Zobrazeno 1 - 10 of 19 pro vyhledávání: '"Jeannette Bannink"'
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Abstract 2380: Preclinical safety and efficacy of a tumor-directed T cell activating 4-1BB x 5T4 ADAPTIR™ bispecific antibody
Autor: Michelle H. Nelson, Anna Dahlman, Starrla Johnson, Cathy McMahan, Adnan Deronic, Peter Ellmark, Gabriele Blahnik-Fagan, Jeannette Bannink, Sara Fritzell, Gabriela Hernandez-Hoyos, Doreen Werchau, Lill Ljung, Robert Bader, Anneli Nilsson, Maria Askmyr
Publikováno v: Cancer Research. 79:2380-2380
The ability to induce potent anti-tumor activity by stimulating 4-1BB (CD137), a key co-stimulatory receptor, makes 4-1BB an attractive immunotherapeutic target. However, a clinically tested, 4-1BB targeting monospecific antibody has been hampered by
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aed1f37952c67c77da00ae9e80ab7ee7
https://doi.org/10.1158/1538-7445.am2019-2380
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Activation of the CD137 Pathway in T cells by a CD137 × 5T4 bispecific ADAPTIR Molecule Requires Co-engagement of CD137 and 5T4
Autor: Gabriele R. Blahnik-Fagan, Robert Bader, Jeannette Bannink, Danielle Mitchell, Lynda Misher, Cathy McMahan, David Bienvenue, Sara Fritzell, Anna Säll, Laura von Schantz, Peter Ellmark, Michelle Nelson, Gabriela Hernandez-Hoyos
Publikováno v: The Journal of Immunology. 200:58.21-58.21
CD137 (4-1BB) is a key costimulatory immune receptor (member of the TNFR-superfamily) that is expressed primarily on activated CD8+ T and NK cells. Stimulation of CD137 leads to enhanced proliferation, increased survival, intensified cytolytic activi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0be3927d79fa6f33e3277823ebea66b4
https://doi.org/10.4049/jimmunol.200.supp.58.21
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7
Abstract B111: Characterization of APVO436, a bispecific anti-CD123 x anti-CD3 ADAPTIR™ molecule for redirected T-cell cytotoxicity, in preclinical models of AML and nonhuman primates
Autor: Rebecca Gottschalk, Catherine J. McMahan, David Bienvenue, Michael R. Comeau, Danielle Mitchell, Robert Bader, Robert E. Miller, Jeannette Bannink, Gabriela H. Hoyos, Jane A. Gross, Lynda Misher, Melissa DeFrancesco, Starrla Johnson, Lara Parr
Publikováno v: Molecular Cancer Therapeutics. 17:B111-B111
Introduction: CD123 has emerged as a promising target for T-cell directed immunotherapy in acute myeloid leukemia due to its high level of expression on leukemic blasts and stem cells and low frequency of expression on normal cell types. CD123 is exp
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::50248cbfb3642634d0a61f3e49ac65ff
https://doi.org/10.1158/1535-7163.targ-17-b111
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8
Pharmacokinetic and pharmacodynamic properties of TRU-015, a CD20-directed small modular immunopharmaceutical protein therapeutic, in patients with rheumatoid arthritis: A phase I, open-label, dose-escalation clinical study
Autor: Daniel Burge, Cathye Shu, Roy Fleischmann, Jeannette Bannink, Stephen A. Bookbinder, Alan Kivitz
Publikováno v: Clinical Therapeutics. 30:1806-1816
Background : TRU-015 is a small modular immunopharmaceutical protein drug that binds to CD20 and effectively depleted B cells in nonhuman primates. Objective : The aim of this clinical study was to determine the pharmacokinetic (PK) and pharmacodynam
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9b73ab432db355509b56c00bf92ed77
https://doi.org/10.1016/j.clinthera.2008.10.017
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Characterization of a Proapoptotic Antiganglioside GM2 Monoclonal Antibody and Evaluation of Its Therapeutic Effect on Melanoma and Small Cell Lung Carcinoma Xenografts
Autor: Karen Dresser, Jeannette Bannink, Feng Cai, Gary R. Fanger, David W Peckham, Kenneth L. Rock, Jeffrey C. Johnson, Bruce A. Woda, Marc W. Retter, Neil Fanger, Teresa M. Foy, Chaitanya S. Bangur
Publikováno v: Cancer Research. 65:6425-6434
Monoclonal antibodies have begun to show great clinical promise for the treatment of cancer. Antibodies that can directly affect a tumor cell's growth and/or survival are of particular interest for immunotherapy. Previously, we described monoclonal a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb6e3f3275fd244b3c4ded8d2d899edb
https://doi.org/10.1158/0008-5472.can-05-0300
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10
Derivation and characterization of a highly pathogenic isolate of human immunodeficiency virus type 2 that causes rapid CD4+ cell depletion in Macaca nemestrina
Autor: William R. Morton, Jeannette Bannink, Ann Schmidt, David M. Anderson, Janela McClure, Che Chung Tsai, Marie Anne Rey-Cuille, Lynda Misher, Shiu Lok Hu
Publikováno v: Journal of Medical Primatology. 29:114-126
With few exceptions, humans are the only species known to develop acquired immunodeficiency syndrome (AIDS) after human immunodeficiency virus (HIV) infection. We report here that an isolate of HIV type 2, EHO, readily established persistent infectio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::24991a5fdd523fda7c6ff8cd539e426c
https://doi.org/10.1034/j.1600-0684.2000.290304.x
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