Zobrazeno 1 - 10 of 866 pro vyhledávání: '"Jeay, S."'
1
Akademický článek
Design of Dual EP2/EP4 Antagonists through Scaffold Merging of Selective Inhibitors.
Autor: Corminboeuf O; Drug Discovery, Idorsia Pharmaceuticals Ltd., Hegenheimermattweg 91, 4123, Allschwil, Switzerland., Diethelm S; Drug Discovery, Idorsia Pharmaceuticals Ltd., Hegenheimermattweg 91, 4123, Allschwil, Switzerland., Zumbrunn C; Drug Discovery, Idorsia Pharmaceuticals Ltd., Hegenheimermattweg 91, 4123, Allschwil, Switzerland., Lyothier I; Drug Discovery, Idorsia Pharmaceuticals Ltd., Hegenheimermattweg 91, 4123, Allschwil, Switzerland., Niggli N; Drug Discovery, Idorsia Pharmaceuticals Ltd., Hegenheimermattweg 91, 4123, Allschwil, Switzerland., Gnerre C; Drug Discovery, Idorsia Pharmaceuticals Ltd., Hegenheimermattweg 91, 4123, Allschwil, Switzerland., Jeay S; Drug Discovery, Idorsia Pharmaceuticals Ltd., Hegenheimermattweg 91, 4123, Allschwil, Switzerland., Lehembre F; Drug Discovery, Idorsia Pharmaceuticals Ltd., Hegenheimermattweg 91, 4123, Allschwil, Switzerland., Boss C; Drug Discovery, Idorsia Pharmaceuticals Ltd., Hegenheimermattweg 91, 4123, Allschwil, Switzerland.
Publikováno v: ChemMedChem [ChemMedChem] 2024 Jan 15; Vol. 19 (2), pp. e202300606. Date of Electronic Publication: 2023 Dec 06.
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2
Akademický článek
Pharmacokinetic-pharmacodynamic guided optimisation of dose and schedule of CGM097, an HDM2 inhibitor, in preclinical and clinical studies.
Autor: Bauer S; Department of Medical Oncology, Sarcoma Center, West German Cancer Center, University of Duisburg-Essen, Duisburg-Essen, Germany. sebastian.bauer@uk-essen.de., Demetri GD; Dana-Farber Cancer Institute and Ludwig Center at Harvard Medical School, Boston, MA, USA., Halilovic E; Novartis Institutes for BioMedical Research (NIBR), Cambridge, MA, USA., Dummer R; University Hospital Zurich, Zurich, Switzerland., Meille C; Novartis Institutes for BioMedical Research (NIBR), Basel, Switzerland., Tan DSW; National Cancer Center Singapore, Singapore, Singapore., Guerreiro N; Novartis Institutes for BioMedical Research (NIBR), Basel, Switzerland.; F. Hoffmann-La Roche AG, Basel, Switzerland., Jullion A; Novartis Institutes for BioMedical Research (NIBR), Basel, Switzerland., Ferretti S; Novartis Institutes for BioMedical Research (NIBR), Basel, Switzerland., Jeay S; Novartis Institutes for BioMedical Research (NIBR), Basel, Switzerland.; Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland., Van Bree L; Novartis Institutes for BioMedical Research (NIBR), Basel, Switzerland., Hourcade-Potelleret F; Novartis Institutes for BioMedical Research (NIBR), Basel, Switzerland., Wuerthner JU; Novartis Institutes for BioMedical Research (NIBR), Basel, Switzerland.; ADC Therapeutics, Epalinges, Switzerland., Fabre C; Novartis Institutes for BioMedical Research (NIBR), Basel, Switzerland., Cassier PA; Department of Medical Oncology, Centre Léon Bérard, Lyon, France.
Publikováno v: British journal of cancer [Br J Cancer] 2021 Aug; Vol. 125 (5), pp. 687-698. Date of Electronic Publication: 2021 Jun 17.
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3
Akademický článek
Discovery of the Clinical Candidate MAK683: An EED-Directed, Allosteric, and Selective PRC2 Inhibitor for the Treatment of Advanced Malignancies.
