Výsledky vyhledávání - "Jeanette M.G. van Gool"

Methodologic Issues in the Measurement of Urinary Renin

Autor: A.H. Jan Danser, Ingrid M. Garrelds, Lodi C.W. Roksnoer, Jeanette M.G. van Gool, Koen Verdonk, Robert Zietse, Ewout J. Hoorn

Publikováno v: Clinical Journal of the American Society of Nephrology, 9(7), 1163-1167. American Society of Nephrology

Background and objectives Alge et al. recently reported that urinary renin may be a prognostic biomarker for AKI after cardiac surgery. However, their urinary renin levels far exceeded published plasma renin levels, whereas normally, urinary renin is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f46a7b9a617f8a71b9e904670fe6c8fb
https://doi.org/10.2215/cjn.12661213

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Urinary renin, but not angiotensinogen or aldosterone, reflects the renal renin-angiotensin-aldosterone system activity and the efficacy of renin-angiotensin-aldosterone system blockade in the kidney

Autor: Ingrid M. Garrelds, A.H. Jan Danser, Anton H. van den Meiracker, Wendy W. Batenburg, Sjaam Jainandunsing, Jeanette M.G. van Gool, Richard A Feelders, Mieke van den Heuvel

Publikováno v: Journal of Hypertension, 29(11), 2147-2155. Lippincott Williams & Wilkins

Objective To study which renin-angiotensin-aldosterone system (RAAS) component best reflects renal RAAS activity. Methods and results We measured urinary and plasma renin, prorenin, angiotensinogen, aldosterone, albumin and creatinine in 101 diabetic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d6c85f787e6be042ab7f80927582cff
https://doi.org/10.1097/hjh.0b013e32834bbcbf

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Aliskiren Accumulates in Renin Secretory Granules and Binds Plasma Prorenin

Autor: Manne Krop, Naomi D.L. Fisher, Jeanette M.G. van Gool, Ingrid M. Garrelds, Norman K. Hollenberg, René J.A. de Bruin, A.H. Jan Danser

Publikováno v: Hypertension, 52(6), 1076-1083. Lippincott Williams & Wilkins

The vascular effects of aliskiren last longer than expected based on its half life, and this renin inhibitor has been reported to cause a greater renin rise than other renin-angiotensin system blockers. To investigate whether aliskiren accumulation i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42fe25746aa78c6b87f7df33142bc7ed
https://hdl.handle.net/1765/29421

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New renin inhibitor VTP-27999 alters renin immunoreactivity and does not unfold prorenin

Autor: A.H. Jan Danser, Maarten A.D.H. Schalekamp, Jeanette M.G. van Gool, Richard Gregg, Manne Krop, Koen Verdonk, Xifeng Lu, Brian M. McKeever

Publikováno v: Hypertension, 61(5), 1075-+. Lippincott Williams & Wilkins

Renin inhibitors like aliskiren not only block renin but also bind prorenin, thereby inducing a conformational change (like the change induced by acid) allowing its recognition in a renin-specific assay. Consequently, aliskiren can be used to measure

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fdb515ce1edcda1a022764f62532b39
https://pubmed.ncbi.nlm.nih.gov/23460288

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Evaluation of a direct prorenin assay making use of a monoclonal antibody directed against residues 32-39 of the prosegment

Autor: Alexander H. J. Danser, Duane Day, Jeanette M.G. van Gool, Norman K. Hollenberg, Manne Krop

Publikováno v: Journal of Hypertension, 29(11), 2138-2146. Lippincott Williams & Wilkins

Background Prorenin is an early marker of microvascular complications in diabetes. However, it can only be measured indirectly (following its conversion to renin), with a renin immunoradiometric assay (IRMA). Unfortunately, treatment with a renin inh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4bf8a25fc3c9a607beefcd9546cfe9c
https://pure.eur.nl/en/publications/243135be-29cd-48a2-acd8-52c533a0960d

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Cardiac Renin Levels Are Not Influenced by the Amount of Resident Mast Cells

Autor: Manne Krop, Marco Thio, René J.A. de Bruin, A.H. Jan Danser, Jeanette M.G. van Gool, Paul L.A. van Daele, Anton H. van den Meiracker, Ingrid M. Garrelds, Richard van Veghel

Publikováno v: Hypertension, 54(2), 315-321. Lippincott Williams & Wilkins

To investigate whether mast cells release renin in the heart, we studied renin and prorenin synthesis by such cells, using the human mast cell lines human mastocytoma 1 and LAD2, as well as fresh mast cells from mastocytosis patients. We also quantif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fba903039598f2a7a49b937a616b0a6b
https://pure.eur.nl/en/publications/d54ce723-1412-4579-b60a-4b1a283b0197

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Aliskiren-binding increases the half life of renin and prorenin in rat aortic vascular smooth muscle cells

Autor: Jeanette M.G. van Gool, Dominik N. Müller, René J.A. de Bruin, Michael Bader, A.H. Jan Danser, Wendy W. Batenburg, Geneviève Nguyen

Publikováno v: Arteriosclerosis Thrombosis & Vascular Biology, 28(6), 1151-1157. Lippincott Williams & Wilkins

Objective— Renin inhibition with aliskiren has been reported to cause a greater rise in renin than other types of renin-angiotensin system blockade, thereby potentially leading to angiotensin generation or stimulation of the human (pro)renin recept

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76e1d6d1ec351488d1e5222caddf0439
https://pubmed.ncbi.nlm.nih.gov/18388329

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Different contributions of the angiotensin-converting enzyme C-domain and N-domain in subjects with the angiotensin-converting enzyme II and DD genotype

Autor: Hugh Montgomery, Magda Hectors, René J.A. de Bruin, Jaap Deinum, Joep H.M. van Esch, Vincent Dive, John R. Payne, Jeanette M.G. van Gool, A.H. Jan Danser

Publikováno v: Journal of Hypertension, 26, 4, pp. 706-13
Journal of Hypertension, 26(4), 706-713. Lippincott Williams & Wilkins
Journal of Hypertension, 26, 706-13

Contains fulltext : 70132.pdf (Publisher’s version ) (Closed access) BACKGROUND: Angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism-related differences in ACE concentration do not result in differences in angiotensin levels.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf3b03b77c6ab73949a7b7c6bce56aa8
https://doi.org/10.1097/HJH.0b013e3282f465d2

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