Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Jeanne M. Fahey"'
Autor:
Jeanne M. Fahey, Renganayaki Krishna Pandurengan, David R. Fogelman, James C. Yao, Milind Javle, Ella Sorani, Abi Vainstein-Haras, Steven M. Townson, Debora A. Ledesma, Osnat Kashtan, Mei Jiang, Yosi Gozlan, Michael J. Overman, Shubham Pant, Rachna T. Shroff, Ignacio I. Wistuba, Edwin R. Parra, Carmelia Maria Noia Barreto, Gauri R. Varadhachary, Tzipora M. Lustig, Robert A. Wolff, Swati Gite, Luisa M. Solis
Publikováno v:
Cancer Research. 80:CT204-CT204
Background: We recently conducted a clinical trial assessing Pembrolizumab (P) and BL-8040 (BL) in patients with pancreatic cancer. We prospectively collected serial biopsies to help understand the impact of this treatment on the tumor microenvironme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26557040b159c361b326348ff0d84cc1
https://doi.org/10.1158/1538-7445.am2020-ct204
https://doi.org/10.1158/1538-7445.am2020-ct204
Autor:
Gary A. Pritchard, David J. Greenblatt, Jeffrey M. Grassi, Richard I. Shader, Jeanne M. Fahey, John Pratt
Publikováno v:
Journal of Psychopharmacology. 13:211-218
Previous work in our laboratory has demonstrated region-specic effects for chronic alprazolam on binding and function at the GABAA receptor. The present study evaluated regional changes in mRNA expression of several subunits of the GABAA receptor fol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::971b55fefc23c0215f57bf2320e3d9af
https://doi.org/10.1177/026988119901300301
https://doi.org/10.1177/026988119901300301
Publikováno v:
Brain Research. 669:183-188
Pregnenolone sulfate (PS) has been reported to selectively augment glutamate-induced depolarizations mediated by the NMDA subtype of the glutamate receptor. The present study examines the ability of this neuroactive steroid to potentiate NMDA-mediate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb48da79a866a40a3c165f6321b84174
https://doi.org/10.1016/0006-8993(94)01223-5
https://doi.org/10.1016/0006-8993(94)01223-5
Publikováno v:
Neuroscience Letters. 161:109-112
Release of endogenous polyamines may contribute to neuronal loss in ischemia and related conditions. Primary cortical neurons were exposed to spermine and spermidine and subsequently assayed for [3H]ouabain binding to quantify neuronal loss. Neuronal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d33626936278e0fc7d59a33cc9341189
https://doi.org/10.1016/0304-3940(93)90152-b
https://doi.org/10.1016/0304-3940(93)90152-b
Autor:
Connie Sanchez, Thomas I. F. H. Cremers, Neil J. Anderson, Vanessa Vogel, Jeanne M. Fahey, Stine Rasmussen, Biarke Ebert
Publikováno v:
Pharmacology, Biochemistry and Behavior, 90(1), 113-122. Elsevier
Gaboxadol, a selective extra synaptic GABA(A) receptor agonist, has been in clinical development for the treatment of insomnia. Development of tolerance to therapeutic effects (e.g. hypnotic and anticonvulsant and sedative) and withdrawal symptoms (e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b89b523d9574141c52ef0229db7e093c
https://pubmed.ncbi.nlm.nih.gov/18304623
https://pubmed.ncbi.nlm.nih.gov/18304623
Publikováno v:
The Journal of pharmacy and pharmacology. 59(7)
Extended treatment with human immunodeficiency virus (HIV) protease inhibitors (HPIs) is standard in HIV/AIDS therapy. While these drugs have helped decrease the overall incidence of AIDS defining illnesses, the relative prevalence of HIV/AIDS dement
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c455110fbb90d657a6809e7e2cf42bd
https://pubmed.ncbi.nlm.nih.gov/17637189
https://pubmed.ncbi.nlm.nih.gov/17637189
Publikováno v:
Pharmacology, biochemistry, and behavior. 83(1)
Zolpidem is chemically unrelated to classical benzodiazepines but has demonstrated relatively high affinity binding to the alpha(1) GABA(A) receptor. To assess pharmacodynamic and neurochemical effects of zolpidem, open-field behavior, pentylenetetra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff5cca46cd97f570f0843bc1986e721b
https://pubmed.ncbi.nlm.nih.gov/16439007
https://pubmed.ncbi.nlm.nih.gov/16439007
Autor:
Gary A. Pritchard, John Pratt, Jyoti M. Reddi, David J. Greenblatt, Jeanne M. Fahey, Richard I. Shader, Jeffrey M. Grassi
Publikováno v:
Brain research. 1118(1)
To assess benzodiazepine tolerance in aged animals, lorazepam or vehicle was administered chronically to male Crl: CD-1(ICR)BR mice. Pharmacodynamic and neurochemical endpoints were examined on days 1 and 14 of drug administration. There was no age-r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68c1ff16d68c76fb54716744b94f73a4
https://pubmed.ncbi.nlm.nih.gov/16989785
https://pubmed.ncbi.nlm.nih.gov/16989785
Publikováno v:
Annals of the New York Academy of Sciences. 993
Previously we reported delayed cell death, defined by clear-cut cell loss 60 days after a nitrite-induced hypoxic episode. The loss of cells was not apparent two weeks after the treatment, although some changes in cellular appearance were observed at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ddf61719580e64225eff1950e713d06
https://pubmed.ncbi.nlm.nih.gov/12853312
https://pubmed.ncbi.nlm.nih.gov/12853312
Autor:
David J. Greenblatt, Gary A. Pritchard, Jeanne M. Fahey, John Pratt, Jeffrey M. Grassi, Richard I. Shader
Publikováno v:
Pharmacology, biochemistry, and behavior. 69(1-2)
To assess pharmacodynamic and neurochemical aspects of tolerance, lorazepam (2 mg/kg/day), or vehicle was administered chronically to male Crl: CD-1(ICR)BR mice via implantable osmotic pump. Open-field behavior, benzodiazepine receptor binding in vit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13d2c6b02284de3c5b6fadc9b7d2cf46
https://pubmed.ncbi.nlm.nih.gov/11420062
https://pubmed.ncbi.nlm.nih.gov/11420062