Výsledky vyhledávání - "Jeannette Lo"

Akademický článek

Evaluation of in vitro Assays to Assess the Modulation of Dendritic Cells Functions by Therapeutic Antibodies and Aggregates

Autor: Hannah Morgan, Su-Yi Tseng, Yann Gallais, Margret Leineweber, Pascale Buchmann, Sabrina Riccardi, Myriam Nabhan, Jeannette Lo, Zaahira Gani, Natacha Szely, Cornelia S. Zhu, Ming Yang, Andrea Kiessling, Hans-Werner Vohr, Marc Pallardy, Fred Aswad, Isabelle Turbica

Publikováno v: Frontiers in Immunology, Vol 10 (2019)

Therapeutic antibodies have the potential to induce immunogenicity leading to the development of anti-drug antibodies (ADA) that consequently may result in reduced serum drug concentrations, a loss of efficacy or potential hypersensitivity reactions.

Externí odkaz: https://doaj.org/article/92890ae12e7f4f51abedf6bb53bf3d43

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Akademický článek

Immature Dendritic Cell Therapy Confers Durable Immune Modulation in an Antigen-Dependent and Antigen-Independent Manner in Nonobese Diabetic Mice

Autor: Jeannette Lo, Chang-Qing Xia, Ruihua Peng, Michael J. Clare-Salzler

Publikováno v: Journal of Immunology Research, Vol 2018 (2018)

Dendritic cell (DC) immunotherapy has been effective for prevention of type 1 diabetes (T1D) in NOD mice but fails to protect if initiated after active autoimmunity. As autoreactivity expands inter- and intramolecularly during disease progression, we

Externí odkaz: https://doaj.org/article/4ee8600c2aad496690d43d4035d6e969

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MO207: A Phase 1/2, Multicenter Study to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of BION-1301 in Healthy Volunteers and Adults with IGA Nephropathy

Autor: Jonathan Barratt, Brian Schwartz, Bess Sorensen, Margaret Macdonald, Jerlyn Tolentino, Jeannette Lo, Andrew King, Sai Prasad N Iyer, Alan Glicklich

Publikováno v: Nephrology Dialysis Transplantation. 37

BACKGROUND AND AIMS Immunoglobulin A nephropathy (IgAN) is the leading cause of primary glomerulonephritis worldwide with limited treatment options, especially for high-risk patients [1]. BION-1301 is a novel humanized monoclonal antibody that blocks

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7eff415ea219e8776e1c0ac89b37a558
https://doi.org/10.1093/ndt/gfac067.006

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MO212: Updated Interim Results of A Phase 1/2 Study to Investigate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Clinical Activity of BION-1301 in Patients With IGA Nephropathy

Autor: Jonathan Barratt, Laura Kooienga, Billy Hour, Irfan Agha, Brian Schwartz, Bess Sorensen, Jeannette Lo, Andrew King, Taher Sathaliya, Sai Prasad N Iyer, Aaron Endsley, Alan Glicklich

Publikováno v: Nephrology Dialysis Transplantation. 37

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0256392901e59f872f5fd8a4e7d6e621
https://doi.org/10.1093/ndt/gfac067.011

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MO286DESIGN OF A PH1, MULTICENTER TRIAL TO INVESTIGATE THE SAFETY, TOLERABILITY, PK/PD OF BION-1301 IN HEALTHY VOLUNTEERS AND ADULTS WITH IGAN AND A MULTICENTER, OPEN-LABEL EXTENSION STUDY FOR IGAN PATIENTS WHO PARTICIPATED IN A PRIOR TRIAL OF BION-1301

Autor: Jeannette Lo, Jonathan Barratt, Suzanne Roy, Alan Glicklich, Cailin Sibley, Angelique Mittan, Colleen Stromatt, Aaron Endsley

Publikováno v: Nephrology Dialysis Transplantation. 36

Background and Aims IgA nephropathy (IgAN), the leading cause of primary glomerulonephritis, is an autoimmune disease with no approved treatments.1 Progression to end-stage-renal disease occurs in up to 45% of IgAN patients, requiring dialysis or kid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2c14d45ad7ee6666251029ffdb6fc630
https://doi.org/10.1093/ndt/gfab104.0044

