Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Jeannette M Whitcomb"'
Autor:
Marilyn Lewis, Julie Mori, Jonathan Toma, Mike Mosley, Wei Huang, Paul Simpson, Roy Mansfield, Charles Craig, Elna van der Ryst, David L Robertson, Jeannette M Whitcomb, Mike Westby
Publikováno v:
PLoS ONE, Vol 13, Iss 12, p e0204099 (2018)
Detailed clonal phenotypic/genotypic analyses explored viral-escape mechanisms during maraviroc-based therapy in highly treatment-experienced participants from the MOTIVATE trials. To allow real-time assessment of samples while maintaining a blind tr
Externí odkaz:
https://doaj.org/article/e5fed03ceb034b1a93eda448a932be0c
Autor:
Rafal Mostowy, Roger D Kouyos, Ilka Hoof, Trevor Hinkley, Mojgan Haddad, Jeannette M Whitcomb, Christos J Petropoulos, Can Keşmir, Sebastian Bonhoeffer
Publikováno v:
PLoS Computational Biology, Vol 8, Iss 5, p e1002525 (2012)
Human immunodeficiency virus (HIV-1) is, like most pathogens, under selective pressure to escape the immune system of its host. In particular, HIV-1 can avoid recognition by cytotoxic T lymphocytes (CTLs) by altering the binding affinity of viral pep
Externí odkaz:
https://doaj.org/article/8f3336575b1246d68a87fa26b3fd2722
Autor:
Roger D Kouyos, Gabriel E Leventhal, Trevor Hinkley, Mojgan Haddad, Jeannette M Whitcomb, Christos J Petropoulos, Sebastian Bonhoeffer
Publikováno v:
PLoS Genetics, Vol 8, Iss 3, p e1002551 (2012)
Although fitness landscapes are central to evolutionary theory, so far no biologically realistic examples for large-scale fitness landscapes have been described. Most currently available biological examples are restricted to very few loci or alleles
Externí odkaz:
https://doaj.org/article/699a4bcabcb74c60bedcd6a4235f607a
Autor:
Roger D Kouyos, Viktor von Wyl, Trevor Hinkley, Christos J Petropoulos, Mojgan Haddad, Jeannette M Whitcomb, Jürg Böni, Sabine Yerly, Cristina Cellerai, Thomas Klimkait, Huldrych F Günthard, Sebastian Bonhoeffer, Swiss HIV Cohort Study
Publikováno v:
PLoS Pathogens, Vol 7, Iss 11, p e1002321 (2011)
HIV-1 replicative capacity (RC) provides a measure of within-host fitness and is determined in the context of phenotypic drug resistance testing. However it is unclear how these in-vitro measurements relate to in-vivo processes. Here we assess RCs in
Externí odkaz:
https://doaj.org/article/ac5e331eaef14db0a87440f062c39d55
Autor:
Dongmei Yang, Erkki Lathouwers, Richard E. Nettles, Lisa Stewart, Kimberley Brown, Jeannette M. Whitcomb
Publikováno v:
AIDS Research and Human Retroviruses
The emergence and transmission of antiretroviral drug resistance have been and remain a concern among people living with human immunodeficiency virus (HIV)-1 infection. The protease inhibitor (PI) darunavir has been approved for use in the United Sta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18fab8d41361b4a4c9da41211322f80d
http://europepmc.org/articles/PMC6306664
http://europepmc.org/articles/PMC6306664
Autor:
Claudia Vellozzi, Cecily Campbell, Lauren Canary, Randall Young, Jeannette M. Whitcomb, Harvey W. Kaufman, Susan Hariri
Publikováno v:
Clinical Infectious Diseases. 65:514-517
Using commercial laboratory data, we found 80% of 29382 young persons currently infected with hepatitis C virus lived >10 miles from a syringe services program. The median distance was 37 miles, with greater distances in rural areas and Southern and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9223d033792da4dace03a90c143e529
https://doi.org/10.1093/cid/cix333
https://doi.org/10.1093/cid/cix333
Autor:
Charles Craig, Jonathan Toma, Mike Mosley, Wei Huang, Roy Mansfield, Mike Westby, David Robertson, Paul Simpson, Jeannette M. Whitcomb, Marilyn Lewis, Julie Mori, Elna van der Ryst
Publikováno v:
PLoS ONE, Vol 13, Iss 12, p e0204099 (2018)
PLoS ONE
PLoS ONE
Detailed clonal phenotypic/genotypic analyses explored viral-escape mechanisms during maraviroc-based therapy in highly treatment-experienced participants from the MOTIVATE trials. To allow real-time assessment of samples while maintaining a blind tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a52d4f141be902a83898c2e43b058e7
https://doaj.org/article/e5fed03ceb034b1a93eda448a932be0c
https://doaj.org/article/e5fed03ceb034b1a93eda448a932be0c
Autor:
Wei Luo, Romeo R. Galang, Walid Heneine, Debra L. Hanson, Joan Duwve, Jeannette M. Whitcomb, Paula Peyrani, Philip J. Peters, Sara J. Blosser, S. Michele Owen, Pamela Pontones, Ron M. Kagan, Jessica Gentry, William M. Switzer, Anupama Shankar, Michael W. Spiller, Ellsworth M. Campbell, Hongwei Jia, Erika Chapman, Alexandra M. Oster, Silvina Masciotra, John T. Brooks, Jeremy C. Roseberry
Publikováno v:
The Journal of infectious diseases. 216(9)
In January 2015, an outbreak of undiagnosed human immunodeficiency virus (HIV) infections among persons who inject drugs (PWID) was recognized in rural Indiana. By September 2016, 205 persons in this community of approximately 4400 had received a dia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61c42f40e63b8d7be8cd1d56166ed918
https://pubmed.ncbi.nlm.nih.gov/29029266
https://pubmed.ncbi.nlm.nih.gov/29029266
Autor:
Max Lataillade, Megan Wind-Rotolo, George J. Hanna, Jeannette M. Whitcomb, Neelanjana Ray, Matthew D. Healy, Mark Krystal, Carey Hwang
Publikováno v:
JAIDS Journal of Acquired Immune Deficiency Syndromes. 64:7-15
Background BMS-663068 is the phosphonooxymethyl prodrug of BMS-626529, a small-molecule attachment inhibitor that targets the HIV-1 envelope glycoprotein gp120 preventing it from binding to CD4 T cells. In vitro investigations have demonstrated consi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21f7f46cdeb8a2d851a4270e5d586719
https://doi.org/10.1097/qai.0b013e31829726f3
https://doi.org/10.1097/qai.0b013e31829726f3
Autor:
Charles M Walworth, Jeannette M. Whitcomb, Mojgan Haddad, Christos J. Petropoulos, Joseph M. Volpe, Owen Solberg, Laura A Napolitano, A. Paquet
Publikováno v:
Antiviral Therapy. 19:435-441
Background Drug resistance testing and co-receptor tropism determination are key components of the management of antiretroviral therapy for HIV-1-infected individuals. The purpose of this study was to examine trends of HIV-1 resistance and viral evol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1c38c63399f7cf1f602bbd29ce51b73
https://doi.org/10.3851/imp2748
https://doi.org/10.3851/imp2748