Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Jeanne M. Manalo"'
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Raising reactive oxygen species (ROS) levels in cancer cells to cause macromolecular damage and cell death is a promising anticancer treatment strategy. Observations that electromagnetic fields (EMF) elevate intracellular ROS and cause cance
Externí odkaz:
https://doaj.org/article/1eea8afbc7594db7b7c3e6e92a0e0004
Autor:
Qingfen Qiang, Jeanne M Manalo, Hong Sun, Yujin Zhang, Anren Song, Alexander Q Wen, Y Edward Wen, Changhan Chen, Hong Liu, Ying Cui, Travis Nemkov, Julie A Reisz, George Edwards Iii, Fred A Perreira, Rodney E Kellems, Claudio Soto, Angelo D'Alessandro, Yang Xia
Publikováno v:
PLoS Biology, Vol 19, Iss 6, p e3001239 (2021)
Hypoxia drives aging and promotes age-related cognition and hearing functional decline. Despite the role of erythrocytes in oxygen (O2) transport, their role in the onset of aging and age-related cognitive decline and hearing loss (HL) remains undete
Externí odkaz:
https://doaj.org/article/80ecf5a3e4c349f8bbbed62e4f09daef
Autor:
Teng-Wei Huang, Amrita A. Iyer, Melissa M. McGovern, Jeanne M. Manalo, Kevin K. Ohlemiller, Navish A. Bosquez Huerta, Heinrich Schrewe, Benjamin Deneen, Junsung Woo, Andrew K. Groves, Fredrick A. Pereira
Publikováno v:
J Neurosci
The Journal of Neuroscience
The Journal of Neuroscience
Mediator protein complex subunit 12 (Med12) is a core component of the basal transcriptional apparatus and plays a critical role in the development of many tissues. Mutations in Med12 are associated with X-linked intellectual disability syndromes and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d00e34f75e25fc41192fee652cc170cf
https://doi.org/10.1523/jneurosci.0070-21.2021
https://doi.org/10.1523/jneurosci.0070-21.2021
Autor:
Hong Sun, Jeanne M. Manalo, Dalian Ding, John Hicks, Richard Salvi, Fred A. Pereira, Rodney E. Kellems, Yang Xia, Hong Liu
Publikováno v:
The FASEB Journal. 34:15771-15787
Over 466 million people worldwide are diagnosed with hearing loss (HL). About 90% of HL cases are sensorineural HL (SNHL) with treatments limited to hearing aids and cochlear implants with no FDA-approved drugs. Intriguingly, ADA-deficient patients h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f260fd4e2d45498699022520d31c7de2
https://doi.org/10.1096/fj.202000939r
https://doi.org/10.1096/fj.202000939r
Publikováno v:
Blood Advances. 3:1347-1355
Sickle cell disease (SCD) is an autosomal-recessive hemolytic disorder with high morbidity and mortality. The pathophysiology of SCD is characterized by the polymerization of deoxygenated intracellular sickle hemoglobin, which causes the sickling of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1ae941a599a8bcd224ac5078eee8011
https://doi.org/10.1182/bloodadvances.2018030619
https://doi.org/10.1182/bloodadvances.2018030619
Autor:
Rodney E. Kellems, Jeanne M. Manalo, Holger K. Eltzschig, Angelo D'Alessandro, Kirk C. Hansen, Robert C. Roach, Yang Xia, Anren Song, Hong Liu, Michael R. Blackburn, Kaiqi Sun
Publikováno v:
Journal of Applied Physiology. 123:951-956
Erythrocytes are vital to human adaptation under hypoxic conditions because of their abundance in number and irreplaceable function of delivering oxygen (O2). However, although multiple large-scale altitude studies investigating the overall coordinat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::608189d85d4b9650d0225c2a78db6f8d
https://doi.org/10.1152/japplphysiol.00155.2017
https://doi.org/10.1152/japplphysiol.00155.2017
Autor:
Yang Xia, Zhaoyang Zhao, Wa Xian, Frank McKeon, Morayo G. Adebiyi, Rodney E. Kellems, Seung Hee Yoo, Yue Hong, Jeanne M. Manalo, Leng Han, Youqiong Ye, Rachel Culp-Hill, Cheng Chi Lee, Angelo D’ Alessandro
The circadian clock is important for cellular and organ function. However, its function in sickle cell disease (SCD), a life-threatening hemolytic disorder, remains unknown. Here, we performed an unbiased microarray screen, which revealed significant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c759c7e34327e61fba004a69eb4269c2
https://europepmc.org/articles/PMC6988849/
https://europepmc.org/articles/PMC6988849/
Autor:
Jeanne M. Manalo, Benjamin Deneen, Hyun Kyoung Lee, Chad J. Creighton, Yoshihiro Kawasaki, Stacey M. Glasgow, Carrie A. Mohila, Fengju Chen, Lesley S. Chaboub, Tetsu Akiyama, Chay T. Kuo
Publikováno v:
The Journal of Neuroscience. 36:11904-11917
Lineage development is a stepwise process, governed by stage-specific regulatory factors and associated markers. Astrocytes are one of the principle cell types in the CNS and the stages associated with their development remain very poorly defined. To
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6864f3d4b08dc4c36edf8558a74d722
https://doi.org/10.1523/jneurosci.1658-16.2016
https://doi.org/10.1523/jneurosci.1658-16.2016
Autor:
Holger K. Eltzschig, Hong Liu, Tingting Weng, Yang Xia, Junsuk Ko, Yuan Edward Wen, Anren Song, Rodney E. Kellems, Michael R. Blackburn, Jeanne M. Manalo, Harinder S. Juneja, Morayo G. Adebiyi, Alexander Q. Wen, Modupe Idowu, Rong Rong Liu
Publikováno v:
Blood advances. 2(15)
Although excessive plasma adenosine is detrimental in sickle cell disease (SCD), the molecular mechanism underlying elevated circulating adenosine remains unclear. Here we report that the activity of soluble CD73, an ectonucleotidase producing extrac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a9c4f8ecf894cef1790141e190284b2
https://pubmed.ncbi.nlm.nih.gov/30097462
https://pubmed.ncbi.nlm.nih.gov/30097462
Autor:
Ye Youqiong, Yang Xia, Angelo D'Alessandro, Cheng Chi Lee, Jeanne M. Manalo, Morayo G. Adebiyi, Zhaoyang Zhao, Leng Han, Wa Xian, Frank McKeon, Rodney E. Kellems, Seung Hee Yoo, Rachel Culp-Hill
Publikováno v:
Blood. 132:3644-3644
Sickle-cell disase (SCD) is a life-threatening hemolytic genetic disorder. Chronic hemolysis and elevated inflammation that underlie SCD pathophysiology is difficult to treat in the clinic due to an unclear mechanism. The role of the circadian clock
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee6b70822afc4b9faeee04c266f52074
https://doi.org/10.1182/blood-2018-99-111211
https://doi.org/10.1182/blood-2018-99-111211