Inhibition of NRF2 signaling overcomes acquired resistance to arsenic trioxide in FLT3-mutated Acute Myeloid Leukemia.

Autor: Jebanesan DZP; Department of Hematology, Christian Medical College Vellore-Ranipet Campus, Tamil Nadu, Vellore, 632517, India.; Manipal Academy of Higher Education, Manipal, India., Illangeswaran RSS; Department of Hematology, Christian Medical College Vellore-Ranipet Campus, Tamil Nadu, Vellore, 632517, India., Rajamani BM; Department of Hematology, Christian Medical College Vellore-Ranipet Campus, Tamil Nadu, Vellore, 632517, India., Vidhyadharan RT; Department of Hematology, Christian Medical College Vellore-Ranipet Campus, Tamil Nadu, Vellore, 632517, India., Das S; Department of Hematology, Christian Medical College Vellore-Ranipet Campus, Tamil Nadu, Vellore, 632517, India., Bijukumar NK; Department of Hematology, Christian Medical College Vellore-Ranipet Campus, Tamil Nadu, Vellore, 632517, India., Balakrishnan B; Department of Hematology, Christian Medical College Vellore-Ranipet Campus, Tamil Nadu, Vellore, 632517, India.; Department of Integrative Biology, School of BioSciences and Technology, Vellore Institute of Technology, Vellore, India., Mathews V; Department of Hematology, Christian Medical College Vellore-Ranipet Campus, Tamil Nadu, Vellore, 632517, India., Velayudhan SR; Department of Hematology, Christian Medical College Vellore-Ranipet Campus, Tamil Nadu, Vellore, 632517, India.; Adjunct Scientist, Centre for Stem Cell Research, A Unit of InStem Bengaluru, CMC Campus, Vellore, India., Balasubramanian P; Department of Hematology, Christian Medical College Vellore-Ranipet Campus, Tamil Nadu, Vellore, 632517, India. bpoonkuzhali@cmcvellore.ac.in.

Publikováno v: Annals of hematology [Ann Hematol] 2024 Jun; Vol. 103 (6), pp. 1919-1929. Date of Electronic Publication: 2024 Apr 17.

Modulating retinoid-X-receptor alpha (RXRA) expression sensitizes chronic myeloid leukemia cells to imatinib in vitro and reduces disease burden in vivo .

Autor: Rajamani BM; Department of Haematology, Christian Medical College, Vellore, India.; Department of Biotechnology, Thiruvalluvar University, Vellore, India., Illangeswaran RSS; Department of Haematology, Christian Medical College, Vellore, India.; Department of Biotechnology, Thiruvalluvar University, Vellore, India., Benjamin ESB; Department of Haematology, Christian Medical College, Vellore, India.; Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, India., Balakrishnan B; Department of Haematology, Christian Medical College, Vellore, India.; Department of Integrative Biology, School of Bio Sciences and Technology, Vellore Institute of Technology, Vellore, India., Jebanesan DZP; Department of Haematology, Christian Medical College, Vellore, India.; Manipal Academy of Higher Education, Manipal, India., Das S; Department of Haematology, Christian Medical College, Vellore, India.; Department of Biotechnology, Thiruvalluvar University, Vellore, India., Pai AA; Department of Haematology, Christian Medical College, Vellore, India.; Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, India., Vidhyadharan RT; Department of Haematology, Christian Medical College, Vellore, India., Mohan A; Department of Haematology, Christian Medical College, Vellore, India., Karathedath S; Department of Haematology, Christian Medical College, Vellore, India., Abraham A; Department of Haematology, Christian Medical College, Vellore, India., Mathews V; Department of Haematology, Christian Medical College, Vellore, India., Velayudhan SR; Department of Haematology, Christian Medical College, Vellore, India.; Centre for Stem Cell Research (CSCR), A Unit of InStem Bengaluru, Christian Medical College Campus, Vellore, India., Balasubramanian P; Department of Haematology, Christian Medical College, Vellore, India.

Publikováno v: Frontiers in pharmacology [Front Pharmacol] 2023 May 31; Vol. 14, pp. 1187066. Date of Electronic Publication: 2023 May 31 (Print Publication: 2023).