Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Jeanne Grace Flandez"'
Autor:
Fei Han, Shouchun Liu, Stephen James Moore, Jennifer Richardson, Jason Gee, Annie Yang, Olga Vasiljeva, Margaret Nguyen, Luc R. Desnoyers, Kenneth R. Wong, Kate Markham, Elizabeth Menendez, Kathy Kamath, Tony W. Liang, Jeanne Grace Flandez, Daniel R. Hostetter, James W. West, Chihunt Wong, Paul H. Bessette, Henry B. Lowman, Michael Krimm, Patrick S. Daugherty, Jason Gary Sagert
Publikováno v:
Science Translational Medicine. 5
Target-mediated toxicity constitutes a major limitation for the development of therapeutic antibodies. To redirect the activity of antibodies recognizing widely distributed targets to the site of disease, we have applied a prodrug strategy to create
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3db22ff4ba0636787e1f4574421baf32
https://doi.org/10.1126/scitranslmed.3006682
https://doi.org/10.1126/scitranslmed.3006682
Autor:
Luc Desnoyers, Yuanhui Huang, Andrew Jang, Elizabeth Menendez, Jason Gary Sagert, Shouchun Liu, Eric Brecht, Olga Vasiljeva, Margaret Nguyen, Nicole Lapuyade, James W. West, Michael Krimm, Annie Yang Weaver, Jeanne Grace Flandez, Stephen R. Moore, Judi Ford, W. Michael Kavanaugh, Linnea Diep, Tereza Sputova, Jonathan A. Terrett, Shweta Singh, Amy DuPage, Jennifer Richardson
Publikováno v:
Molecular Cancer Therapeutics. 14:C165-C165
Antibody drug conjugates (ADCs) have shown their greatest clinical utility when targeting antigens expressed at very high levels on cancer cells that have coincidentally lower expression in normal tissues. This is exemplified by the approvals of tras
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9dfa74c2d7feb91893fa08e253ae6595
https://doi.org/10.1158/1535-7163.targ-15-c165
https://doi.org/10.1158/1535-7163.targ-15-c165