Correlation between infectivity and disease associated prion protein in the nervous system and selected edible tissues of naturally affected scrapie sheep.

Autor: Francesca Chianini, Gian Mario Cosseddu, Philip Steele, Scott Hamilton, Jeremy Hawthorn, Sílvia Síso, Yvonne Pang, Jeanie Finlayson, Samantha L Eaton, Hugh W Reid, Mark P Dagleish, Michele Angelo Di Bari, Claudia D'Agostino, Umberto Agrimi, Linda Terry, Romolo Nonno

Publikováno v: PLoS ONE, Vol 10, Iss 3, p e0122785 (2015)

The transmissible spongiform encephalopathies (TSEs) or prion diseases are a group of fatal neurodegenerative disorders characterised by the accumulation of a pathological form of a host protein known as prion protein (PrP). The validation of abnorma

Externí odkaz: https://doaj.org/article/de5b46fc903d471aa59aedf8775c99ce

Transcriptional Response of Ovine Lung to Infection with Jaagsiekte Sheep Retrovirus

Autor: Chris Cousens, Deepali Vasoya, Ann R. Wood, Anna E. Karagianni, Jeanie Finlayson, Mark P. Dagleish, Mick Watson, Henny M. Martineau, David J. Griffiths

Publikováno v: Journal of Virology
Karagianni, A, Vasoya, D, Finlayson, J, Martineau, H, Wood, A R, Cousens, C, Dalgleish, M P, Watson, M & Griffiths, D J 2019, ' Transcriptional response of ovine lung to infection with jaagsiekte sheep retrovirus ', Journal of Virology . https://doi.org/10.1128/JVI.00876-19

Ovine pulmonary adenocarcinoma is a chronic respiratory disease of sheep caused by jaagsiekte sheep retrovirus (JSRV). OPA is a significant economic problem for sheep farmers in many countries and is a valuable animal model for some forms of human lu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c67f0b800eb6fcf6b7bc80fed61a0462
https://pubmed.ncbi.nlm.nih.gov/31434729

Precision resection of lung cancer in a sheep model using ultrashort laser pulses

Autor: Mark P. Dagleish, Jonathan D. Shephard, Syam Mohan P. C. Mohanan, Wojciech Stanisław Góra, David J. Griffiths, Jeanie Finlayson, Chris Cousens, Rainer J. Beck

Publikováno v: SPIE Proceedings.

Recent developments and progress in the delivery of high average power ultrafast laser pulses enable a range of novel minimally invasive surgical procedures. Lung cancer is the leading cause of cancer deaths worldwide and here the resection of lung t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7f6c1d8690bef24c1233270781d5e4d9
https://doi.org/10.1117/12.2252215

Pathogenesis of scrapie in ARQ/ARQ sheep after subcutaneous infection: Effect of lymphadenectomy and immune cell subset changes in relation to prion protein accumulation

Autor: Yvonne Pang, Carlo Cantile, Scott L. Hamilton, Philip Steele, Lorenzo González, Martin Jeffrey, Sílvia Sisó, Hugh W. Reid, Mark P. Dagleish, Francesca Chianini, Jill Sales, Samantha L. Eaton, Emanuele Ricci, Jeanie Finlayson

Publikováno v: Veterinary Immunology and Immunopathology. 152:348-358

It is well established that the infectious agent of scrapie can replicate in the lymphoreticular system (LRS). However, the effects of removal of LRS target tissues on the pathogenesis of the infection and the accumulation of disease-associated prion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9959032a61b5013c6e5ff6b4fc2ce059
https://doi.org/10.1016/j.vetimm.2013.01.005

Naturally prion resistant mammals

Autor: Mark P. Dagleish, Francesca Chianini, Joaquín Castilla, Hasier Eraña, Jeanie Finlayson, Natalia Fernández-Borges, Samantha L. Eaton, Enric Vidal, Belén Pintado

Publikováno v: Prion. 6:425-429

Each known abnormal prion protein (PrP (Sc) ) is considered to have a specific range and therefore the ability to infect some species and not others. Consequently, some species have been assumed to be prion disease resistant as no successful natural

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11d412945f4c963bfc92b6fe80d1dda9
https://doi.org/10.4161/pri.22057