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FC 040INTERIM RESULTS OF PHASE 1 AND 2 TRIALS TO INVESTIGATE THE SAFETY, TOLERABILITY, PHARMACOKINETICS, PHARMACODYNAMICS, AND CLINICAL ACTIVITY OF BION-1301 IN PATIENTS WITH IGA NEPHROPATHY

Autor: Suzanne Roy, Alan Glicklich, Cailin Sibley, Jonathan Barratt, Billy Hour, Aaron Endsley, Angelique Mittan, Colleen Stromatt, Jeannette Lo

Publikováno v: Nephrology Dialysis Transplantation. 36

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::42af3eafca78bc828b04770a0dd61003
https://doi.org/10.1093/ndt/gfab117.004

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P0500RESULTS OF A PHASE 1 TRIAL TO INVESTIGATE THE SAFETY, TOLERABILITY, PHARMACOKINETICS, AND PHARMACODYNAMICS OF BION-1301 IN HEALTHY VOLUNTEERS

Autor: Aaron Endsley, Thomas Müller, Jeannette Lo, Somayeh Honarmand, Jonathan Barratt, David Essayan, Angelique Mittan, Jos van de Crommert, Peter van Zandvoort, Jackie Walling

Publikováno v: Nephrology Dialysis Transplantation. 35

Background and Aims IgA nephropathy (IgAN), the leading cause of primary glomerulonephritis, is an autoimmune disease with no approved treatments. Slow progression to end-stage-renal disease occurs in up to 50% of patients with IgAN over approximatel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ec92294863b89230ae3f4999ebb094d4
https://doi.org/10.1093/ndt/gfaa142.p0500

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P0379BION-1301, A FULLY BLOCKING ANTIBODY TARGETING APRIL FOR THE TREATMENT OF IGA NEPHROPATHY: ASSESSMENT OF SAFETY, PHARMACOKINETICS AND PHARMACODYNAMICS IN LONG-TERM NONCLINICAL STUDIES

Autor: Peter van Zandvoort, Aaron Endsley, Joost Kreijtz, Andrea van Elsas, Veronique Lauriault, Jeannette Lo, Jos van de Crommert, Maarten Friesen, Thomas F. Mueller

Publikováno v: Nephrology Dialysis Transplantation. 35

Background and Aims IgA Nephropathy (IgAN) is a common form of glomerulonephritis and its pathogenesis is thought to consist of sequential pathogenic hits, including the production of auto-antigen galactose-deficient IgA1 (Gd-IgA1) and auto-antibody

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e228a477883ffa43bd749684d2164fcd
https://doi.org/10.1093/ndt/gfaa142.p0379

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Discovery, Total Synthesis and Key Structural Elements for the Immunosuppressive Activity of Cocosolide, a Symmetrical Glycosylated Macrolide Dimer from Marine Cyanobacteria

Autor: Jeannette Lo, Michael J. Clare-Salzler, Sarath P. Gunasekera, Tao Ye, Hendrik Luesch, Joseph H. Reibenspies, Yang Li, Ranjala Ratnayake, Zhengshuang Xu, Danmeng Luo, Valerie J. Paul

Publikováno v: Chemistry - A European Journal. 22:8158-8166

A new dimeric macrolide xylopyranoside, cocosolide (1), was isolated from the marine cyanobacterium preliminarily identified as Symploca sp. from Guam. The structure was determined by a combination of NMR spectroscopy, HRMS, X-ray diffraction studies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bb715e146225052eda9d48fdcf58e5e
https://doi.org/10.1002/chem.201600674

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Evaluation of

Publikováno v: Frontiers in Immunology
Frontiers in Immunology, Vol 10 (2019)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::37b961c97b9284d1371c97981bbc3711
https://pubmed.ncbi.nlm.nih.gov/31001248

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