Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Jeannine Gerhardt"'
Autor:
Shuangyi Xu, Ning Wang, Michael V. Zuccaro, Jeannine Gerhardt, Rajan Iyyappan, Giovanna Nascimento Scatolin, Zongliang Jiang, Timour Baslan, Amnon Koren, Dieter Egli
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract DNA replication in differentiated cells follows a defined program, but when and how it is established during mammalian development is not known. Here we show using single-cell sequencing, that late replicating regions are established in asso
Externí odkaz:
https://doaj.org/article/d0fcd41651a2412d981b5ac0eabe1fdf
Autor:
Matthew M. Edwards, Ning Wang, Ido Sagi, Shay Kinreich, Nissim Benvenisty, Jeannine Gerhardt, Dieter Egli, Amnon Koren
Publikováno v:
Cell Reports, Vol 43, Iss 9, Pp 114700- (2024)
Summary: Genomic imprinting involves differential DNA methylation and gene expression between homologous paternal and maternal loci. It remains unclear, however, whether DNA replication also shows parent-of-origin-specific patterns at imprinted or ot
Externí odkaz:
https://doaj.org/article/2eb1152efe2f44a1a548ec7f56ff265b
Autor:
Advaitha Madireddy, Jeannine Gerhardt
Publikováno v:
STAR Protocols, Vol 4, Iss 4, Pp 102721- (2023)
Summary: Single-molecule analysis of replicated DNA (SMARD) is a unique technique that enables visualization of DNA replication at specific genomic regions at single-molecule resolution. Here, we present a protocol for visualizing DNA replication by
Externí odkaz:
https://doaj.org/article/559c3663b80e4f2fb23ece13c1a61704
Autor:
Qiliang Ding, Matthew M. Edwards, Ning Wang, Xiang Zhu, Alexa N. Bracci, Michelle L. Hulke, Ya Hu, Yao Tong, Joyce Hsiao, Christine J. Charvet, Sulagna Ghosh, Robert E. Handsaker, Kevin Eggan, Florian T. Merkle, Jeannine Gerhardt, Dieter Egli, Andrew G. Clark, Amnon Koren
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
The genetic basis of how cells replicate their DNA is not well understood. Here, the authors identify >1000 genetic elements that control human replication and reveal a complex epigenetic system that regulates replication origin activities.
Externí odkaz:
https://doaj.org/article/35d8b329749043bfb83a3cd38e9be893
Autor:
David Reichman, Limor Man, Laura Park, Raphael Lis, Jeannine Gerhardt, Zev Rosenwaks, Daylon James
Publikováno v:
Stem Cell Research, Vol 17, Iss 2, Pp 391-400 (2016)
During development, endothelial cells (EC) display tissue-specific attributes that are unique to each vascular bed, as well as generic signaling mechanisms that are broadly applied to create a patent circulatory system. We have previously utilized hu
Externí odkaz:
https://doaj.org/article/64bb1fbe3e42417395b4468bbf1fa3da
Autor:
Jeannine Gerhardt, Angela D. Bhalla, Jill Sergesketter Butler, James W. Puckett, Peter B. Dervan, Zev Rosenwaks, Marek Napierala
Publikováno v:
Cell Reports, Vol 16, Iss 5, Pp 1218-1227 (2016)
Friedreich’s ataxia (FRDA) is caused by the expansion of GAA repeats located in the Frataxin (FXN) gene. The GAA repeats continue to expand in FRDA patients, aggravating symptoms and contributing to disease progression. The mechanism leading to rep
Externí odkaz:
https://doaj.org/article/a3071ce6743c45e79f2475513624f78e
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 11 (2018)
The fragile X syndrome (FXS) is caused by a CGG repeat expansion at the fragile X mental retardation (FMR1) gene. FMR1 alleles with more than 200 CGG repeats bear chromosomal fragility when cells experience folate deficiency. CGG repeats were reporte
Externí odkaz:
https://doaj.org/article/8f626ba13b364a67b192f6fd2fa88383
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 10 (2017)
Fragile X syndrome (FXS), is caused by a loss-of-function mutation in the FMR1 gene located on the X-chromosome, which leads to the most common cause of inherited intellectual disability in males and the leading single-gene defect associated with aut
Externí odkaz:
https://doaj.org/article/43f127d6715645b495d3aff546c3fed3
Autor:
Angelica Barreto-Galvez, Mrunmai Niljikar, Julia Gagliardi, Ranran Zhang, Vasudha Kumar, Aastha Juruwala, Archana Pradeep, Anam Shaikh, Priyanka Tiwari, Kritika Sharma, Jeannine Gerhardt, Jian Cao, Keisuke Kataoka, Adam Durbin, Jun Qi, B. Hilda Ye, Advaitha Madireddy
Publikováno v:
bioRxiv
Mutations in the epigenetic regulator and global transcriptional activator, E1A binding protein (EP300), is being increasingly reported in aggressive hematological malignancies including adult T-cell leukemia/lymphoma (ATLL). However, the mechanistic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::418723b2d6e4c96acda18aa7fdbd11d3
https://europepmc.org/articles/PMC10168362/
https://europepmc.org/articles/PMC10168362/
Autor:
Joyce Hsiao, Ya Hu, Ning Wang, Amnon Koren, Andrew G. Clark, Alexa N. Bracci, Kevin Eggan, Florian T. Merkle, Michelle L Hulke, Matthew M. Edwards, Christine J. Charvet, Sulagna Ghosh, Dieter Egli, Qiliang Ding, Xiang Zhu, Robert E. Handsaker, Jeannine Gerhardt, Yao Tong
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications
Nature Communications
Funder: National Institute of Health (NIH) DP2-GM123495
DNA replication follows a strict spatiotemporal program that intersects with chromatin structure but has a poorly understood genetic basis. To systematically identify genetic regulators of
DNA replication follows a strict spatiotemporal program that intersects with chromatin structure but has a poorly understood genetic basis. To systematically identify genetic regulators of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66e3ee93deb4806288d949931a0bc770
https://doaj.org/article/35d8b329749043bfb83a3cd38e9be893
https://doaj.org/article/35d8b329749043bfb83a3cd38e9be893