Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Jeanne A. Ferguson"'
Autor:
Christopher K McCann, Whitfield B Growdon, Kashmira Kulkarni-Datar, Michael D Curley, Anne M Friel, Jennifer L Proctor, Hana Sheikh, Igor Deyneko, Jeanne A Ferguson, Vinod Vathipadiekal, Michael J Birrer, Darrell R Borger, Gayatry Mohapatra, Lawrence R Zukerberg, Rosemary Foster, John R Macdougall, Bo R Rueda
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e28077 (2011)
Recent evidence links aberrant activation of Hedgehog (Hh) signaling with the pathogenesis of several cancers including medulloblastoma, basal cell, small cell lung, pancreatic, prostate and ovarian. This investigation was designed to determine if in
Externí odkaz:
https://doaj.org/article/4e6a983d320640afaf3099882befd611
Autor:
Joi Dunbar, Margaret A. Read, Joseph D. Manna, Alexander Constan, Alfredo C. Castro, Sherri Smith, Gordon Loewen, John Lee, Somarajan J. Nair, Jennifer Hoyt, Martin R. Tremblay, Julian Adams, Jeanne A. Ferguson, Jens Sydor, Veronica Campbell, Matthew Campbell, Karen McGovern, Brendan Arsenault, Marisa O. Peluso, Jylle Nevejans, Vito J. Palombella, Nigel Whitebread, Grogan Michael John, Kerrie Faia, John Soglia, Bennett Carter
Publikováno v:
Xenobiotica. 43:875-885
1. IPI-926 is a novel semisynthetic cyclopamine derivative that is a potent and selective Smoothened inhibitor that blocks the hedgehog signal transduction pathway. 2. The in vivo clearance of IPI-926 is low in mouse and dog and moderate in monkey. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50620a2c18fbef25785c49cf6a0c9deb
https://doi.org/10.3109/00498254.2013.780671
https://doi.org/10.3109/00498254.2013.780671
Autor:
Matthew Campbell, Eddy Tan, Kerry White, Vito J. Palombella, Julian Adams, James M. Conley, Jennifer Hoyt, Martin R. Tremblay, Margit Hagel, Jens Sydor, Jeanne A. Ferguson, Jill Cushing, Alfredo C. Castro, Somarajan J. Nair, Andre Lescarbeau, Melissa Pink, Joseph D. Manna, Grogan Michael John, Margaret A. Read, Caroline N. Woodward, Grace Lin, Mark L. Behnke, Teresa M. Alvarez-Diez, Michael Curtis, Lin-Chen Yu, John R. MacDougall, Karen McGovern, Brian C. Austad
Publikováno v:
Journal of medicinal chemistry. 52(14)
Recent evidence suggests that blocking aberrant hedgehog pathway signaling may be a promising therapeutic strategy for the treatment of several types of cancer. Cyclopamine, a plant Veratrum alkaloid, is a natural product antagonist of the hedgehog p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2605d8d446344a594f8572549b6a22f4
https://pubmed.ncbi.nlm.nih.gov/19522463
https://pubmed.ncbi.nlm.nih.gov/19522463
Autor:
Jeanne A. Ferguson, Bo R. Rueda, John Macdougall, Whitfield B. Growdon, Rosemary Foster, Kashmira Kulkarni-Datar
Publikováno v:
Cancer Research. 72:3285-3285
The high mortality associated with ovarian cancer is attributed to the lack of any reliable early detection method, unknown pathogenesis of the disease, and the development of recurrent and chemoresistant tumors. Current efforts have focused on the i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e3497ee2937f40771ecc331a85c32c4
https://doi.org/10.1158/1538-7445.am2012-3285
https://doi.org/10.1158/1538-7445.am2012-3285
Autor:
Darrell R. Borger, Bo R. Rueda, Whitfield B. Growdon, Jennifer Proctor, Igor V. Deyneko, Lawrence R. Zukerberg, Hana Sheikh, Christopher K. McCann, Kashmira Kulkarni-Datar, John R. MacDougall, Jeanne A. Ferguson, Michael D. Curley, Michael J. Birrer, Gayatry Mohapatra, Anne M. Friel, Vinod Vathipadiekal, Rosemary Foster
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e28077 (2011)
PLoS ONE
PLoS ONE
Background: Recent evidence links aberrant activation of Hedgehog (Hh) signaling with the pathogenesis of several cancers including medulloblastoma, basal cell, small cell lung, pancreatic, prostate and ovarian. This investigation was designed to det
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b653cd838de6c98a74002bb446b9701
https://doi.org/10.1371/journal.pone.0028077
https://doi.org/10.1371/journal.pone.0028077