448
Publikováno v:
Regulatory Toxicology and Pharmacology. 119:104816
Acute oral toxicity (AOT) information is utilized to categorize compounds according to the severity of their hazard and used to inform risk assessments for human health and the environment. Given the wealth of historical AOT information and technolog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ab99b1474a530982e8f46b62e102eb1
https://doi.org/10.1016/j.yrtph.2020.104816
https://doi.org/10.1016/j.yrtph.2020.104816
Publikováno v:
Regulatory Toxicology and Pharmacology
In order to develop new and effective medicines, pharmaceutical companies must be modality agnostic. As science reveals an enhanced understanding of biological processes, new therapeutic modalities are becoming important in developing breakthrough th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad41e8fdd7129e5dd3a1800fb1e2aee2
https://doi.org/10.1016/j.yrtph.2020.104813
https://doi.org/10.1016/j.yrtph.2020.104813
Autor:
Hui Wei, Neil Mathias, Jessica C. Graham, Aaron P. Yamniuk, Bonnie Wang, Irvith M. Carvajal, Julien Susan D, Janet Gould, Helen G. Haggerty, Michael J. Graziano, Jedd Hillegass, Alex Kozhich, Todd Davidson
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 100
Protein therapeutics represent a rapidly growing proportion of new medicines being developed by the pharmaceutical industry. As with any new drug, an Occupational Exposure Limit (OEL) should be developed to ensure worker safety. Part of the OEL deter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::864a3503fe07b20b7d2f584e1c2356c3
https://pubmed.ncbi.nlm.nih.gov/30291877
https://pubmed.ncbi.nlm.nih.gov/30291877
Autor:
Donna S. Macmillan, B. Smith, Thomas Steger-Hartmann, Angela White, Rahul Parakhia, Milica Glogovac, Martyn L. Chilton, Paul Sterchele, Anna Vuorinen, Devin O'Brien, Susanne Glowienke, Sylvain Etter, Phillip Bellion, Jedd Hillegass, Ann De Smedt
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 95
A previously published fragmentation method for making reliable negative in silico predictions has been applied to the problem of predicting skin sensitisation in humans, making use of a dataset of over 2750 chemicals with publicly available skin sen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d240d77c8aa2a9ba6e0960d9a5a9632
https://pubmed.ncbi.nlm.nih.gov/29580972
https://pubmed.ncbi.nlm.nih.gov/29580972
Autor:
Markus Frericks, Franck Atienzar, Nichola Gellatly, Candice Y. Johnson, Lisa Beilke, Alessandro Brigo, Laura Custer, Brian A. Wall, Dave Bower, Penny Leavitt, Angela White, Helga Gerets, Ray Kemper, Krista L. Dobo, David Jones, Naomi L. Kruhlak, Ian Crooks, Tara S. Barton-Maclaren, Craig Zwickl, Mark T. D. Cronin, Kevin P. Cross, Michelle O. Kenyon, Jui-Hua Hsieh, Véronique Gervais, Anna Vuorinen, Andrea-Nicole Richarz, David Faulkner, Zoryana Cammerer, Ronald D. Snyder, Jedd Hillegass, Kristine L. Witt, James Harvey, Alexandre Paulino, Glenn J. Myatt, Phillip Bellion, Romualdo Benigni, Marie C. Fortin, Alexander Amberg, Robert A. Jolly, Ernst Ahlberg, Lidiya Stavitskaya, M. Vijayaray Reddy, Chia-Wen Hsu, Mark Powley, Tatyana