Relative bioavailability of bedaquiline tablets suspended in water: Implications for dosing in children

Autor: Rene Kitshoff, Betsy Smith, Jeannine du Bois, Andreas H. Diacon, Jennifer Norman, Anneke C. Hesseling, Elin M. Svensson, Sharon Nachman, Lubbe Wiesner, Veronique R. de Jager, Anthony J. Garcia-Prats

Publikováno v: British Journal of Clinical Pharmacology. 84:2384-2392

Aims Bedaquiline is an important novel drug for treatment of multidrug-resistant tuberculosis, but no paediatric formulation is yet available. This work aimed to explore the possibility of using the existing tablet formulation in children by evaluati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::88ef61afbf380c18967bd99e721c6f38
https://doi.org/10.1111/bcp.13696

Early phase evaluation of SQ109 alone and in combination with rifampicin in pulmonary TB patients

Autor: Norbert, Heinrich, Rodney, Dawson, Jeannine, du Bois, Kim, Narunsky, Gary, Horwith, Andrew J, Phipps, Carol A, Nacy, Rob E, Aarnoutse, Martin J, Boeree, Stephen H, Gillespie, Amour, Venter, Sonja, Henne, Andrea, Rachow, Patrick P J, Phillips, Michael, Hoelscher, Andreas H, Diacon, Alphonse, Okwera

Publikováno v: Journal of Antimicrobial Chemotherapy, 70, 5, pp. 1558-66
Journal of Antimicrobial Chemotherapy, 70, 1558-66

Objectives SQ109, an asymmetrical diamine, is a novel anti-TB drug candidate. This first study in patients was done to determine safety, tolerability, pharmacokinetics and bacteriological effect of different doses of SQ109 alone and in combination wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93c2bca9dfa86332c36c960317059ca2
https://doi.org/10.1093/jac/dku553

Early Bactericidal Activity of AZD5847 in Patients with Pulmonary Tuberculosis

Autor: John L. Johnson, Charles A. Peloquin, Jennifer Furin, Phalkun Chheng, Amour Venter, Abdullah Alsultan, Andreas H. Diacon, Bonnie Thiel, Jeannine Du Bois, Elana van Brakel, W. Henry Boom, Sara M. Debanne

AZD5847 is an oxazolidinone antibiotic with in vitro activity against Mycobacterium tuberculosis . The objective of this study was to evaluate the antimycobacterial activity, safety, and pharmacokinetics of AZD5847 in patients with pulmonary tubercul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52ae3b8cc0288d4d65d1a4ea2be8d971
https://europepmc.org/articles/PMC5075064/

A Step toward an Optimized Rifampin Dose Completed

Autor: David M. Burger, Patrick P. J. Phillips, Georgette Plemper van Balen, Sunita Rehal, Martin J. Boeree, Dick van Soolingen, Jeannine Du Bois, Jakko van Ingen, Norbert Heinrich, Rodney Dawson, Rob E. Aarnoutse, Amour Venter, Timothy D. McHugh, Cecile Magis-Escurra, Andreas H. Diacon, Kim Narunsky, Michael Hoelscher, Stephen H. Gillespie

Publikováno v: American Journal of Respiratory and Critical Care Medicine, 192, 4, pp. 525-6
Scopus-Elsevier
ResearcherID
American Journal of Respiratory and Critical Care Medicine, 192, 525-6

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Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe5a993d26c0933817d4bda56f52e7e6
https://hdl.handle.net/2066/154846

Systemic bioavailability of hydrofluoroalkane (HFA) formulations of fluticasone/salmeterol in healthy volunteers via pMDI alone and spacer

Autor: Karine L, Clearie, Peter A, Williamson, Sriram, Vaidyanathan, Jeannine, Du Bois, Haylene, Nell, Brian J, Lipworth

Publikováno v: British journal of clinical pharmacology. 69(6)

To compare a test version of HFA fluticasone/salmeterol (FP/SM) combination inhaler (Neolab, UK) with the reference product Seretide (GlaxoSmithKline, UK).An in vitro Anderson cascade impactor was used to compare the fine particle dose (4.7 microm).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::94f9e3a25fcecf53db0265779d1624a4
https://pubmed.ncbi.nlm.nih.gov/21453299