Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Jeannine R LaRocque"'
Autor:
Elizabeth L Graham, Joel Fernandez, Shagun Gandhi, Iqra Choudhry, Natalia Kellam, Jeannine R LaRocque
Publikováno v:
PLoS Genetics, Vol 20, Iss 4, p e1011250 (2024)
Accurate repair of DNA double-strand breaks (DSBs) is essential for the maintenance of genome integrity, as failure to repair DSBs can result in cell death. The cell has evolved two main mechanisms for DSB repair: non-homologous end-joining (NHEJ) an
Externí odkaz:
https://doaj.org/article/c3eb0c488c9d49ef87429ea51022eefd
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 9, Iss 11, Pp 3773-3780 (2019)
DNA double-strand breaks (DSBs) are especially toxic DNA lesions that, if left unrepaired, can lead to wide-ranging genomic instability. Of the pathways available to repair DSBs, the most accurate is homologous recombination (HR), where a homologous
Externí odkaz:
https://doaj.org/article/946cc2c36a24469cbc2ef0010ceec2de
Publikováno v:
Genes, Vol 12, Iss 9, p 1430 (2021)
DNA double-strand breaks (DSBs) are a particularly genotoxic type of DNA damage that can result in chromosomal aberrations. Thus, proper repair of DSBs is essential to maintaining genome integrity. DSBs can be repaired by non-homologous end joining (
Externí odkaz:
https://doaj.org/article/293991afb9f44ac7b35c367904a0ceec
Autor:
Jon-Philippe K. Hyatt, Lisa eNguyen, Allison E. Hall, Ashley M. Huber, Jessica C. Kocan, Julie A. Mattison, Rafael ede Cabo, Jeannine R. Larocque, Robert J. Talmadge
Publikováno v:
Frontiers in Physiology, Vol 7 (2016)
Shifts in myosin heavy chain (MHC) expression within skeletal muscle can be induced by a host of stimuli including, but not limited to, physical activity, alterations in neural activity, aging, and diet or obesity. Here, we hypothesized that both age
Externí odkaz:
https://doaj.org/article/b9d33b8a4180426aa1f0a57e40ab272b
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 9, Iss 11, Pp 3773-3780 (2019)
DNA double-strand breaks (DSBs) are especially toxic DNA lesions that, if left unrepaired, can lead to wide-ranging genomic instability. Of the pathways available to repair DSBs, the most accurate is homologous recombination (HR), where a homologous
Publikováno v:
Genes
Volume 12
Issue 9
Genes, Vol 12, Iss 1430, p 1430 (2021)
Volume 12
Issue 9
Genes, Vol 12, Iss 1430, p 1430 (2021)
DNA double-strand breaks (DSBs) are a particularly genotoxic type of DNA damage that can result in chromosomal aberrations. Thus, proper repair of DSBs is essential to maintaining genome integrity. DSBs can be repaired by non-homologous end joining (
Autor:
Nicholas Barnaba, Jeannine R. LaRocque
Publikováno v:
Cell Cycle
Disruption of cell cycle checkpoints has been well established as a hallmark of cancer. In particular, the G1-S transition mediated by the cyclin D-cyclin-dependent kinase 4/6 (CDK4/6) pathway is dysregulated in more than 90% of melanoma cases. There
Autor:
Madison Betcher, Pallavi Tatapudy, Rebecca L. Cox, Jeannine R. LaRocque, Romil K. Patel, Yaron Dayani, Carolyn M. Hofley
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Scientific Reports
Scientific Reports
RecQ helicases are a family of proteins involved in maintaining genome integrity with functions in DNA repair, recombination, and replication. The human RecQ helicase family consists of five helicases: BLM, WRN, RECQL, RECQL4, and RECQL5. Inherited m
Autor:
Jeannine R. LaRocque, Irene Chiolo, Carolyn M. Hofley, Elisa Jayne Bienenstock, Laetitia Delabaere, Faraz Sohail, Hans Sebastian, Henry A. Ertl, Dashiell J Massey
Publikováno v:
Aging Cell
Summary Aging is characterized by genome instability, which contributes to cancer formation and cell lethality leading to organismal decline. The high levels of DNA double‐strand breaks (DSBs) observed in old cells and premature aging syndromes are
Autor:
Keli Agama, Yves Pommier, Ronit I. Yarden, Jennifer Lapier, Hinanit Koltai, Christopher Albanese, Michael P. Croglio, Lucas Tricoli, Victor S. Wang, Jeannine R. LaRocque, Cristina Prandi, Colin P. Ryan, Emma Artuso, Jamie P. Schlarbaum, Yu Chen, Yaron Dayani, Jefferson M. Haake
Publikováno v:
Oncotarget
Strigolactones are a novel class of plant hormones produced in roots that regulate shoot and root development. We previously reported that strigolactone analogs (SLs) induce G2/M cell cycle arrest and apoptosis in a variety of human cancer cells and