Zobrazeno 1 - 10
of 124
pro vyhledávání: '"Jeannie Chen"'
Autor:
Miranda L. Scalabrino, Mishek Thapa, Tian Wang, Alapakkam P. Sampath, Jeannie Chen, Greg D. Field
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract Retinitis pigmentosa is an inherited photoreceptor degeneration that begins with rod loss followed by cone loss. This cell loss greatly diminishes vision, with most patients becoming legally blind. Gene therapies are being developed, but it
Externí odkaz:
https://doaj.org/article/1aa9987457344b90b4f65e7efd14f6ff
Autor:
Miranda L Scalabrino, Mishek Thapa, Lindsey A Chew, Esther Zhang, Jason Xu, Alapakkam P Sampath, Jeannie Chen, Greg D Field
Publikováno v:
eLife, Vol 11 (2022)
Rod photoreceptor degeneration causes deterioration in the morphology and physiology of cone photoreceptors along with changes in retinal circuits. These changes could diminish visual signaling at cone-mediated light levels, thereby limiting the effi
Externí odkaz:
https://doaj.org/article/11077c6101994e839c93bc8cf9c3b56d
Autor:
J. Mario Isas, Nitin K. Pandey, Hui Xu, Kazuki Teranishi, Alan K. Okada, Ellisa K. Fultz, Anoop Rawat, Anise Applebaum, Franziska Meier, Jeannie Chen, Ralf Langen, Ansgar B. Siemer
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Huntingtin exon-1 (HTTex1) consists of a N-terminal N17 domain, the disease causing polyQ domain and a C-terminal proline-rich domain (PRD). Here, the authors combine electron paramagnetic resonance (EPR), solid-state NMR with other biophysical metho
Externí odkaz:
https://doaj.org/article/a3ad6629dcdc4912b80f4ba73af97d8a
Publikováno v:
Molecular Neurodegeneration, Vol 12, Iss 1, Pp 1-11 (2017)
Abstract Background Light exposure triggers movement of certain signaling proteins within the cellular compartments of the highly polarized rod photoreceptor cell. This redistribution of proteins between the inner and outer segment compartments affec
Externí odkaz:
https://doaj.org/article/121295a92347438ead7454286d137863
Publikováno v:
Bio-Protocol, Vol 9, Iss 14 (2019)
Rhodopsin is a G-protein coupled receptor (GPCR) that mediates vision under dim light. Upon light exposure, rhodopsin is phosphorylated at multiple serine and threonine sites at its carboxyl-terminus by rhodopsin kinase (GRK1). This, in turn, reduces
Externí odkaz:
https://doaj.org/article/356065837ed3494ca512b9ee0008a5d6
Autor:
Srimal Samaranayake, Xiufeng Song, Sergey A. Vishnivetskiy, Jeannie Chen, Eugenia V. Gurevich, Vsevolod V. Gurevich
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 11 (2018)
We determined the effects of different expression levels of arrestin-1-3A mutant with enhanced binding to light-activated rhodopsin that is independent of phosphorylation. To this end, transgenic mice that express mutant rhodopsin with zero, one, or
Externí odkaz:
https://doaj.org/article/836f3cb066a44190a2a22baa5dfb1828
Autor:
Frans Vinberg, Tian Wang, Alicia De Maria, Haiqing Zhao, Steven Bassnett, Jeannie Chen, Vladimir J Kefalov
Publikováno v:
eLife, Vol 6 (2017)
Calcium (Ca2+) plays an important role in the function and health of neurons. In vertebrate cone photoreceptors, Ca2+ controls photoresponse sensitivity, kinetics, and light adaptation. Despite the critical role of Ca2+ in supporting the function and
Externí odkaz:
https://doaj.org/article/ad538ebe229e424b9158b207f06f95da
Autor:
Anthony W Azevedo, Thuy Doan, Hormoz Moaven, Iza Sokal, Faiza Baameur, Sergey A Vishnivetskiy, Kristoff T Homan, John JG Tesmer, Vsevolod V Gurevich, Jeannie Chen, Fred Rieke
Publikováno v:
eLife, Vol 4 (2015)
Rod photoreceptors generate measurable responses to single-photon activation of individual molecules of the G protein-coupled receptor (GPCR), rhodopsin. Timely rhodopsin desensitization depends on phosphorylation and arrestin binding, which quenches
Externí odkaz:
https://doaj.org/article/4edccd85553d48d8a0ead6c6fbec1158
Publikováno v:
PLoS Genetics, Vol 10, Iss 7, p e1004480 (2014)
The neuronal calcium sensor proteins GCAPs (guanylate cyclase activating proteins) switch between Ca2+-free and Ca2+-bound conformational states and confer calcium sensitivity to guanylate cyclase at retinal photoreceptor cells. They play a fundament
Externí odkaz:
https://doaj.org/article/eaffac1574064f4a891832a629697df8
Autor:
Whitney M Cleghorn, Elviche L Tsakem, Xiufeng Song, Sergey A Vishnivetskiy, Jungwon Seo, Jeannie Chen, Eugenia V Gurevich, Vsevolod V Gurevich
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e22797 (2011)
Light-induced rhodopsin signaling is turned off with sub-second kinetics by rhodopsin phosphorylation followed by arrestin-1 binding. To test the availability of the arrestin-1 pool in dark-adapted outer segment (OS) for rhodopsin shutoff, we measure
Externí odkaz:
https://doaj.org/article/ae346e33b06e448385e7213e94667fa2