Zobrazeno 1 - 10
of 579
pro vyhledávání: '"Jeanne Y. Wei"'
Publikováno v:
Biology, Vol 13, Iss 3, p 172 (2024)
Interleukin-1β converting enzyme (ICE, caspase-1) is a thiol protease that cleaves the pro-inflammatory cytokine precursors of IL-1β and IL-18 into active forms. Given the association between caspase-1 and cardiovascular pathology, we analyzed the
Externí odkaz:
https://doaj.org/article/2671ba74da2c46478a3d9c58339211d8
Publikováno v:
Cells, Vol 13, Iss 5, p 392 (2024)
RhoA-regulated gene transcription by serum response factor (SRF) and its transcriptional cofactor myocardin-related transcription factors (MRTFs) signaling pathway has emerged as a promising therapeutic target for pharmacological intervention in mult
Externí odkaz:
https://doaj.org/article/355fcaaeb31b4fcd97d83dce059828ba
Autor:
Ambika Verma, Gohar Azhar, Xiaomin Zhang, Pankaj Patyal, Grishma Kc, Shakshi Sharma, Yingni Che, Jeanne Y. Wei
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 2, p 950 (2023)
Porphyromonas gingivalis (P. gingivalis), a key pathogen in periodontitis, is associated with neuroinflammation. Periodontal disease increases with age; 70.1% of adults 65 years and older have periodontal problems. However, the P. gingivalis- lipopol
Externí odkaz:
https://doaj.org/article/6f15cc179fa5450fb12681bf62d89c1e
Autor:
Valentina K. Todorova, Eric R. Siegel, Yihong Kaufmann, Asangi Kumarapeli, Aaron Owen, Jeanne Y. Wei, Issam Makhoul, V. Suzanne Klimberg
Publikováno v:
Translational Oncology, Vol 13, Iss 2, Pp 471-480 (2020)
Dysregulation of calcium homeostasis is a major mechanism of doxorubicin (DOX)-induced cardiotoxicity. Treatment with DOX causes activation of sarcoplasmic reticulum (SR) ryanodine receptor (RYR) and rapid release of Ca2+ in the cytoplasm resulting i
Externí odkaz:
https://doaj.org/article/8ce64e1bb5c54f67a276054e815fed5a
Autor:
Pankaj Patyal, Bachkhoa Nguyen, Xiaomin Zhang, Gohar Azhar, Fathima S. Ameer, Ambika Verma, Jasmine Crane, Grishma KC, Yingni Che, Jeanne Y. Wei
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 19, p 11536 (2022)
CCG-1423 is a Rho A pathway inhibitor that has been reported to inhibit Rho/SRF-mediated transcriptional regulation. Serum response factor and its cofactors, which include ternary complex factors and myocardin-related transcription factors, regulate
Externí odkaz:
https://doaj.org/article/8a7d2c297d6d45e1af3d7744d48f842f
Autor:
Stephanie R. Dayer MD, Simon C. Mears MD, PhD, Amanda K. Pangle BS, Priya Mendiratta MD, MPH, Jeanne Y. Wei MD, Gohar Azhar MD
Publikováno v:
Geriatric Orthopaedic Surgery & Rehabilitation, Vol 12 (2021)
Introduction Public health achievements throughout the last century have resulted in a steady increase in life expectancy. An emergent subset has distinguished themselves, living well beyond the ninth decade by avoiding or delaying the onset of most
Externí odkaz:
https://doaj.org/article/b51bb514914d421fa6bbe5c64ee9000c
Publikováno v:
Gerontology and Geriatric Medicine, Vol 7 (2021)
Cardiovascular disease is a common comorbidity associated with an aging population. However, there is a unique group of individuals whose age-defying qualities are still being investigated. This retrospective chart review analyzed various cardiac and
Externí odkaz:
https://doaj.org/article/2d358dd58ad943e89d4becfd292d71d4
Autor:
Gohar Azhar, Sakeena Raza, Amanda Pangle, Kellie Coleman, Amanda Dawson, Amy Schrader, Robert R. Wolfe, Jeanne Y. Wei
Publikováno v:
Gerontology and Geriatric Medicine, Vol 6 (2020)
Approximately half of heart failure patients in the US have heart failure with preserved ejection fraction (HFpEF). HFpEF impairs physical performance and thus reduces quality of life. Increasing dietary protein intake can increase lean body mass and
Externí odkaz:
https://doaj.org/article/0caa3bf9c764490e862def35fdd29f61
Autor:
Michael A. Bauer, Valentina K. Todorova, Annjanette Stone, Weleetka Carter, Matthew D. Plotkin, Ping-Ching Hsu, Jeanne Y. Wei, Joseph L. Su, Issam Makhoul
Publikováno v:
Cancers, Vol 13, Iss 24, p 6291 (2021)
Chemotherapy with doxorubicin (DOX) may cause unpredictable cardiotoxicity. This study aimed to determine whether the methylation signature of peripheral blood mononuclear cells (PBMCs) prior to and after the first cycle of DOX-based chemotherapy cou
Externí odkaz:
https://doaj.org/article/f180200810f44e4c8efb67a5ad409fea
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 2, p 473 (2021)
Alternative splicing generates multiple distinct isoforms that increase transcriptome and proteome diversity. There are seven sirtuin genes in humans, each consists of multiple exons that are likely to undergo alternative splicing. Our aim was to cha
Externí odkaz:
https://doaj.org/article/6fe69740e7af4eba90edee2e80e6c66d