Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Jeanne M. Connolly"'
Autor:
Harry Ischiropoulos, Robert J. Levy, Ivan S. Alferiev, Jeanne M. Connolly, Abigail J. Christian
Publikováno v:
Journal of Biomedical Materials Research Part A. 103:2441-2448
Bioprosthetic heart valves (BHV) fabricated from glutaraldehyde pretreated heterograft materials, porcine aortic valves or bovine pericardium (BP), are widely used in cardiac surgery. BHV progressively fail in clinical use due to structural degenerat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb0f763a4e6aff2fb0513543ca371a3d
https://doi.org/10.1002/jbm.a.35380
https://doi.org/10.1002/jbm.a.35380
Autor:
Ivan S. Alferiev, Giovanni Ferrari, Robert J. Levy, Harry Ischiropoulos, Abigail J. Christian, Hongqiao Lin, Stanley L. Hazen, Jeanne M. Connolly
Publikováno v:
Biomaterials. 35:2097-2102
The clinical use of bioprosthetic heart valves (BHV) is limited due to device failure caused by structural degeneration of BHV leaflets. In this study we investigated the hypothesis that oxidative stress contributes to this process. Fifteen clinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c483338ae987425a204a890e0486881
https://doi.org/10.1016/j.biomaterials.2013.11.045
https://doi.org/10.1016/j.biomaterials.2013.11.045
Autor:
Howard S. Kruth, Frederick J. Schoen, Robert C. Gorman, Ivan S. Alferiev, Richard W. Bianco, Jeanne M. Connolly, Robert J. Levy, Joseph H. Gorman, Paul E. Ashworth, Marina Bakay, Jaishankar K. Kutty
Publikováno v:
The Annals of Thoracic Surgery. 92:858-865
Background One of the most important factors responsible for the calcific failure of bioprosthetic heart valves is glutaraldehyde crosslinking. Ethanol (EtOH) incubation after glutaraldehyde crosslinking has previously been reported to confer antical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9f96d7867066d8999eec01e694da1f3
https://doi.org/10.1016/j.athoracsur.2011.04.104
https://doi.org/10.1016/j.athoracsur.2011.04.104
Autor:
Xuemei Zhang, Jeanne M. Connolly, Kartik Balachandran, Robert J. Levy, Ajit P. Yoganathan, Marina Bakay
Publikováno v:
The Annals of Thoracic Surgery. 92:147-153
Increased serotonin (5-hydroxytryptamine [5HT]) receptor (5HTR) signaling has been associated with cardiac valvulopathy. Prior cell culture studies of 5HTR signaling in heart valve interstitial cells have provided mechanistic insights concerning only
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0699d97fd8480cb8c83cc7c1fd368da
https://doi.org/10.1016/j.athoracsur.2011.03.084
https://doi.org/10.1016/j.athoracsur.2011.03.084
Autor:
Jason Arndt, Jeanne M. Connolly, Caryn A. Reynolds, Robert J. Levy, Mark A. Oyama, Gretchen E. Singletary
Publikováno v:
Journal of Veterinary Internal Medicine. 23:1208-1213
Background: Increased serotonin (5HT) signaling has been implicated in valvular disease of humans and animals, including canine degenerative mitral valve disease (DMVD). High circulating 5HT concentration is a potential source of increased signaling,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd789c6a69d1394307f5ff1000c288a5
https://doi.org/10.1111/j.1939-1676.2009.0378.x
https://doi.org/10.1111/j.1939-1676.2009.0378.x
Autor:
Robert J. Levy, Joseph H. Gorman, James Fulmer, Jeanne M. Connolly, Robert C. Gorman, Marina Bakay, Mark A. Oyama
Publikováno v:
The American Journal of Pathology. 175:988-997
Serotonin (5HT) receptor signaling and 5HT-related agents, such as the anorexogen fenfluramine (Fen), have been associated with heart valve disease. We investigated the hypothesis that Fen may disrupt mitral valve interstitial cell (MVIC) homeostasis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::132281aeec35b779f74005c80780086e
https://doi.org/10.2353/ajpath.2009.081101
https://doi.org/10.2353/ajpath.2009.081101
Autor:
Robert C. Gorman, H. Scott Rapoport, Robert J. Levy, Jeanne M. Connolly, Joseph H. Gorman, Navneet Narula, Emile R. Mohler, Jocelyn N. Clark-Greuel, Elizabeth Sorichillo
Publikováno v:
The Annals of Thoracic Surgery. 83:946-953
Background Aortic valve stenosis is the most frequent indication for valve replacement surgery, and is commonly associated with pathologic calcification. Previous investigations by our group have shown a strong association of transforming growth fact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f129eabf89ca670477a42c47b59586a
https://doi.org/10.1016/j.athoracsur.2006.10.026
https://doi.org/10.1016/j.athoracsur.2006.10.026
Autor:
Ning Dai, H. Scott Rapoport, Robert C. Gorman, Ivan S. Alferiev, Robert J. Levy, Jeanne M. Connolly, Joseph H. Gorman, James Fulmer, Brandon H. Murti
Publikováno v:
Biomaterials. 28:690-699
Heart valve replacements fabricated from glutaraldehyde (Glut)-crosslinked heterograft materials, porcine aortic valves or bovine pericardium, have been widely used in cardiac surgery to treat heart valve disease. However, these bioprosthetic heart v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3521cea1db3089329883523d8bbb99e
https://doi.org/10.1016/j.biomaterials.2006.09.029
https://doi.org/10.1016/j.biomaterials.2006.09.029
Autor:
Stanley J. Stachelek, Ivan S. Alferiev, Lubica Rauova, Robert J. Levy, Allis Ottey, Jeanne M. Connolly
Publikováno v:
Biomacromolecules. 7:317-322
Previous research from our group has demonstrated that bromoalkylation of polyurethane elastomers via base mediated activation of the urethane-hard segment nitrogen groups can be used to either attach bisphosphonate groups to confer calcification res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05d74eb96fbd8926735ef35a807f6180
https://doi.org/10.1021/bm0506694
https://doi.org/10.1021/bm0506694
Autor:
Ivan S. Alferiev, Robert L. Wilensky, Stanley J. Stachelek, Robert J. Levy, Jeanne M. Connolly, Ilia Fishbein
Publikováno v:
Journal of Controlled Release. 109:37-48
Gene therapy holds great promise for treating both genetic and acquired disorders. However, progress toward effective human gene therapy has been thwarted by a number of problems including vector toxicity, poor targeting of diseased tissues, and host
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34649fe29b23a19d8982c9d1f01ec8b4
https://doi.org/10.1016/j.jconrel.2005.09.031
https://doi.org/10.1016/j.jconrel.2005.09.031