Autor: Huang Y; Novartis Institutes for BioMedical Research, 4218 Jinke Road, Shanghai 201203, China., Sendzik M; Novartis Institutes for BioMedical Research, 5300 Chiron Way, Emeryville, California 94608, United States.; Novartis Institutes for BioMedical Research, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States., Zhang J; Novartis Institutes for BioMedical Research, 4218 Jinke Road, Shanghai 201203, China., Gao Z; Novartis Institutes for BioMedical Research, 4218 Jinke Road, Shanghai 201203, China., Sun Y; Novartis Institutes for BioMedical Research, 4218 Jinke Road, Shanghai 201203, China., Wang L; Novartis Institutes for BioMedical Research, 4218 Jinke Road, Shanghai 201203, China., Gu J; Novartis Institutes for BioMedical Research, 4218 Jinke Road, Shanghai 201203, China., Zhao K; Novartis Institutes for BioMedical Research, 4218 Jinke Road, Shanghai 201203, China., Yu Z; Novartis Institutes for BioMedical Research, 4218 Jinke Road, Shanghai 201203, China., Zhang L; Novartis Institutes for BioMedical Research, 4218 Jinke Road, Shanghai 201203, China., Zhang Q; Novartis Institutes for BioMedical Research, 4218 Jinke Road, Shanghai 201203, China., Blanz J; Novartis Institutes for BioMedical Research, Novartis Campus, 4056 Basel, Switzerland., Chen Z; Novartis Institutes for BioMedical Research, 4218 Jinke Road, Shanghai 201203, China., Dubost V; Novartis Institutes for BioMedical Research, Novartis Campus, 4056 Basel, Switzerland., Fang D; Novartis Institutes for BioMedical Research, 4218 Jinke Road, Shanghai 201203, China., Feng L; Novartis Institutes for BioMedical Research, 4218 Jinke Road, Shanghai 201203, China., Fu X; Novartis Institutes for BioMedical Research, 4218 Jinke Road, Shanghai 201203, China., Kiffe M; Novartis Institutes for BioMedical Research, Novartis Campus, 4056 Basel, Switzerland., Li L; Novartis Institutes for BioMedical Research, 4218 Jinke Road, Shanghai 201203, China., Luo F; Novartis Institutes for BioMedical Research, 4218 Jinke Road, Shanghai 201203, China., Luo X; Novartis Institutes for BioMedical Research, 4218 Jinke Road, Shanghai 201203, China., Mi Y; Novartis Institutes for BioMedical Research, 4218 Jinke Road, Shanghai 201203, China., Mistry P; Novartis Institutes for BioMedical Research, Novartis Campus, 4056 Basel, Switzerland., Pearson D; Novartis Institutes for BioMedical Research, Novartis Campus, 4056 Basel, Switzerland., Piaia A; Novartis Institutes for BioMedical Research, Novartis Campus, 4056 Basel, Switzerland., Scheufler C; Novartis Institutes for BioMedical Research, Novartis Campus, 4056 Basel, Switzerland., Terranova R; Novartis Institutes for BioMedical Research, Novartis Campus, 4056 Basel, Switzerland., Weiss A; Novartis Institutes for BioMedical Research, Novartis Campus, 4056 Basel, Switzerland., Zeng J; Novartis Institutes for BioMedical Research, 4218 Jinke Road, Shanghai 201203, China., Zhang H; Novartis Institutes for BioMedical Research, 4218 Jinke Road, Shanghai 201203, China., Zhang J; Novartis Institutes for BioMedical Research, 4218 Jinke Road, Shanghai 201203, China., Zhao M; Novartis Institutes for BioMedical Research, 4218 Jinke Road, Shanghai 201203, China., Dillon MP; Novartis Institutes for BioMedical Research, 5300 Chiron Way, Emeryville, California 94608, United States., Jeay S; Novartis Institutes for BioMedical Research, Novartis Campus, 4056 Basel, Switzerland., Qi W; Novartis Institutes for BioMedical Research, 4218 Jinke Road, Shanghai 201203, China., Moggs J; Novartis Institutes for BioMedical Research, Novartis Campus, 4056 Basel, Switzerland., Pissot-Soldermann C; Novartis Institutes for BioMedical Research, Novartis Campus, 4056 Basel, Switzerland., Li E; Novartis Institutes for BioMedical Research, 4218 Jinke Road, Shanghai 201203, China., Atadja P; Novartis Institutes for BioMedical Research, 4218 Jinke Road, Shanghai 201203, China., Lingel A; Novartis Institutes for BioMedical Research, 5300 Chiron Way, Emeryville, California 94608, United States.; Novartis Institutes for BioMedical Research, Novartis Campus, 4056 Basel, Switzerland., Oyang C; Novartis Institutes for BioMedical Research, 4218 Jinke Road, Shanghai 201203, China.