Y. Doktorova, Scott Miller, Chandrika Moudgal, Masamitsu Honma, Benoît Schilter, Donald P. Quigley, David Woolley, Raymond R. Tice, Samantha E. Gad-McDonald, Pete Watts, Joerg Wichard, Reinhard Stidl, Joel P. Bercu, Andrew Teasdale, Wolfgang Muster, Catrin Hasselgren, Susanne Glowienke, Elena Lo Piparo, Yumi Akahori, Adam Woolley, Klaus Kümmerer, David T. Szabo, Jacky Van Gompel, Sunil Kulkarni, Alejandra Trejo-Martin, Lennart T. Anger, Scott A. Masten, Kevin A. Ford, Scott S. Auerbach, Ewan D. Booth
Publikováno v:
Regul Toxicol Pharmacol
Hasselgren, C, Ahlberg, E, Akahori, Y, Amberg, A, Anger, L T, Atienzar, F, Auerbach, S, Beilke, L, Bellion, P, Benigni, R, Bercu, J, Booth, E D, Bower, D, Brigo, A, Cammerer, Z, Cronin, M T D, Crooks, I, Cross, K P, Custer, L, Dobo, K, Doktorova, T, Faulkner, D, Ford, K A, Fortin, M C, Frericks, M, Gad-McDonald, S E, Gellatly, N, Gerets, H, Gervais, V, Glowienke, S, Van Gompel, J, Harvey, J S, Hillegass, J, Honma, M, Hsieh, J H, Hsu, C W, Barton-Maclaren, T S, Johnson, C, Jolly, R, Jones, D, Kemper, R, Kenyon, M O, Kruhlak, N L, Kulkarni, S A, Kümmerer, K, Leavitt, P, Masten, S, Miller, S, Moudgal, C, Muster, W, Paulino, A, Lo Piparo, E, Powley, M, Quigley, D P, Reddy, M V, Richarz, A N, Schilter, B, Snyder, R D, Stavitskaya, L, Stidl, R, Szabo, D T, Teasdale, A, Tice, R R, Trejo-Martin, A, Vuorinen, A, Wall, B A, Watts, P, White, A T, Wichard, J, Witt, K L, Woolley, A, Woolley, D, Zwickl, C & Myatt, G J 2019, ' Genetic toxicology in silico protocol ', Regulatory Toxicology and Pharmacology, vol. 107, no. 104403, 104403 . https://doi.org/10.1016/j.yrtph.2019.104403
Hasselgren, C, Ahlberg, E, Akahori, Y, Amberg, A, Anger, L T, Atienzar, F, Auerbach, S, Beilke, L, Bellion, P, Benigni, R, Bercu, J, Booth, E D, Bower, D, Brigo, A, Cammerer, Z, Cronin, M T D, Crooks, I, Cross, K P, Custer, L, Dobo, K, Doktorova, T, Faulkner, D, Ford, K A, Fortin, M C, Frericks, M, Gad-McDonald, S E, Gellatly, N, Gerets, H, Gervais, V, Glowienke, S, Van Gompel, J, Harvey, J S, Hillegass, J, Honma, M, Hsieh, J H, Hsu, C W, Barton-Maclaren, T S, Johnson, C, Jolly, R, Jones, D, Kemper, R, Kenyon, M O, Kruhlak, N L, Kulkarni, S A, Kümmerer, K, Leavitt, P, Masten, S, Miller, S, Moudgal, C, Muster, W, Paulino, A, Lo Piparo, E, Powley, M, Quigley, D P, Reddy, M V, Richarz, A N, Schilter, B, Snyder, R D, Stavitskaya, L, Stidl, R, Szabo, D T, Teasdale, A, Tice, R R, Trejo-Martin, A, Vuorinen, A, Wall, B A, Watts, P, White, A T, Wichard, J, Witt, K L, Woolley, A, Woolley, D, Zwickl, C & Myatt, G J 2019, ' Genetic toxicology in silico protocol ', Regulatory Toxicology and Pharmacology, vol. 107, no. 104403, 104403 . https://doi.org/10.1016/j.yrtph.2019.104403
In silico toxicology (IST) approaches to rapidly assess chemical hazard, and usage of such methods is increasing in all applications but especially for regulatory submissions, such as for assessing chemicals under REACH as well as the ICH M7 guidelin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79c7543ee11579b9576d130b0cc8e19f
https://doi.org/10.1016/j.yrtph.2019.104403
https://doi.org/10.1016/j.yrtph.2019.104403