Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Jeannette Nilsen"'
Autor:
Algirdas Grevys, Rahel Frick, Simone Mester, Karine Flem-Karlsen, Jeannette Nilsen, Stian Foss, Kine Marita Knudsen Sand, Thomas Emrich, Jens Andre Alexander Fischer, Victor Greiff, Inger Sandlie, Tilman Schlothauer, Jan Terje Andersen
Publikováno v:
iScience, Vol 25, Iss 2, Pp 103746- (2022)
Summary: Monoclonal IgG antibodies are the fastest growing class of biologics, but large differences exist in their plasma half-life in humans. Thus, to design IgG antibodies with favorable pharmacokinetics, it is crucial to identify the determinants
Externí odkaz:
https://doaj.org/article/af03cd0842d240c99a1d1d9176bb39cf
Autor:
Simone Mester, Mitchell Evers, Saskia Meyer, Jeannette Nilsen, Victor Greiff, Inger Sandlie, Jeanette Leusen, Jan Terje Andersen
Publikováno v:
mAbs, Vol 13, Iss 1 (2021)
Albumin has a serum half-life of 3 weeks in humans. This feature can be used to improve the pharmacokinetics of shorter-lived biologics. For instance, an albumin-binding domain (ABD) can be used to recruit albumin. A prerequisite for such design is t
Externí odkaz:
https://doaj.org/article/d68dea8700bb4629943b62d258a17e3a
Autor:
Algirdas Grevys, Jeannette Nilsen, Kine M. K. Sand, Muluneh B. Daba, Inger Øynebråten, Malin Bern, Martin B. McAdam, Stian Foss, Tilman Schlothauer, Terje E. Michaelsen, Gregory J. Christianson, Derry C. Roopenian, Richard S. Blumberg, Inger Sandlie, Jan Terje Andersen
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
The development of IgG and albumin-based therapeutics with increased half-lives needs more efficient screening procedures. Here the authors report a human endothelial cell-based recycling assay enabling screening of IgG and albumin variants without c
Externí odkaz:
https://doaj.org/article/99bc76e2016a473a870d99a7c561cd47
Autor:
Mattia Ferrarese, Francesco Bernardi, Mirko Pinotti, Alessio Branchini, Jeannette Nilsen, Kristin H Aaen, Torleif Tollefsrud Gjølberg, Silvia Lombardi, Jan Terje Andersen
Publikováno v:
British Journal of Haematology
Summary The short half‐life of coagulation factor IX (FIX) for haemophilia B (HB) therapy has been prolonged through fusion with human serum albumin (HSA), which drives the neonatal Fc receptor (FcRn)‐mediated recycling of the chimera. However, p
Autor:
Malin Bern, Aina Anthi, Sopisa Benjakul, Anette Kolderup, Eline Vaage, Heidrun Lode, Marina Vaysburd, Jeannette Nilsen, Mari Nyquist-Andersen, Siri Sakya, Torleif Gjølberg, Stian Foss, Morten Moe, Benjamin Low, Michael Wiles, John Vaage, Gunnveig Grodeland, Inger Sandlie, Leo James, Fridtjof Lund-Johansen, Jan Terje Andersen
While the established route for vaccines against the pandemic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is intramuscular, it may be preferable to deliver vaccines intranasally to secure mucosal protection at the site of infection.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf275ef065aa8fc7e4e49f90f6327e9d
https://doi.org/10.21203/rs.3.rs-1727649/v1
https://doi.org/10.21203/rs.3.rs-1727649/v1
Autor:
Bruno Sarmento, Cláudia Azevedo, Jeannette Nilsen, Algirdas Grevys, Jan Terje Andersen, Rute Nunes
Publikováno v:
Journal of Controlled Release. 327:161-173
Oral delivery of biopharmaceuticals, as insulin, is hampered by rapid degradation and inefficient absorption in the gastrointestinal tract (GIT). To solve this, a new class of biodegradable poly(lactic-co-glycolic)-poly(ethylene glycol) (PLGA-PEG) mu
