Zobrazeno 1 - 10
of 163
pro vyhledávání: '"Jeanne A. Stuckey"'
Autor:
Taolin Yuan, Surinder Kumar, Mary E. Skinner, Ryan Victor-Joseph, Majd Abuaita, Jaap Keijer, Jessica Zhang, Thaddeus J. Kunkel, Yanghan Liu, Elyse M. Petrunak, Thomas L. Saunders, Andrew P. Lieberman, Jeanne A. Stuckey, Nouri Neamati, Fathiya Al-Murshedi, Majid Alfadhel, Johannes N. Spelbrink, Richard Rodenburg, Vincent C.J. de Boer, David B. Lombard
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109991- (2024)
Summary: SIRT5 is a sirtuin deacylase that removes negatively charged lysine modifications, in the mitochondrial matrix and elsewhere in the cell. In benign cells and mouse models, under basal conditions, the phenotypes of SIRT5 deficiency are quite
Externí odkaz:
https://doaj.org/article/1b3e08c25bb044469b8c3e5f02f889fd
Autor:
Haibin Zhou, Jianfeng Lu, Krishnapriya Chinnaswamy, Jeanne A. Stuckey, Liu Liu, Donna McEachern, Chao-Yie Yang, Denzil Bernard, Hong Shen, Liangyou Rui, Yi Sun, Shaomeng Wang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Activation of cullin-RING ligases can be inhibited by targeting DCN1, but selective DCN1 inhibitors with in vivo activity are lacking. Here, the authors develop covalent DCN1 inhibitors that selectively and potently inhibit cullin-3 activation and do
Externí odkaz:
https://doaj.org/article/f1b1354b41f3482fb5e78275ffe16f27
Autor:
Thomas J. Wubben, Sraboni Chaudhury, Brennan T. Watch, Jeanne A. Stuckey, Eric Weh, Roshini Fernando, Moloy Goswami, Mercy Pawar, Jason C. Rech, Cagri G. Besirli
Publikováno v:
Pharmaceuticals, Vol 16, Iss 5, p 705 (2023)
Treatment options are lacking to prevent photoreceptor death and subsequent vision loss. Previously, we demonstrated that reprogramming metabolism via the pharmacologic activation of PKM2 is a novel photoreceptor neuroprotective strategy. However, th
Externí odkaz:
https://doaj.org/article/7124d30a36fa4bc784f3b67ee9fb35b2
Autor:
Evelyn M. Covés-Datson, Steven R. King, Maureen Legendre, Michael D. Swanson, Auroni Gupta, Sandra Claes, Jennifer L. Meagher, Arnaud Boonen, Lihong Zhang, Birte Kalveram, Zoe Raglow, Alexander N. Freiberg, Mark Prichard, Jeanne A. Stuckey, Dominique Schols, David M. Markovitz
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Lectins, carbohydrate-binding proteins, have been regarded as potential antiviral agents, as some can bind glycans on viral surface glycoproteins and inactivate their functions. However, clinical development of lectins has been stalled by th
Externí odkaz:
https://doaj.org/article/283392a3b205412094e2427caa1508b6
Autor:
Kavya Ramkumar, Soma Samanta, Anahita Kyani, Suhui Yang, Shuzo Tamura, Elizabeth Ziemke, Jeanne A. Stuckey, Si Li, Krishnapriya Chinnaswamy, Hiroyuki Otake, Bikash Debnath, Vladimir Yarovenko, Judith S. Sebolt-Leopold, Mats Ljungman, Nouri Neamati
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Glutathione S-transferase omega 1 (GSTO1) is an atypical GST isoform overexpressed in several cancers that has been implicated in drug resistance. Here the authors identify a small molecule inhibitor of GSTO1 that effectively inhibits tumor growth in
Externí odkaz:
https://doaj.org/article/7431badb33544578ba6eb5990f3bb58e
Autor:
Sunita Shankar, Sethuramasundaram Pitchiaya, Rohit Malik, Vishal Kothari, Yasuyuki Hosono, Anastasia K. Yocum, Harika Gundlapalli, Yasmine White, Ari Firestone, Xuhong Cao, Saravana M. Dhanasekaran, Jeanne A. Stuckey, Gideon Bollag, Kevin Shannon, Nils G. Walter, Chandan Kumar-Sinha, Arul M. Chinnaiyan
Publikováno v:
Cell Reports, Vol 14, Iss 6, Pp 1448-1461 (2016)
Oncogenic mutations in RAS provide a compelling yet intractable therapeutic target. Using co-immunoprecipitation mass spectrometry, we uncovered an interaction between RAS and Argonaute 2 (AGO2). Endogenously, RAS and AGO2 co-sediment and co-localize
Externí odkaz:
https://doaj.org/article/f133faf0e1bf409685a3407f3bf3ecbb
Autor:
Xinrui Yuan, Kathryn L. Howie, Mona Kazemi Sabzvar, Krishnapriya Chinnaswamy, Jeanne A. Stuckey, Chao-Yie Yang
Publikováno v:
ACS Medicinal Chemistry Letters. 14:450-457
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6747fcee1e62778bd6baa2804d5363c3
https://doi.org/10.1021/acsmedchemlett.2c00537
https://doi.org/10.1021/acsmedchemlett.2c00537
Autor:
Atsunori Kaneshige, Longchuan Bai, Mi Wang, Donna McEachern, Jennifer L. Meagher, Renqi Xu, Paul D. Kirchhoff, Bo Wen, Duxin Sun, Jeanne A. Stuckey, Shaomeng Wang
Publikováno v:
Journal of Medicinal Chemistry. 66:2717-2743
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::910d3166a7e6934be080b05925fa08d6
https://doi.org/10.1021/acs.jmedchem.2c01665
https://doi.org/10.1021/acs.jmedchem.2c01665
Autor:
Zaneta Nikolovska-Coleska, Ramzi M. Mohammad, Jeanne A. Stuckey, Duxin Sun, Tao Zhang, Scott Owens, Tomasz Cierpicki, Thippeswamy Gulappa, Ahmed S.A. Mady, Amro Aboukameel, Asfar S. Azmi, Meilan Liu, Chenzhong Liao, Fardokht Abulwerdi
PDF - 3347KB, Synthesis and characterization of the lead compound 1 (UMI-59) and its analog 2 (UMI-77), additional details for used methods, and nine supplementary figures.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d2ebe7752694e8e0d74d2d706ad75de
https://doi.org/10.1158/1535-7163.22500082.v1
https://doi.org/10.1158/1535-7163.22500082.v1
Autor:
Zaneta Nikolovska-Coleska, Ramzi M. Mohammad, Jeanne A. Stuckey, Duxin Sun, Tao Zhang, Scott Owens, Tomasz Cierpicki, Thippeswamy Gulappa, Ahmed S.A. Mady, Amro Aboukameel, Asfar S. Azmi, Meilan Liu, Chenzhong Liao, Fardokht Abulwerdi
Using a high-throughput screening (HTS) approach, we have identified and validated several small-molecule Mcl-1 inhibitors (SMI). Here, we describe a novel selective Mcl-1 SMI inhibitor, 2 (UMI-77), developed by structure-based chemical modifications
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::486b43ad56418f83c2937c579d90f8f3
https://doi.org/10.1158/1535-7163.c.6536347
https://doi.org/10.1158/1535-7163.c.6536347