Zobrazeno 1 - 10 of 31 pro vyhledávání: '"Jeanine Laur"'
1
Phenylethylamide derivatives of the C-terminal tetrapeptide of gastrin
Autor: Jean-Pierre Bali, Jean Martinez, Marc Rodriguez, Jeanine Laur
Publikováno v: International Journal of Peptide and Protein Research. 28:529-535
Peptide analogues of the C-terminal tetrapeptide of gastrin in which the phenylalanine had been replaced were synthesized and their biological activity on acid secretion evaluated. Compounds Boc-Trp-Leu-Asp phenylethylamide 6, Boc-beta-Ala-Trp-Leu-As
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b29e8e7083a577575b49459bc377c80a
https://doi.org/10.1111/j.1399-3011.1986.tb03288.x
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2
Synthesis and biological evaluation of cholecystokinin analogs in which the Asp-Phe-NH2 moiety has been replaced by a 3-amino-7-phenylheptanoic acid or a 3-amino-6-(phenyloxy)hexanoic acid
Autor: J. C. Califano, L. Hauad, Marie-Françoise Lignon, Muriel Amblard, A M Artis-Noël, M. Rodriguez, A. Aumelas, Jeanine Laur, Marie-Christine Galas, Nicole Bernad
Publikováno v: Journal of Medicinal Chemistry. 36:3021-3028
Boc-Tyr(SO3H)-Nle-Gly-Trp-Nle-Asp-2-phenylethyl ester (JMV180), an analog of the C-terminal octapeptide of cholecystokinin (CCK-8), shows interesting biological activities behaving as an agonist at the high-affinity CCK binding sites and as an antago
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b8f1afd1094ec4d537acbb1ccf7340d
https://doi.org/10.1021/jm00072a024
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3
Biological effects of human gastrin I and II chemically modified at the tetrapeptide amide
Autor: Richard Magous, Jeanine Laur, J. C. Galleyrand, P. Fulcrand, Jean Martinez, Marc Rodriguez, Jean-Pierre Bali
Publikováno v: Peptides. 13:519-525
Binding to gastrin receptors and gastric acid secretion experiments were performed with gastrin derivatives modified at the C- terminal tetrapeptide amide from HG-13 sequence. 1. When the ultimate phenylalanine amide was replaced by a phenethylester
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ab591fe86c8c9d126ae45413f9d6331b
https://doi.org/10.1016/0196-9781(92)90083-f
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4
Synthesis and biological activities of cholecystokinin analogues substituted in position 30 by 3-(1-naphthyl)-l-alanine [Nal(1)] or 3-(2-naphthyl)-l-alanine [Nal(2)]
Autor: Jean Martinez, André Aumelas, Marc Rodriguez, M F Lignon, N Bernad, Jeanine Laur, Marie-Christine Galas
Publikováno v: European Journal of Medicinal Chemistry. 26:245-253
Acetyl derivatives of ethyl esters of 3-(1-naphthyl)- d,l -alanine and 3-(2-naphthyl)- d,l -alanine were synthesized through a malonic condensation. Resolution of these derivatives by subtilisin Carlsberg followed by acid hydrolysis afforded the 2 op
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8b0188d6d623cb8989468b781bdc6c75
https://doi.org/10.1016/0223-5234(91)90056-s
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5
ACE-like hydrolysis of gastrin analogs and CCK-8 by fundic mucosal cells of different species with release of the amidated C-terminal dipeptide
Autor: P. Fulcrand, Philibert Dubreuil, Marc Rodriguez, Jean Martinez, Jeanine Laur, Jean-Pierre Bali
Publikováno v: Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 1039:171-176
Various gastrin analogues and CCK-8 (Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2) are hydrolyzed in vitro by angiotensin-converting enzyme (ACE), the main and initial cleavage occuring at the Met-Asp (or Leu-Asp) bond, releasing the C-terminal dipeptid
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::453f46c3f687e0ab819a7e0de2547629
https://doi.org/10.1016/0167-4838(90)90182-f
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6
Biosynthesis and posttranslational processing of the neurotensin/neuromedin N precursor in the rat medullary thyroid carcinoma 6-23 cell line. Effect of dexamethasone
Autor: F de Nadai, Jean Martinez, Carole Rovère, Jean-Claude Cuber, Jeanine Laur, Patrick Kitabgi, Jean-Noël Bidard
Publikováno v: Endocrinology
Endocrinology, Endocrine Society, 1993, 132 (4), pp.1614-1620
Neurotensin (NT) and Neuromedin N (NN) are two biologically active peptides present in one copy each in the C-terminal region of a 169-residue precursor. Four basic Lys-Arg doublets occur within the precursor and represent putative processing sites.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fbc3fdda8096e8b554db61170cf272c
https://pubmed.ncbi.nlm.nih.gov/8462460
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7
Immunological and biochemical characterization of processing products from the neurotensin/neuromedin N precursor in the rat medullary thyroid carcinoma 6-23 cell line
Autor: Jeanine Laur, F de Nadai, Jean-Noël Bidard, Jean-Claude Cuber, Carole Rovère, Patrick Kitabgi, Jean Martinez, D Moinier
Publikováno v: Biochemical Journal
Biochemical Journal, Portland Press, 1993, 291, pp.225-233
Neurotensin (NT) and neuromedin N (NN) are two related biologically active peptides that are encoded in the same precursor molecule. In the rat, the precursor consists of a 169-residue polypeptide starting with an N-terminal signal peptide and contai
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee8c63c2d280f52a9b06b8d715f69564
https://hal.inrae.fr/hal-02706900
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9
Pharmacological profile of a new peptidic gastrin antagonist
Autor: Jean-Pierre Bali, Bertrand Castro, A. Lavezzo, Marie-Françoise Lignon, D. Nisato, Jeanine Laur, Jean Martinez, Richard Magous
Publikováno v: Regulatory Peptides. 15:111-119
Boc-Trp-Met-Asp-NH2 was described as the smallest peptidic fragment which presented gastric antisecretory activity. Some pharmacological aspects of a peptide analogue, Boc-Trp-Leu-Asp-NH2 (Boc-WLD-NH2), were studied on the main biological functions o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db8d565417d0f54fc1282f1c558b9c6c
https://doi.org/10.1016/0167-0115(86)90081-9
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10
A pseudopeptide that is a potent cholecystokinin agonist in the peripheral system is able to inhibit the dopamine-like effects of cholecystokinin in the striatum
Autor: Jean Martinez, M F Lignon, Jeanine Laur, Marie-Christine Galas, C Gueudet, Christiane Mendre, M Rodriquez, P Worms
Publikováno v: Scopus-Elsevier
There are no known specific effective cholecystokinin (CCK) receptor antagonists of both peripheral and central nervous systems. Here, we describe experiments which demonstrate that a synthetic pseudopeptide analogue of CCK-7 is a potent agonist in t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db70e921ec21ef1a3739d8097217266c
https://doi.org/10.1016/s0021-9258(18)38019-0
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