Autor:
Malin C. Bern, Inger Sandlie, Kasper D. Rand, Cláudia Azevedo, Algirdas Grevys, Jan Terje Andersen, Jeannette Nilsen, Bjørn Dalhus, John J Wilson, Maria Stensland, Derry C. Roopenian, Stephen O. Brennan, Kine Marita Knudsen Sand, Esben Trabjerg
Publikováno v:
Communications Biology, Vol 3, Iss 1, Pp 1-11 (2020)
Nilsen, J, Trabjerg, E, Grevys, A, Azevedo, C, Brennan, S O, Stensland, M, Wilson, J, Sand, K M K, Bern, M, Dalhus, B, Roopenian, D C, Sandlie, I, Rand, K D & Andersen, J T 2020, ' An intact C-terminal end of albumin is required for its long half-life in humans ', Communications Biology, vol. 3, no. 1, 181 . https://doi.org/10.1038/s42003-020-0903-7
Communications Biology, 3 (1)
Communications Biology
Nilsen, J, Trabjerg, E, Grevys, A, Azevedo, C, Brennan, S O, Stensland, M, Wilson, J, Sand, K M K, Bern, M, Dalhus, B, Roopenian, D C, Sandlie, I, Rand, K D & Andersen, J T 2020, ' An intact C-terminal end of albumin is required for its long half-life in humans ', Communications Biology, vol. 3, no. 1, 181 . https://doi.org/10.1038/s42003-020-0903-7
Communications Biology, 3 (1)
Communications Biology
Albumin has an average plasma half-life of three weeks and is thus an attractive carrier to improve the pharmacokinetics of fused therapeutics. The half-life is regulated by FcRn, a cellular receptor that protects against intracellular degradation. T
Autor:
Fabian Brandl, Andreas Plückthun, Jan Terje Andersen, Jonas V. Schaefer, Uwe Zangemeister-Wittke, Martina Zimmermann, Kine Marita Knudsen Sand, Hannes Merten, Linda Irpinio, Jeannette Nilsen
Publikováno v:
Merten, Hannes; Brandl, Fabian; Zimmermann, Martina; Schaefer, Jonas V; Irpinio, Linda; Sand, Kine M K; Nilsen, Jeannette; Andersen, Jan Terje; Zangemeister-Wittke, Uwe; Plückthun, Andreas (2021). Half-life extension of efficiently produced DARPin serum albumin fusions as a function of FcRn affinity and recycling. European journal of pharmaceutics and biopharmaceutics, 167, pp. 104-113. Elsevier 10.1016/j.ejpb.2021.07.011
Serum albumin shows slow clearance from circulation due to neonatal Fc receptor (FcRn)-mediated recycling and has been used for half-life extension. We report here fusions to a high-affinity DARPin, binding to Epithelial Cell Adhesion Molecule (EpCAM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a66d7594c2edba3ba2962a0074777bc
https://www.zora.uzh.ch/id/eprint/210308/
https://www.zora.uzh.ch/id/eprint/210308/
Autor:
Algirdas Grevys, Rahel Frick, Simone Mester, Karine Flem-Karlsen, Jeannette Nilsen, Stian Foss, Kine Marita Knudsen Sand, Thomas Emrich, Jens Andre Alexander Fischer, Victor Greiff, Inger Sandlie, Tilman Schlothauer, Jan Terje Andersen
Publikováno v:
iScience
iScience, Vol 25, Iss 2, Pp 103746-(2022)
iScience, Vol 25, Iss 2, Pp 103746-(2022)
Summary Monoclonal IgG antibodies are the fastest growing class of biologics, but large differences exist in their plasma half-life in humans. Thus, to design IgG antibodies with favorable pharmacokinetics, it is crucial to identify the determinants
Autor:
Jeannette Nilsen, Inger Sandlie, Aina Karen Anthi, Kristin Hovden Aaen, Jan Terje Andersen, Simone Mester
Publikováno v:
Scandinavian Journal of Immunology. 93
The neonatal Fc receptor (FcRn) was first recognized for its role in transfer of maternal IgG to the fetus or newborn, providing passive immunity early in life. However, it has become clear that the receptor is versatile, widely expressed and plays a