Zobrazeno 1 - 10 of 30 pro vyhledávání: '"Jeannine, Lacroix"'
1
Akademický článek
Preclinical Testing of an Oncolytic Parvovirus in Ewing Sarcoma: Protoparvovirus H-1 Induces Apoptosis and Lytic Infection In Vitro but Fails to Improve Survival In Vivo
Autor: Jeannine Lacroix, Zoltán Kis, Rafael Josupeit, Franziska Schlund, Alexandra Stroh-Dege, Monika Frank-Stöhr, Barbara Leuchs, Jörg R. Schlehofer, Jean Rommelaere, Christiane Dinsart
Publikováno v: Viruses, Vol 10, Iss 6, p 302 (2018)
About 70% of all Ewing sarcoma (EWS) patients are diagnosed under the age of 20 years. Over the last decades little progress has been made towards finding effective treatment approaches for primarily metastasized or refractory Ewing sarcoma in young
Externí odkaz: https://doaj.org/article/2aae36d9e1f6498195aed00ddcd7999b
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2
Akademický článek
Preclinical Testing of an Oncolytic Parvovirus: Standard Protoparvovirus H-1PV Efficiently Induces Osteosarcoma Cell Lysis In Vitro
Autor: Carsten Geiss, Zoltán Kis, Barbara Leuchs, Monika Frank-Stöhr, Jörg R. Schlehofer, Jean Rommelaere, Christiane Dinsart, Jeannine Lacroix
Publikováno v: Viruses, Vol 9, Iss 10, p 301 (2017)
Osteosarcoma is the most frequent malignant disease of the bone. On the basis of early clinical experience in the 1960s with H-1 protoparvovirus (H-1PV) in osteosarcoma patients, this effective oncolytic virus was selected for systematic preclinical
Externí odkaz: https://doaj.org/article/1479ceeecb914cddaaed58655a7c486c
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3
Akademický článek
Pediatric and Adult High-Grade Glioma Stem Cell Culture Models Are Permissive to Lytic Infection with Parvovirus H-1
Autor: Rafael Josupeit, Sebastian Bender, Sonja Kern, Barbara Leuchs, Thomas Hielscher, Christel Herold-Mende, Jörg R. Schlehofer, Christiane Dinsart, Olaf Witt, Jean Rommelaere, Jeannine Lacroix
Publikováno v: Viruses, Vol 8, Iss 5, p 138 (2016)
Combining virus-induced cytotoxic and immunotherapeutic effects, oncolytic virotherapy represents a promising therapeutic approach for high-grade glioma (HGG). A clinical trial has recently provided evidence for the clinical safety of the oncolytic p
Externí odkaz: https://doaj.org/article/ca82147502634cddbddd5ee082649171
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4
Preclinical Testing of an Oncolytic Parvovirus in Ewing Sarcoma: Protoparvovirus H-1 Induces Apoptosis and Lytic Infection In Vitro but Fails to Improve Survival In Vivo
Autor: R Josupeit, Jörg R. Schlehofer, Jeannine Lacroix, Zoltán Kis, Barbara Leuchs, Alexandra Stroh-Dege, Monika Frank-Stöhr, Jean Rommelaere, Franziska Schlund, Christiane Dinsart
Publikováno v: Viruses
Volume 10
Issue 6
Viruses, Vol 10, Iss 6, p 302 (2018)
About 70% of all Ewing sarcoma (EWS) patients are diagnosed under the age of 20 years. Over the last decades little progress has been made towards finding effective treatment approaches for primarily metastasized or refractory Ewing sarcoma in young
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78fde1ed0495da6b2362a98e969b649b
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6
Oncolytic effects of parvovirus H-1 in medulloblastoma are associated with repression of master regulators of early neurogenesis
Autor: Barbara Leuchs, Franziska Schlund, Hendrik Witt, Olaf Witt, Jörg R. Schlehofer, Thomas Hielscher, Sebastian Bender, Dominik Sturm, Jean Rommelaere, Kathrin Adolph, Jeannine Lacroix, Stefan M. Pfister
Publikováno v: International Journal of Cancer. Journal International du Cancer
Based on extensive pre-clinical studies, the oncolytic parvovirus H-1 (H-1PV) is currently applied to patients with recurrent glioblastoma in a phase I/IIa clinical trial (ParvOryx01, NCT01301430). Cure rates of about 40% in pediatric high-risk medul
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40536a9f33063781433116bdc21ee600
http://europepmc.org/articles/PMC4232887
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8
Pediatric and Adult High-Grade Glioma Stem Cell Culture Models Are Permissive to Lytic Infection with Parvovirus H-1
Autor: Barbara Leuchs, R Josupeit, Thomas Hielscher, Olaf Witt, Jeannine Lacroix, Sonja Kern, Christiane Dinsart, Sebastian Bender, Jean Rommelaere, J�rg R. Schlehofer, Christel Herold-Mende
Publikováno v: Viruses; Volume 8; Issue 5; Pages: 138
Viruses
Viruses, Vol 8, Iss 5, p 138 (2016)
Combining virus-induced cytotoxic and immunotherapeutic effects, oncolytic virotherapy represents a promising therapeutic approach for high-grade glioma (HGG). A clinical trial has recently provided evidence for the clinical safety of the oncolytic p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db3db323f280161bd3471bb22ecf1560
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9
Parvovirus H1 selectively induces cytotoxic effects on human neuroblastoma cells
Autor: Olaf Witt, Hedwig E. Deubzer, Jean Rommelaere, Andreas E. Kulozik, Barbara Leuchs, Jeannine Lacroix, Jörg R. Schlehofer, Junwei Li, Georgi Hristov
Publikováno v: International Journal of Cancer. 127:1230-1239
Despite multimodal therapeutic concepts, advanced localized and high-risk neuroblastoma remains a therapeutic challenge with a long-term survival rate below 50%. Consequently, new modalities for the treatment of neuroblastoma, e.g., oncolytic virothe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::113247a4d8aafccf938b990a4178806f
https://doi.org/10.1002/ijc.25168
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