Publikováno v: Journal of medicinal chemistry [J Med Chem] 2022 Apr 14; Vol. 65 (7), pp. 5317-5333. Date of Electronic Publication: 2022 Mar 30.
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4
Akademický článek
Repurposing of c-MET Inhibitor Tivantinib Inhibits Pediatric Neuroblastoma Cellular Growth.
Autor: Chilamakuri, Rameswari1 (AUTHOR), Agarwal, Saurabh1 (AUTHOR) agarwals@stjohns.edu
Publikováno v: Pharmaceuticals (14248247). Oct2024, Vol. 17 Issue 10, p1350. 15p.
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5
Akademický článek
Placental Gene Therapy for Fetal Growth Restriction and Preeclampsia: Preclinical Studies and Prospects for Clinical Application.
Autor: Majumder, Sanjukta1,2 (AUTHOR) majumder@uchc.edu, Moriarty, Kristen Lee1,3 (AUTHOR) kmoriarty@uchc.edu, Lee, Youngmok4 (AUTHOR) yolee@uchc.edu, Crombleholme, Timothy M.1,2,4 (AUTHOR) tcrombleholme@connecticutchildrens.org
Publikováno v: Journal of Clinical Medicine. Sep2024, Vol. 13 Issue 18, p5647. 15p.
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6
Akademický článek
Ubiquitination and deubiquitination in cancer: from mechanisms to novel therapeutic approaches.
Autor: Liu, Fangfang1,2 (AUTHOR), Chen, Jingyu3 (AUTHOR), Li, Kai4 (AUTHOR), Li, Haochen4 (AUTHOR), Zhu, Yiyi4 (AUTHOR), Zhai, Yubo5 (AUTHOR), Lu, Bingbing5 (AUTHOR), Fan, Yanle2 (AUTHOR), Liu, Ziyue5 (AUTHOR), Chen, Xiaojie6 (AUTHOR), Jia, Xuechao7 (AUTHOR) xcjia@hci-cn.org, Dong, Zigang1,2,5 (AUTHOR) dongzg@zzu.edu.cn, Liu, Kangdong1,5 (AUTHOR) kdliu@zzu.edu.cn
Publikováno v: Molecular Cancer. 7/25/2024, Vol. 23 Issue 1, p1-50. 50p.
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7
Akademický článek
Insights into the Interaction Mechanisms of Peptide and Non-Peptide Inhibitors with MDM2 Using Gaussian-Accelerated Molecular Dynamics Simulations and Deep Learning.
Autor: Yang, Wanchun1 (AUTHOR) wangjian_lxy@sdjtu.edu.cn, Wang, Jian1 (AUTHOR), Zhao, Lu1 (AUTHOR), Chen, Jianzhong1 (AUTHOR) yangwch1982@126.com
Publikováno v: Molecules. Jul2024, Vol. 29 Issue 14, p3377. 22p.
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8
Akademický článek
Hypoxia activates autophagy by Akt/FoxO1 pathway in fish cells.
Autor: Kang Chen1 571685020@qq.com, Linlin Shi1 376603966@qq.com, Hong Liu1,2 liuhong59@mail.hzau.edu.cn, Huanling Wang1,2 hbauwhl@hotmail.com
Publikováno v: Aquaculture & Fisheries (2096-1758). Jul2024, Vol. 9 Issue 4, p557-565. 9p.
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