Zobrazeno 1 - 10
of 208
pro vyhledávání: '"Jeanne M, Nerbonne"'
Publikováno v:
eLife, Vol 11 (2022)
The resurgent component of the voltage-gated sodium current (INaR) is a depolarizing conductance, revealed on membrane hyperpolarizations following brief depolarizing voltage steps, which has been shown to contribute to regulating the firing properti
Externí odkaz:
https://doaj.org/article/2e8784b6ede74b6796c68e92f3bd9578
Autor:
Wandi Zhu, Wei Wang, Paweorn Angsutararux, Rebecca L. Mellor, Lori L. Isom, Jeanne M. Nerbonne, Jonathan R. Silva
Publikováno v:
JCI Insight, Vol 6, Iss 15 (2021)
Native myocardial voltage-gated sodium (NaV) channels function in macromolecular complexes comprising a pore-forming (α) subunit and multiple accessory proteins. Here, we investigated the impact of accessory NaVβ1 and NaVβ3 subunits on the functio
Externí odkaz:
https://doaj.org/article/3a1cd7dc535f4598ae819c3d1643d27f
Autor:
Kathryn E Mangold, Wei Wang, Eric K Johnson, Druv Bhagavan, Jonathan D Moreno, Jeanne M Nerbonne, Jonathan R Silva
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 8, p e1008932 (2021)
Markov models of ion channel dynamics have evolved as experimental advances have improved our understanding of channel function. Past studies have examined limited sets of various topologies for Markov models of channel dynamics. We present a systema
Externí odkaz:
https://doaj.org/article/3aacf089bcfd4490b3426bc8206f6128
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Abstract The four chambers of the human heart play distinct roles in the maintenance of normal cardiac function, and are differentially affected by inherited/acquired cardiovascular disease. To probe the molecular determinants of these functional dif
Externí odkaz:
https://doaj.org/article/677aef6ddd89489292f6b166481d1072
Autor:
Joseph L. Ransdell, Edward Dranoff, Brandon Lau, Wan-Lin Lo, David L. Donermeyer, Paul M. Allen, Jeanne M. Nerbonne
Publikováno v:
Cell Reports, Vol 19, Iss 3, Pp 532-544 (2017)
Summary: The resurgent component of voltage-gated Na+ (Nav) currents, INaR, has been suggested to provide the depolarizing drive for high-frequency firing and to be generated by voltage-dependent Nav channel block (at depolarized potentials) and unbl
Externí odkaz:
https://doaj.org/article/e856e8bc6d5743638b7f92c3b58afa42
Autor:
Paweorn Angsutararux, Amal K. Dutta, Martina Marras, Carlota Abella, Rebecca L. Mellor, Jingyi Shi, Jeanne M. Nerbonne, Jonathan R. Silva
Publikováno v:
Journal of General Physiology. 155
Voltage-gated sodium (NaV) channels are responsible for the initiation and propagation of action potentials. In the heart, the predominant NaV1.5 α subunit is composed of four homologous repeats (I–IV) and forms a macromolecular complex with multi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8702c5ebcba63f5fc9446d38ad34238e
https://doi.org/10.1085/jgp.202213300
https://doi.org/10.1085/jgp.202213300
Autor:
Tracey O. Hermanstyne, Nien-Du Yang, Daniel Granados-Fuentes, Xiaofan Li, Rebecca L. Mellor, Timothy Jegla, Erik D. Herzog, Jeanne M. Nerbonne
Considerable evidence suggests that day-night rhythms in the functional expression of subthreshold potassium (K+) channels regulate daily oscillations in the rates of spontaneous action potential firing of neurons in the suprachiasmatic nucleus (SCN)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::656ff9144c767f2f52ec43a205a92a24
https://doi.org/10.1101/2023.01.30.526323
https://doi.org/10.1101/2023.01.30.526323
Publikováno v:
JACC: Basic to Translational Science, Vol 1, Iss 6, Pp 554-556 (2016)
Externí odkaz:
https://doaj.org/article/ec0e4ff18695497b8376ac1f595c8950
Autor:
Nien-Du Yang, Richard Kanyo, Lu Zhao, Jingru Li, Po Wei Kang, Alex Kelly Dou, Kelli McFarland White, Jingyi Shi, Jeanne M. Nerbonne, Harley T. Kurata, Jianmin Cui
Publikováno v:
Science Advances. 8
KCNQ2 and KCNQ3 form the M-channels that are important in regulating neuronal excitability. Inherited mutations that alter voltage-dependent gating of M-channels are associated with neonatal epilepsy. In the homolog KCNQ1 channel, two steps of voltag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75bb5eaa6e6b78b823fc19b1cf85d4c6
https://doi.org/10.1126/sciadv.abo3625
https://doi.org/10.1126/sciadv.abo3625
Autor:
Marie E. Robert, Stuart G. Campbell, Allison L. Brill, Parker C. Wilson, Arnaud Marlier, Gilbert W. Moeckel, Tom T. Fischer, Hee Jung Chung, Jeanne M. Nerbonne, Barbara E. Ehrlich, Eric K. Johnson, Lorenzo R. Sewanan, Jennifer M. Walters, Lloyd G. Cantley
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific Reports
Scientific Reports
Polycystin 2 (PC2 or TRPP1, formerly TRPP2) is a calcium-permeant Transient Receptor Potential (TRP) cation channel expressed primarily on the endoplasmic reticulum (ER) membrane and primary cilia of all cell and tissue types. Despite its ubiquitous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b747ce23c14f22338c67c7d8c189d82c
http://link.springer.com/article/10.1038/s41598-019-57286-x
http://link.springer.com/article/10.1038/s41598-019-57286-x