Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Jeanne S. Chang"'
Autor:
Zachary Lee Johnson, Mark Ammirati, David Jonathan Wasilko, Jeanne S. Chang, Stephen Noell, Timothy L. Foley, Hyejin Yoon, Kathleen Smith, Shoh Asano, Katherine Hales, Min Wan, Qingyi Yang, Mary A. Piotrowski, Kathleen A. Farley, Tamara Gilbert, Lisa M. Aschenbrenner, Kimberly F. Fennell, Jason K. Dutra, Mary Xu, Chunyang Guo, Alison E. Varghese, Justin Bellenger, Alandra Quinn, Christopher W. am Ende, Graham M. West, Matthew C. Griffor, Donald Bennett, Matthew Calabrese, Claire M. Steppan, Seungil Han, Huixian Wu
Publikováno v:
Nature Structural & Molecular Biology. 30:22-30
Glycerol-3-phosphate acyltransferase (GPAT)1 is a mitochondrial outer membrane protein that catalyzes the first step of de novo glycerolipid biosynthesis. Hepatic expression of GPAT1 is linked to liver fat accumulation and the severity of nonalcoholi
Autor:
Ariamala Gopalsamy, Ann E. Aulabaugh, Amey Barakat, Kevin C. Beaumont, Shawn Cabral, Daniel P. Canterbury, Agustin Casimiro-Garcia, Jeanne S. Chang, Ming Z. Chen, Chulho Choi, Robert L. Dow, Olugbeminiyi O. Fadeyi, Xidong Feng, Scott P. France, Roger M. Howard, Jay M. Janz, Jayasankar Jasti, Reema Jasuja, Lyn H. Jones, Amanda King-Ahmad, Kelly M. Knee, Jeffrey T. Kohrt, Chris Limberakis, Spiros Liras, Carlos A. Martinez, Kim F. McClure, Arjun Narayanan, Jatin Narula, Jonathan J. Novak, Thomas N. O’Connell, Mihir D. Parikh, David W. Piotrowski, Olga Plotnikova, Ralph P. Robinson, Parag V. Sahasrabudhe, Raman Sharma, Benjamin A. Thuma, Dipy Vasa, Liuqing Wei, A. Zane Wenzel, Jane M. Withka, Jun Xiao, Hatice G. Yayla
Publikováno v:
Journal of Medicinal Chemistry. 64:326-342
Sickle cell disease (SCD) is a genetic disorder caused by a single point mutation (β6 Glu → Val) on the β-chain of adult hemoglobin (HbA) that results in sickled hemoglobin (HbS). In the deoxygenated state, polymerization of HbS leads to sickling
Autor:
Lori Krim Gavrin, David Hepworth, Jennifer R. Thomason, Iain Kilty, Joel Adam Goldberg, Christoph W. Zapf, Vikram R. Rao, Brian P. Boscoe, Akshay Patny, Peter T. Symanowicz, Marina W.H. Shen, Kevin J. Curran, Elizabeth Murphy, Martin Hegen, Fabien Vincent, Richard Vargas, Satwik Kamtekar, Heidi M. Morgan, Heidi R. Hope, Richard K. Frisbie, Jeanne S. Chang, Ken Dower, Susan E. Drozda, Strohbach Joseph Walter, Mathias John Paul, David R. Anderson, Jacqueline E. Day, Stephen W. Wright, Ivan J. Samardjiev, Seungil Han, Julia H Shin, Frank Lovering, Andrea G Bree, Arthur Lee, Holly H. Soutter, Joanne Brodfuehrer, John David Trzupek, Brian Samas, Christoph Martin Dehnhardt, Michael Dennis Lowe, Catherine M. Ambler, Seung Won Chung, Eddine Saiah, Nikolaos Papaioannou, Pierce Betsy S, Jiangli Yan, Katherine L. Lee, Lih-Ling Lin, Chulho Choi
Publikováno v:
Journal of Medicinal Chemistry. 60:5521-5542
Through fragment-based drug design focused on engaging the active site of IRAK4 and leveraging three-dimensional topology in a ligand-efficient manner, a micromolar hit identified from a screen of a Pfizer fragment library was optimized to afford IRA
Autor:
Steven H. Liang, Jinshan Michael Chen, Marc D. Normandin, Jeanne S. Chang, George C. Chang, Christine K. Taylor, Patrick Trapa, Mark S. Plummer, Kimberly S. Para, Edward L. Conn, Lori Lopresti‐Morrow, Lorraine F. Lanyon, James M. Cook, Karl E. G. Richter, Charlie E. Nolan, Joel B. Schachter, Fouad Janat, Ye Che, Veerabahu Shanmugasundaram, Bruce A. Lefker, Bradley E. Enerson, Elijahu Livni, Lu Wang, Nicolas J. Guehl, Debasis Patnaik, Florence F. Wagner, Roy Perlis, Edward B. Holson, Stephen J. Haggarty, Georges El Fakhri, Ravi G. Kurumbail, Neil Vasdev
