Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Jeannie F. Spagnolo"'
Enzymatic and nonenzymatic functions of viral RNA-dependent RNA polymerases within oligomeric arrays
Publikováno v:
RNA
Few antivirals are effective against positive-strand RNA viruses, primarily because the high error rate during replication of these viruses leads to the rapid development of drug resistance. One of the favored current targets for the development of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2065076c5fa910d60d0b5f387512ed20
Bypass Suppression of Small-Plaque Phenotypes by a Mutation in Poliovirus 2A That Enhances Apoptosis
Autor:
Trever B. Burgon, Stephen B. Deitz, Karla Kirkegaard, Jomaquai A. Jenkins, Jeannie F. Spagnolo
Publikováno v:
Journal of Virology. 83:10129-10139
The rate of protein secretion in host cells is inhibited during infection with several different picornaviruses, with consequences likely to have significant effects on viral growth, spread, and pathogenesis. This Sin + (secretion inhibition) phenoty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c45092877e114d205a59dc7b73c57bf5
https://doi.org/10.1128/jvi.00642-09
https://doi.org/10.1128/jvi.00642-09
Publikováno v:
Virology
The coronavirus nucleocapsid (N) protein is a major structural component of virions that associates with the genomic RNA to form a helical nucleocapsid. N appears to be a multifunctional protein since data also suggest that the protein may be involve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd256616027fe17a695602d49c2f2ea4
https://doi.org/10.1006/viro.2000.0611
https://doi.org/10.1006/viro.2000.0611
Autor:
Junying Yuan, Karla Kirkegaard, Ernesto Méndez, Roberto Mateo, Michael C. Rahe, Jeannie F. Spagnolo, Claude M. Nagamine, Michael Gale
Publikováno v:
Journal of virology. 87(3)
Autophagy is an important component of the innate immune response, directly destroying many intracellular pathogens. However, some pathogens, including several RNA viruses, subvert the autophagy pathway, or components of the pathway, to facilitate th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64ea368d4054fd911b875bd9f5770033
https://pubmed.ncbi.nlm.nih.gov/23175363
https://pubmed.ncbi.nlm.nih.gov/23175363
Autor:
Jeannie F. Spagnolo, Esther Bullitt, Elizabeth J. Tanner, Karla Kirkegaard, Andres B. Tellez, Jing Wang
Catalytic activities can be facilitated by ordered enzymatic arrays that co-localize and orient enzymes and their substrates. The purified RNA-dependent RNA polymerase from poliovirus self-assembles to form two-dimensional lattices, possibly facilita
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::300d35098acd5d0fccaf72ead6136f85
https://europepmc.org/articles/PMC3249232/
https://europepmc.org/articles/PMC3249232/
Autor:
Jeannie F. Spagnolo, Karla Kirkegaard, Oliver C. Richards, John M. Lyle, Susan E. Vleck, Robert D. Kuchta
The 22-amino-acid protein VPg can be uridylylated in solution by purified poliovirus 3D polymerase in a template-dependent reaction thought to mimic primer formation during RNA amplification in infected cells. In the cell, the template used for the r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30fd5ac402db21dbb73551e1e64afd42
https://europepmc.org/articles/PMC1563691/
https://europepmc.org/articles/PMC1563691/
Autor:
Olve B. Peersen, Karla Kirkegaard, Jeannie F. Spagnolo, Douglas L. Brutlag, Andres B. Tellez, Aaron Thompson, Scott Crowder
Publikováno v:
Journal of molecular biology. 357(2)
Poliovirus VPg is a 22 amino acid residue peptide that serves as the protein primer for replication of the viral RNA genome. VPg is known to bind directly to the viral RNA-dependent RNA polymerase, 3D, for covalent uridylylation, yielding mono and di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14f8c98e27dff704802b3ccf749f1d61
https://pubmed.ncbi.nlm.nih.gov/16427083
https://pubmed.ncbi.nlm.nih.gov/16427083
Autor:
Brenda G. Hogue, Jeannie F. Spagnolo
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9781461354987
The 3′ poly (A) tail plays an important, but as yet undefined role in Coronavirus genome replication. To further examine the requirement for the Coronavirus poly(A) tail, we created truncated poly(A) mutant defective interfering (DI) RNAs and obser
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46727a4d64a4a001a613e41fcb6d432f
https://doi.org/10.1007/978-1-4615-1325-4_68
https://doi.org/10.1007/978-1-4615-1325-4_68
Publikováno v:
Microscopy and Microanalysis. 14:1306-1307
Extended abstract of a paper presented at Microscopy and Microanalysis 2008 in Albuquerque, New Mexico, USA, August 3 – August 7, 2008
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c0c2d23636b604d274d10ea1e855763e
https://doi.org/10.1017/s1431927608082044
https://doi.org/10.1017/s1431927608082044