FcRγ−NK cell induction by specific CMV and expansion by subclinical viral infections in rhesus macaques

Autor: Jaewon Lee, W. L. William Chang, Jeannine M. Scott, Suyeon Hong, Taehyung Lee, Jesse D. Deere, Peter Park, Ellen E. Sparger, Satya Dandekar, Dennis J. Hartigan-O’Connor, Peter A. Barry, Sungjin Kim

Long-lived ‘memory-like’ NK cells, characterized by FcRγ-deficiency and enhanced responsiveness to antibody-bound virus-infected cells, have been found in certain human cytomegalovirus (HCMV)-seropositive individuals. Because humans are exposed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::762fe7210929d76fa3880671e88aadc7
https://doi.org/10.1101/2022.05.26.493509

Adenovirus capsid-display of the retro-oriented human complement inhibitor DAF reduces Ad vector–triggered immune responses in vitro and in vivo

Autor: Haixiang Jiang, Jeannine M. Scott, Sergey S. Seregin, Andrea Amalfitano, Nathaniel J. Schuldt, Yasser A. Aldhamen, Zachary C. Hartman, Sarah Godbehere, Daniel M. Appledorn, Michael M. Frank

Publikováno v: Blood. 116:1669-1677

Adenovirus (Ad) vectors are widely used in human clinical trials. However, at higher dosages, Ad vector–triggered innate toxicities remain a major obstacle to many applications. Ad interactions with the complement system significantly contribute to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::433852e1bddb3563b3078c9e9352b56e
https://doi.org/10.1182/blood-2010-03-276949

Epigenetic modification and antibody-dependent expansion of memory-like NK cells in human cytomegalovirus-infected individuals

Autor: Tianxiang Zhang, Jaewon Lee, Min Jae Kim, Ilwoong Hwang, Jeannine M. Scott, Yosuke Kamimura, Lewis L. Lanier, Larissa Nitschke, Ahrom Kim, Sung Jin Kim

Publikováno v: Immunity, vol 42, iss 3
Lee, J; Zhang, T; Hwang, I; Kim, A; Nitschke, L; Kim, MJ; et al.(2015). Epigenetic modification and antibody-dependent expansion of memory-like NK cells in human cytomegalovirus-infected individuals. Immunity, 42(3), 431-442. doi: 10.1016/j.immuni.2015.02.013. UCSF: Retrieved from: http://www.escholarship.org/uc/item/1hb399jn

© 2015 Elsevier Inc. Long-lived "memory-like" NK cells have been identified in individuals infected by human cytomegalovirus (HCMV), but little is known about how the memory-like NK cell pool is formed. Here, we have shown that HCMV-infected individ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6dae533d5a7a565d300861a04059491
https://escholarship.org/uc/item/1hb399jn

Formation of FcRγ-deficient NK cell subset associated with HCMV-reactivation in hematopoietic cell transplant recipients

Autor: A. Samer Al-Homsi, Walter J. Esselman, Jeannine M. Scott, J. W. Lee, Stephanie F. Williams, Marlee Muilenburg, Sungjin Kim, Suyeon Hong

Publikováno v: Journal of Clinical Oncology. 35:131-131

131 Background: We have previously identified a novel subset of human NK cells that lacks FcRγ, a transmembrane signaling adaptor associated with CD16, the Fc receptor for IgG. These FcRγ-deficient NK cells (termed g-NK cells) display enhanced func

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::84f0f2053688303497efdf01c69a9911
https://doi.org/10.1200/jco.2017.35.7_suppl.131

Promoter-Proximal Poly(A) Sites Are Processed Efficiently, but the RNA Products Are Unstable in the Nucleus

Autor: Michael J. Imperiale, Jeannine M. Scott

Publikováno v: Molecular and Cellular Biology. 17:2127-2135

The presence of two polyadenylation signals in the primary transcript of the human immunodeficiency virus type 1 (HIV-1) provirus leads to a requirement for regulation of 3'-end processing. To ensure that viral genome replication and gene expression

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7492a1e2745d3303517b2a2510a2ac95
https://doi.org/10.1128/mcb.17.4.2127