Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Jeanne C Latourelle"'
Publikováno v:
Frontiers in Aging Neuroscience, Vol 8 (2016)
Objective. The goal of this study was to compare the microRNA (miRNA) profile of Parkinson’s disease (PD) frontal cortex with normal control brain, allowing for the identification of PD specific signatures as well as study the disease-related pheno
Externí odkaz:
https://doaj.org/article/9790b20a89b54dbabd8eb63af97c32b6
Autor:
Adam Labadorf, Andrew G Hoss, Valentina Lagomarsino, Jeanne C Latourelle, Tiffany C Hadzi, Joli Bregu, Marcy E MacDonald, James F Gusella, Jiang-Fan Chen, Schahram Akbarian, Zhiping Weng, Richard H Myers
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0160295 (2016)
[This corrects the article DOI: 10.1371/journal.pone.0143563.].
Externí odkaz:
https://doaj.org/article/31e3b7d7a47d45caa417df439d32fe0a
Autor:
Michael W Nagle, Jeanne C Latourelle, Adam Labadorf, Alexandra Dumitriu, Tiffany C Hadzi, Thomas G Beach, Richard H Myers
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0160925 (2016)
Genome-wide association studies (GWAS) have identified the GAK/DGKQ/IDUA region on 4p16.3 among the top three risk loci for Parkinson's disease (PD), but the specific gene and risk mechanism are unclear. Here, we report transcripts containing the 3'
Externí odkaz:
https://doaj.org/article/5f5c12c378974db2a5b11db90119047c
Publikováno v:
Clinical Epidemiology, Vol 2010, Iss default, Pp 153-170 (2010)
Jeanne C Latourelle1,2, Merete Dybdahl3, Anita L Destefano1,4, Richard H Myers1, Timothy L Lash2,31Department of Neurology, Boston University School of Medicine, Boston MA, USA; 2Department of Epidemiology, Boston University School of Public Health,
Externí odkaz:
https://doaj.org/article/a74908bad33d47598231f134c0d5831b
Autor:
Adam Labadorf, Andrew G Hoss, Valentina Lagomarsino, Jeanne C Latourelle, Tiffany C Hadzi, Joli Bregu, Marcy E MacDonald, James F Gusella, Jiang-Fan Chen, Schahram Akbarian, Zhiping Weng, Richard H Myers
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0143563 (2015)
Huntington's Disease (HD) is a devastating neurodegenerative disorder that is caused by an expanded CAG trinucleotide repeat in the Huntingtin (HTT) gene. Transcriptional dysregulation in the human HD brain has been documented but is incompletely und
Externí odkaz:
https://doaj.org/article/47aee1946d1844d683fa9f7652b647e8
Autor:
Andrew G Hoss, Vinay K Kartha, Xianjun Dong, Jeanne C Latourelle, Alexandra Dumitriu, Tiffany C Hadzi, Marcy E Macdonald, James F Gusella, Schahram Akbarian, Jiang-Fan Chen, Zhiping Weng, Richard H Myers
Publikováno v:
PLoS Genetics, Vol 10, Iss 2, p e1004188 (2014)
Transcriptional dysregulation has long been recognized as central to the pathogenesis of Huntington's disease (HD). MicroRNAs (miRNAs) represent a major system of post-transcriptional regulation, by either preventing translational initiation or by ta
Externí odkaz:
https://doaj.org/article/46aedee467964d989dea7f9beed8d201
Autor:
Alexandra Dumitriu, Jeanne C Latourelle, Tiffany C Hadzi, Nathan Pankratz, Dan Garza, John P Miller, Jeffery M Vance, Tatiana Foroud, Thomas G Beach, Richard H Myers
Publikováno v:
PLoS Genetics, Vol 8, Iss 6, p e1002794 (2012)
Parkinson disease (PD) is a complex neurodegenerative disorder with largely unknown genetic mechanisms. While the degeneration of dopaminergic neurons in PD mainly takes place in the substantia nigra pars compacta (SN) region, other brain areas, incl
Externí odkaz:
https://doaj.org/article/7e3dad71dae94e249d34186097257ac3
Autor:
Christina M Lill, Johannes T Roehr, Matthew B McQueen, Fotini K Kavvoura, Sachin Bagade, Brit-Maren M Schjeide, Leif M Schjeide, Esther Meissner, Ute Zauft, Nicole C Allen, Tian Liu, Marcel Schilling, Kari J Anderson, Gary Beecham, Daniela Berg, Joanna M Biernacka, Alexis Brice, Anita L DeStefano, Chuong B Do, Nicholas Eriksson, Stewart A Factor, Matthew J Farrer, Tatiana Foroud, Thomas Gasser, Taye Hamza, John A Hardy, Peter Heutink, Erin M Hill-Burns, Christine Klein, Jeanne C Latourelle, Demetrius M Maraganore, Eden R Martin, Maria Martinez, Richard H Myers, Michael A Nalls, Nathan Pankratz, Haydeh Payami, Wataru Satake, William K Scott, Manu Sharma, Andrew B Singleton, Kari Stefansson, Tatsushi Toda, Joyce Y Tung, Jeffery Vance, Nick W Wood, Cyrus P Zabetian, andMe Genetic Epidemiology of Parkinson's Disease Consortium, International Parkinson's Disease Genomics Consortium, Parkinson's Disease GWAS Consortium, Wellcome Trust Case Control Consortium 2), Peter Young, Rudolph E Tanzi, Muin J Khoury, Frauke Zipp, Hans Lehrach, John P A Ioannidis, Lars Bertram
Publikováno v:
PLoS Genetics, Vol 8, Iss 3, p e1002548 (2012)
More than 800 published genetic association studies have implicated dozens of potential risk loci in Parkinson's disease (PD). To facilitate the interpretation of these findings, we have created a dedicated online resource, PDGene, that comprehensive
Externí odkaz:
https://doaj.org/article/cfc8c07e05884d89b6a183d737c73b81
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e46199 (2012)
The recent Parkinson Disease GWAS Consortium meta-analysis and replication study reports association at several previously confirmed risk loci SNCA, MAPT, GAK/DGKQ, and HLA and identified a novel risk locus at RIT2. To further explore functional cons
Externí odkaz:
https://doaj.org/article/2a22c76f2906497eb594e58057d42705
Autor:
Nathan Pankratz, Alexandra Dumitriu, Kurt N Hetrick, Mei Sun, Jeanne C Latourelle, Jemma B Wilk, Cheryl Halter, Kimberly F Doheny, James F Gusella, William C Nichols, Richard H Myers, Tatiana Foroud, Anita L DeStefano, PSG-PROGENI and GenePD Investigators, Coordinators and Molecular Genetic Laboratories
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e20988 (2011)
Copy number variants (CNVs) are known to cause Mendelian forms of Parkinson disease (PD), most notably in SNCA and PARK2. PARK2 has a recessive mode of inheritance; however, recent evidence demonstrates that a single CNV in PARK2 (but not a single mi
Externí odkaz:
https://doaj.org/article/35b500ab30934e039c31e84cc71c44a4