Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Jeanne E. Wilson"'
Autor:
Thomas G. Consler, David J.T. Porter, Frank Preugschat, Mary H. Hanlon, Derril H. Willard, Jeanne E. Wilson, Steven A. Short
Publikováno v:
Journal of Biological Chemistry. 273:18906-18914
Hepatitis C virus (HCV) helicase catalyzes the ATP-dependent strand separation of duplex RNA and DNA containing a 3' single-stranded tail. Equilibrium and velocity sedimentation centrifugation experiments demonstrated that the enzyme was monomeric in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::064272f9d19478176ca6a2b87ee7f17d
https://doi.org/10.1074/jbc.273.30.18906
https://doi.org/10.1074/jbc.273.30.18906
Autor:
Phillip A. Furman, Jeanne E. Wilson, Ann Aulabaugh, J E Reardon, Casey D. Morrow, Brent Caligan, Sandra A. Jablonski, Sylvia A. McPherson, John K. Wakefield
Publikováno v:
Journal of Biological Chemistry. 271:13656-13662
Mutations were made in recombinant human immunodeficiency virus type-1 reverse transcriptase (RT) by substituting methionine 184 with alanine (M184A) or valine (M184V), and steady-state and pre-steady-state kinetic constants were determined. The Km v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::536ebeb195336aa928a00b632c70f50d
https://doi.org/10.1074/jbc.271.23.13656
https://doi.org/10.1074/jbc.271.23.13656
Autor:
Nanine A. VanDraanen, George Andrew Freeman, Ann Aulabaugh, Wayne H. Miller, George R. Painter, Lawrence R. Boone, Boyd Frank Leslie, Susan Mary Daluge, Jeanne E. Wilson, Michelle G. Davis
Publikováno v:
Antiviral Research. 30:133-145
DNA polymerase activity was assayed in hepatitis B virus (HBV) and core particles isolated from chronic producer lines. The particle-associated DNA polymerase activity, which was found to be limited to incorporation of only a few nucleotides, was inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84104b27347efdf8cf457bf7c6910c07
https://doi.org/10.1016/0166-3542(96)00938-2
https://doi.org/10.1016/0166-3542(96)00938-2
Autor:
Jeanne E. Wilson, J. Louise Martin, Paul H. Ray, Lois L. Wright, George R. Painter, Sarah E. Haire, Phillip A. Furman
Publikováno v:
Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology. 11:20-30
Recombinant wild type (wt) and T215Y HIV-1 reverse transcriptase (RT) were isolated using three methods designated A, B, and C. The three samples of wt RT were kinetically indistinguishable with respect to dTTP turnover on poly(rA) · p(dT)10. Howeve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::710979e1853ab50ef1ab75c23c4ce89f
https://doi.org/10.1097/00042560-199601010-00003
https://doi.org/10.1097/00042560-199601010-00003
Publikováno v:
Antiviral Chemistry and Chemotherapy. 6:345-355
This review concerns the effect of stereoisomerism on the selective activity of anti-HIV and anti-HBV nucleoside analogues.The synthesis of a number of nucleoside analogues with anti-HIV and anti-HBV activity yields mixtures of 1-β-D and 1-β-L ster
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e31d49c057b75a9e69a60df5b93a1bab
https://doi.org/10.1177/095632029500600601
https://doi.org/10.1177/095632029500600601
Publikováno v:
Journal of Biological Chemistry. 268:2565-2570
Site-directed mutagenesis has been used to assess the importance of lysine 263 in substrate binding of human immunodeficiency virus-1 (HIV-1) reverse transcriptase. Previous studies have indicated that lysine 263 functions in the binding of 2'-deoxyn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b61cf5bd023f7075ca1a905d762aa07e
https://doi.org/10.1016/s0021-9258(18)53811-4
https://doi.org/10.1016/s0021-9258(18)53811-4
Autor:
Jeanne E. Wilson, K Borroto-Esoda, D C Liotta, G R Painter, P A Furman, J L Martin, Sam Hopkins
Publikováno v:
Antimicrobial agents and chemotherapy. 37(8)
The (-) enantiomer of cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolane-5-yl]cytosine is a potent inhibitor of human immunodeficiency virus type 1 in vitro. The 5'-triphosphates of the (-) and (+) enantiomers equally inhibited the production of full-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4cf473289e7b9d80976cdf683a98995
https://pubmed.ncbi.nlm.nih.gov/7692813
https://pubmed.ncbi.nlm.nih.gov/7692813
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 90(13)
A molecular clone containing the wild-type reverse transcriptase (RT) coding region of human immunodeficiency virus type 1 (HIV-1) was constructed, and site-directed mutagenesis was used to introduce mutations--Leu74-->Val (L74V), T215Y, and the comb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a3cb4c969a6ffd471334ed6d273c155
https://pubmed.ncbi.nlm.nih.gov/7687061
https://pubmed.ncbi.nlm.nih.gov/7687061
Substrate inhibition was observed with the heterodimeric (p66/p51) and the homodimeric (p66/p66, p51/p51) forms of human immunodeficiency virus type 1 reverse transcriptase (RNA-dependent DNA polymerase, EC 2.7.7.49). An apparent Ki value of 195 +/-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20d58917f927e7f5f7dab8fd90579a1c
https://europepmc.org/articles/PMC52012/
https://europepmc.org/articles/PMC52012/
