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Autor:
Pidder Jansen-Dürr, Kerstin Finke, Jürgen W. Botz, Martin Eilers, Philipp Steiner, Michele Pagano, Jeannette Wessbecher, Albrecht Meichle, Giulio Draetta
Publikováno v:
Proceedings of the National Academy of Sciences. 90:3685-3689
We have investigated the effects of deregulated expression of the human c-MYC protooncogene on cyclin gene expression and on the transcription factor E2F. We found that constitutive expression of MYC or activation of conditional MycER chimeras led to