Publikováno v:
Angewandte Chemie. 128:9753-9757
Autor:
Kevin Beaumont, Dharani Rao, Amey Barakat, David W. Piotrowski, Jay Jasti, Parag Sahasrabudhe, Jeanne S. Chang, Jay M. Janz, Zane Wenzel, Reema Jasuja, Kelly M. Knee, Jatin Narula
Publikováno v:
Blood. 134:207-207
Sickle cell disease (SCD) is a severe genetic disorder caused by a single point mutation on the β-chain of adult hemoglobin (Hb A), β6 Glu→Val (Hb S). In the deoxygenated state Hb S polymerizes, leading to RBC sickling and precipitating all downs
Autor:
Suman Luthra, Graham M. West, Jeremy T. Starr, Matthew Frank Brown, Matthew F. Calabrese, Jinshan Chen, Hongyao Zhu, Xiayang Qiu, Daniel P. Uccello, Matthew Merrill Hayward, Jeanne S. Chang, Jotham Wadsworth Coe, Kathleen A. Farley, Kris A. Borzilleri, Mark C. Noe, Justin I. Montgomery, Adam M. Gilbert, Veerabahu Shanmugasundaram, Lara C. Czabaniuk, Robert M. Oliver, Carmen N. Garcia-Irrizary, Brandon P. Schuff, Chuong Nguyen, Yingrong Xu, James Schiemer, Jaymin C. Shah, Xidong Feng, Mark Niosi, Jennifer A. Young, WeiDong Ding, Ayman El-Kattan, Adelajda Zorba, James F. Smith
Proteolysis targeting chimeras (PROTACs) are heterobifunctional small molecules that simultaneously bind to a target protein and an E3 ligase, thereby leading to ubiquitination and subsequent degradation of the target. They present an exciting opport
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf434de63be490efb6416cf59a222839
https://europepmc.org/articles/PMC6077745/
https://europepmc.org/articles/PMC6077745/
Autor:
Seungil Han, Katarina S. Midelfort, Marie Anderson, Jeanne S. Chang, Jeremy Minshull, Alan Villalobos, Michael J. Karmilowicz, Rajesh Kumar, Daniel K. Gehlhaar, Kevin McConnell, Anil Mistry, John W. Wong, Sridhar Govindarajan
Publikováno v:
Protein Engineering Design and Selection. 26:25-33
Several protein engineering approaches were combined to optimize the selectivity and activity of Vibrio fluvialis aminotransferase (Vfat) for the synthesis of (3S,5R)-ethyl 3-amino-5-methyloctanoate; a key intermediate in the synthesis of imagabalin,
Autor:
Julie Lee, Paul Alan Glossop, Atli Thorarensen, Yogesh A. Sabnis, Christopher Phillips, Lori Fitz, Frank Lovering, Andrew F. Bent, Ravi G. Kurumbail, Gavin A. Whitlock, Jeanne S. Chang, Seungil Han, Joseph J. McDonald, Mark Ryan
Publikováno v:
Chemical Biology & Drug Design. 80:657-664
Spleen tyrosine kinase is a non-receptor tyrosine kinase, overactivation of which is thought to contribute to autoimmune diseases as well as allergy and asthma. Protein kinases have a highly conserved ATP binding site, thus making challenging the des
Autor:
Mark L. Wolfe, Jacob Bode, H. David Fischer, Merrill S. Babcock, W. Rodney Mathews, Gurnam S. Gill, Robert L. Garlick, Eric T. Baldwin, Shenping Liu, Jeanne S. Chang, Bruce N. Rogers, Brandon J. Margolis, Eric T. Lund, Vince Groppi
Publikováno v:
Protein Expression and Purification. 79:102-110
Nicotinic acetylcholine receptors (nAChRs) form ligand-gated ion channels that mediate fast signal transmission at synapses. These receptors are members of a large family of pentameric ion channels that are of active medical interest. An expression s
Autor:
Jeffrey B. Doyon, Carol A. Fierke, Chu-Young Kim, Teaster Baird, Ahamindra Jain, Jeanne S. Chang, David W. Christianson
Publikováno v:
Journal of the American Chemical Society. 122:12125-12134
Carbonic anhydrase II (CAII) is a zinc metalloenzyme that catalyzes the hydration of CO2 to yield bicarbonate and a proton. N-(4-Sulfamylbenzoyl)benzylamine (SBB) is a tight-binding inhibitor of hu...