Zobrazeno 1 - 10
of 193
pro vyhledávání: '"Jeannie T, Lee"'
Autor:
Carlos Rivera, Hun-Goo Lee, Anna Lappala, Danni Wang, Verónica Noches, Montserrat Olivares-Costa, Marcela Sjöberg-Herrera, Jeannie T. Lee, María Estela Andrés
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The classical neuronal-gene corepressor RCOR1/CoREST is paradoxically enriched in transcriptionally active chromatin. Here the authors show RCOR1 is recruited during promoter-proximal pausing and negatively regulates the nascent-transcript synthesis.
Externí odkaz:
https://doaj.org/article/81f3099598404a4dbd4c6e911f8205fd
Autor:
Carlos Rivera, Daniel Verbel-Vergara, Duxan Arancibia, Anna Lappala, Marcela González, Fabián Guzmán, Gianluca Merello, Jeannie T. Lee, María Estela Andrés
Publikováno v:
Epigenetics & Chromatin, Vol 14, Iss 1, Pp 1-15 (2021)
Abstract Background Nuclear processes such as transcription and RNA maturation can be impacted by subnuclear compartmentalization in condensates and nuclear bodies. Here, we characterize the nature of nuclear granules formed by REST corepressor 2 (RC
Externí odkaz:
https://doaj.org/article/1e42156d4a4f407eafaaf66356ce3bbc
Autor:
Samuel Rivero-Hinojosa, Elena M. Pugacheva, Sungyun Kang, Claudia Fabiola Méndez-Catalá, Alexander L. Kovalchuk, Alexander V. Strunnikov, Dmitri Loukinov, Jeannie T. Lee, Victor V. Lobanenkov
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Although CTCF is a well-established 3D chromatin organizer in multicellular eukaryotes, relatively little is known about its male germ cell-specific paralogue, BORIS. Here the authors investigate how CTCF and BORIS interact and compensate in the male
Externí odkaz:
https://doaj.org/article/28f4c6cce58c4b69bfa80168060ded84
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
The nuclear pore complex components, nucleoporins, have been proposed to mediate spatial and temporal organization of chromatin. Here, the authors show that Nucleoporin 153 interacts with CTCF and cohesin, and mediates their binding across cis-regula
Externí odkaz:
https://doaj.org/article/4648e84dd657468790c7182b423f1e5e
Autor:
Jordan P. Lewandowski, James C. Lee, Taeyoung Hwang, Hongjae Sunwoo, Jill M. Goldstein, Abigail F. Groff, Nydia P. Chang, William Mallard, Adam Williams, Jorge Henao-Meija, Richard A. Flavell, Jeannie T. Lee, Chiara Gerhardinger, Amy J. Wagers, John L. Rinn
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
LncRNA loci potentially contain multiple modes that can exert function, including DNA regulatory elements. Here, the authors generated genetic models in mice to dissect the role of the syntenically conserved lncRNA Firre in the context of hematopoies
Externí odkaz:
https://doaj.org/article/ae0f94d7e6434786ac485113730f81c4
Publikováno v:
STAR Protocols, Vol 2, Iss 4, Pp 100819- (2021)
Summary: The isolation of protein-RNA complexes in the “denaturing cross-linked RNA immunoprecipitation” (dCLIP) protocol is based on biotin-tagging proteins of interest, UV cross-linking RNA to protein in vivo, RNase protection assay, and isolat
Externí odkaz:
https://doaj.org/article/b65798577737407a813672ec527aad2f
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
The inactive X (Xi)-specific S1/S2 chromosome compartments are merged by SMCHD1, but how the S1/S2 structure is constructed is unclear. The authors find that PRC1 drives the formation of S1/S2s and that the stepwise folding process of the Xi facilita
Externí odkaz:
https://doaj.org/article/c522349fbe6a426a81a63a1854f919b4
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-19 (2018)
The mammalian inactive X-chromosome (Xi) is organized into megadomains and superloops directed by the noncoding loci, Dxz4 and Firre. Here the authors provide evidence that megadomains do not precede Xist expression or Xi gene silencing, and suggest
Externí odkaz:
https://doaj.org/article/f77d839a60d344f6adff030162be5749
Publikováno v:
RNA. 29:463-472
Although more than 98% of the human genome is noncoding, nearly all drugs on the market target one of about 700 disease-related proteins. However, an increasing number of diseases are now being attributed to noncoding RNA and the ability to target th
Autor:
Ru-Xuan Tsai, Kuo-Chen Fang, Po-Cheng Yang, Yu-Hung Hsieh, I-Tien Chiang, Yunfei Chen, Hun-Goo Lee, Jeannie T Lee, Hsueh-Ping Catherine Chu
Publikováno v:
Nucleic Acids Research. 50:12217-12234
The genome consists of non-B-DNA structures such as G-quadruplexes (G4) that are involved in the regulation of genome stability and transcription. Telomeric-repeat containing RNA (TERRA) is capable of folding into G-quadruplex and interacting with ch