Addition of 17-(allylamino)-17-demethoxygeldanamycin to a suboptimal caspofungin treatment regimen in neutropenic rats with invasive pulmonary aspergillosis delays the time to death but does not enhance the overall therapeutic efficacy.

Autor: Jeannine M Refos, Alieke G Vonk, Marian T Ten Kate, Kimberly Eadie, Henri A Verbrugh, Irma A J M Bakker-Woudenberg, Wendy W J van de Sande

Publikováno v: PLoS ONE, Vol 12, Iss 7, p e0180961 (2017)

Caspofungin (CAS) which is used as salvage therapy in patients with invasive pulmonary aspergillosis (IPA) inhibits the 1,3-β-D-glucan synthesis in Aspergillus fumigatus. Inhibiting 1,3-β-D-glucan synthesis induces a stress response and in an inver

Externí odkaz: https://doaj.org/article/7b3c30cc2c04459ab8905acaf7a8e8e4

Chitinase Induction Prior to Caspofungin Treatment of Experimental Invasive Aspergillosis in Neutropenic Rats Does Not Enhance Survival

Autor: Alieke G. Vonk, Marian T. ten Kate, Jeannine M. Refos, Irma A. J. M. Bakker-Woudenberg, Wendy W. J. van de Sande, Henri A. Verbrugh

Publikováno v: Antimicrobial Agents & Chemotherapy, 62(1):e00960-17. American Society for Microbiology

Host chitinases, chitotriosidase and acidic mammalian chitinase (AMCase), improved the antifungal activity of caspofungin (CAS) against Aspergillus fumigatus in vitro . These chitinases are not constitutively expressed in the lung. Here, we investiga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46a0417ec5e27fb694de458c7e784bb5
https://doi.org/10.1128/aac.00960-17

Double-Stranded RNA Mycovirus Infection of Aspergillus fumigatus Is Not Dependent on the Genetic Make-Up of the Host

Autor: Alieke G. Vonk, Jeannine M. Refos, Henri A. Verbrugh, Jerome R. Lo-Ten-Foe, Kimberly Eadie, Wendy W. J. van de Sande, Anne D. van Diepeningen

Publikováno v: PLoS ONE, 8(10):e77381. PUBLIC LIBRARY SCIENCE
PLoS One, 8(10). Public Library of Science
PLoS ONE, Vol 8, Iss 10, p e77381 (2013)
PLoS ONE
PLoS One (print), 8(10). Public Library of Science

Aspergillus fumigatus is a fungus that causes opportunistic infections in immunocompromised patients, with high morbidity and mortality. In its turn, A. fumigatus can become infected with mycoviruses. Most mycoviruses have a dsRNA genome and can caus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95ee735280baa1a1496d1bee02a7a53d
https://research.rug.nl/en/publications/8546440f-5cbd-48e7-a43e-bbfa0899453a