Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Jeanne M. Shaffer"'
Autor:
Jeanne M. Shaffer, Christina M. Marra, W C Van Voorhis, Arturo Centurion-Lara, Christa Castro, Sheila A. Lukehart
Publikováno v:
Scopus-Elsevier
Syphilis is diagnosed by serologic testing or by identification of the causative agent, Treponema pallidum. The bacterium has historically been detected in clinical specimens by dark-field microscopy, immunostaining with polyclonal or monoclonal anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37e7204e01b0d01cf5c7918c4c3f5efe
https://doi.org/10.1128/jcm.35.6.1348-1352.1997
https://doi.org/10.1128/jcm.35.6.1348-1352.1997
Autor:
Lynette R. Demeo, Sheila A. Lukehart, Marinella Cummings, Christa Castro, Jeanne M. Shaffer, William M. McCormack, Barry L. Smith, Christina M. Marra
Publikováno v:
Sexually Transmitted Diseases. 23:366-369
Background The clinical diagnosis of primary and secondary syphilis can be difficult because of the wide variability of lesions. The available laboratory tests (dark-field microscopy and direct fluorescent antibody) require specialized microscopes an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eeb98811a5d638ac196be5f3070c332c
https://doi.org/10.1097/00007435-199609000-00004
https://doi.org/10.1097/00007435-199609000-00004
Publikováno v:
Journal of Infectious Diseases. 167:1100-1105
Although reactivity in nontreponemal tests develops in patients with untreated syphilis, no immunologic function has been ascribed to these antibodies. This study demonstrates that rabbit antibodies induced by immunization with VDRL antigen and VDRL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec79f175aa3ac0ab4356477afd9a62ac
https://doi.org/10.1093/infdis/167.5.1100
https://doi.org/10.1093/infdis/167.5.1100
Publikováno v:
Infection and Immunity. 61:781-784
Rabbit antisera to Leptospira interrogans, Borrelia hermsii, and Treponema phagedenis biotype Reiter, reactive to shared spirochetal antigens, failed to enhance phagocytosis of Treponema pallidum by macrophages, while immunoglobulin G to Treponema pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2497f6e43f49363799adb1b7fb4a463f
https://doi.org/10.1128/iai.61.2.781-784.1993
https://doi.org/10.1128/iai.61.2.781-784.1993
Autor:
Wesley C. Van Voorhis, Caroline E. Stebeck, Jeanne M. Shaffer, Thomas W. Arroll, Sheila A. Lukehart
Publikováno v:
FEMS microbiology letters. 154(2)
To identify potential opsonic targets of Treponema pallidum subsp. pallidum, a treponemal genomic expression library was constructed and differentially screened with opsonic and non-opsonic T. pallidum antisera. This method identified an immunoreacti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b744f78a45e829c677889d38795fc4d4
https://pubmed.ncbi.nlm.nih.gov/9311129
https://pubmed.ncbi.nlm.nih.gov/9311129
Autor:
Christa Castro, Jeanne M. Shaffer, Thomas W. Arroll, Arturo Centurion-Lara, R Castillo, Sheila A. Lukehart, W C Van Voorhis
Publikováno v:
Scopus-Elsevier
The 15-kDa lipoprotein of Treponema pallidum is a major immunogen during natural syphilis infection in humans and experimental infection in other hosts. The humoral and cellular immune responses to this molecule appear late in infection as resistance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cbd43ea68934d632bed042591109fa8
https://europepmc.org/articles/PMC175151/
https://europepmc.org/articles/PMC175151/
Publikováno v:
FEMS immunology and medical microbiology. 6(4)
Serum pools were collected from rabbits bled at various times after intra-testicular infection with Treponema pallidum ssp. pallidum. These were tested for their ability to opsonize T. pallidum and promote killing of the organisms by macrophages. Com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ffb6139c1f35a923d59a6bb2a58900b
https://pubmed.ncbi.nlm.nih.gov/8499892
https://pubmed.ncbi.nlm.nih.gov/8499892
Publikováno v:
The Journal of infectious diseases. 166(6)
While untreated syphilis infection is characterized by spontaneous resolution of early lesions, a few organisms evade the host immune response and persist for many years. Macrophages are generally recognized as the effector cell responsible for bacte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99fe61a1a3856e0e6a37061e4d8b8436
https://pubmed.ncbi.nlm.nih.gov/1431264
https://pubmed.ncbi.nlm.nih.gov/1431264