Zobrazeno 1 - 6 of 6 pro vyhledávání: '"Jeanna M. MacLeod"'
1
Pilot study of jadomycin B pharmacokinetics and anti-tumoral effects in zebrafish larvae and mouse breast cancer xenograft models
Autor: Brendan T. McKeown, Nicholas J. Relja, Steven R. Hall, Simon Gebremeskel, Jeanna M. MacLeod, Chansey J. Veinotte, Leah G. Bennett, Leanne B. Ohlund, Lekha Sleno, David L. Jakeman, Jason N. Berman, Brent Johnston, Kerry B. Goralski
Publikováno v: Canadian journal of physiology and pharmacology.
Despite numerous therapeutic options, multidrug resistance (MDR) remains an obstacle to successful breast cancer therapy. Jadomycin B, a natural product derived from Streptomyces venezuelae ISP5230, maintains cytotoxicity in MDR human breast cancer c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c70c6903b80acd37bf861bf222a295d3
https://pubmed.ncbi.nlm.nih.gov/35985040
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3
Isolation of a post-PKS C–C branching jadomycin from S. venezuelae ISP5230 in the presence of 8-aminooctanoic acid
Autor: Stephanie M. Forget, Jeanna M. MacLeod, Camilo F. Martinez-Farina, David L. Jakeman
Publikováno v: Canadian Journal of Chemistry. 96:760-764
The jadomycin family of natural products was first identified and characterized by Vining and co-workers at Dalhousie University in the 1990s. Herein, we report findings from a recently developed co-amino acid supplementation culture method with S. v
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::97c4021fc11dfe6d1400c9dbd8a72c4d
https://doi.org/10.1139/cjc-2017-0572
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4
The expansive library of jadomycins
Autor: Jeanna M. MacLeod, David L. Jakeman, Stephanie M. Forget
Publikováno v: Canadian Journal of Chemistry. 96:495-501
The jadomycin family of natural products was discovered from Streptomyces venezuelae ISP5230 in the 1990s. Subsequent identification of the biosynthetic gene cluster along with synthetic efforts established that incorporation of an amino acid into th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3957d2fe709d102139f260fb387a953b
https://doi.org/10.1139/cjc-2017-0573
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5
Isolation of a jadomycin incorporating l-ornithine, analysis of antimicrobial activity and jadomycin reactive oxygen species (ROS) generation in MDA-MB-231 breast cancer cells
Autor: Steven R. Hall, Stephanie M. Forget, Jeanna M. MacLeod, Russell G. Kerr, Andrew W. Robertson, David L. Jakeman, David P. Overy, Kerry B. Goralski
Publikováno v: The Journal of Antibiotics. 71:722-730
Herein, we report the characterization and antimicrobial activity of a previously unreported jadomycin (1) obtained from a culture of S. venezuelae ISP5230 with l-ornithine (Orn). 1 arises from the rearrangement of a putative five-membered ring conta
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::659898869f0712c40109e00c64973a95
https://doi.org/10.1038/s41429-018-0060-0
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6
Post Polyketide Synthase Carbon–Carbon Bond Formation in Type-II PKS-Derived Natural Products from Streptomyces venezuelae
Autor: Leah G. Bennett, David L. Jakeman, Hebelin Correa, Kerry B. Goralski, Jeanna M. MacLeod, Steven R. Hall, Russell G. Kerr, Stephanie M. Forget, Andrew W. Robertson, Logan W. MacIntyre
Publikováno v: The Journal of Organic Chemistry. 83:1876-1890
Polyketide synthase (PKS) derived natural products are biosynthesized by head-to-tail addition of acetate and malonate extender units resulting in linear extended-polyketide chains. Despite the well-documented structural diversity associated with PKS
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c34673c611f63401b2a7fb5cfe55e86a
https://doi.org/10.1021/acs.joc.7b02823
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