Zobrazeno 1 - 10 of 27 pro vyhledávání: '"Jeanette Dilley"'
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Akademický článek
Appetite enhancement and weight gain by peripheral administration of TrkB agonists in non-human primates.
Autor: John C Lin, David Tsao, Paul Barras, Raul A Bastarrachea, Bob Boyd, Joyce Chou, Rodnie Rosete, Hua Long, Alison Forgie, Yasmina Abdiche, Jeanette Dilley, Jennifer Stratton, Carlos Garcia, David L Sloane, Anthony G Comuzzie, Arnon Rosenthal
Publikováno v: PLoS ONE, Vol 3, Iss 4, p e1900 (2008)
Loss of function mutations in the receptor tyrosine kinase TrkB pathway resulted in hyperphagia and morbid obesity in human and rodents. Conversely, peripheral or central stimulation of TrkB by its natural ligands BDNF or NT4 reduced body weight and
Externí odkaz: https://doaj.org/article/6efe3da8a10f430793c6095c8907968a
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3
Anti–IL-7 receptor-α reverses established type 1 diabetes in nonobese diabetic mice by modulating effector T-cell function
Autor: Colleen Brown, John C. Lin, Li Mei, Timothy Affolter, Jessica Yu, Sherman Michael Chin, Jeanette Dilley, Irene Ni, Wenwu Zhai, Bora Han, Arvind Rajpal, Kathryn Logronio, Guang Huan Tu, Li-Fen Lee, Charles Takeshi Appah
Publikováno v: Proceedings of the National Academy of Sciences. 109:12674-12679
Genetic variation in the IL-7 receptor-α ( IL-7R ) gene is associated with susceptibility to human type 1 diabetes (T1D). Here we investigate the therapeutic efficacy and mechanism of IL-7Rα antibody in a mouse model of T1D. IL-7Rα antibody induce
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::118df3cc4d7cde592d22227550353b6a
https://doi.org/10.1073/pnas.1203795109
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4
Oncolytic adenovirus CG7870 in combination with radiation demonstrates synergistic enhancements of antitumor efficacy without loss of specificity
Autor: Jeanette Dilley, Seshidhar Reddy, Derek Ko, Natalie Nguyen, Ginny Rojas, Peter Working, De-Chao Yu
Publikováno v: Cancer Gene Therapy. 12:715-722
Conditionally replicating adenoviruses that selectively replicate in tumor cells, but not in normal cells, are being explored as virotherapeutic agents for cancer. A prostate-specific oncolytic adenovirus, CG7870 is currently being evaluated in phase
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::150d13a288b54a9c35e214a913f70395
https://doi.org/10.1038/sj.cgt.7700835
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6
High-affinity IgG antibodies develop naturally in Ig-knockout rats carrying germline human IgH/Igκ/Igλ loci bearing the rat CH region
Autor: Xi Yang, Ignacio Anegon, Anne-Laure Iscache, Laure-Hélène Ouisse, Roland Buelow, Marianne Brüggemann, Jeanette Dilley, Kevin Lindquist, Arvind Rajpal, Biao Ma, Michael S. Neuberger, Séverine Ménoret, Michael J. Osborn, Ashleigh Binnie, Suzanne Avis
Publikováno v: Journal of Immunology
Journal of Immunology, 2013, 190 (4), pp.1481-1490. ⟨10.4049/jimmunol.1203041⟩
Mice transgenic for human Ig loci are an invaluable resource for the production of human Abs. However, such mice often do not yield human mAbs as effectively as conventional mice yield mouse mAbs. Suboptimal efficacy in delivery of human Abs might re
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::671e3b32be1fee20b5db04c6eccb5ca6
https://pubmed.ncbi.nlm.nih.gov/23303672
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7
Noninvasive Localization of Experimental Atherosclerotic Lesions With Mouse/Human Chimeric Z2D3 F(ab′) 2 Specific for the Proliferating Smooth Muscle Cells of Human Atheroma
Autor: Isabella Pieslak, Ban-An Khaw, Cesario Bianchi, Vladimir P. Torchilin, Jeanette Dilley, Charles C. Ditlow, Artiom Petrov, Francis Chen, Bradford C. Lister, Jagat Narula
Publikováno v: Circulation. 92:474-484
Background A murine monoclonal antibody designated Z2D3 (IgM) generated against homogenized human atherosclerotic plaques was demonstrated to be highly specific for proliferating smooth muscle cells. The primary clone subsequently was genetically eng
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d5226095afa355f806ad341fb9471212
https://doi.org/10.1161/01.cir.92.3.474
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8
Proprotein convertase substilisin/kexin type 9 antagonism reduces low-density lipoprotein cholesterol in statin-treated hypercholesterolemic nonhuman primates
Autor: Hong Liang, Lanfang Bai, Janette Sutton, Yasmina Noubia Abdiche, Javier Chaparro-Riggers, Andrea Rossi, John C. Lin, David L. Shelton, Daniel Tsai, Tao Geng, S. Michael Chin, Si Wu, Jessica Yu, Jeanette Dilley, Pavel Strop, Jaume Pons, Nicole A. Lee, Arvind Rajpal
Publikováno v: The Journal of pharmacology and experimental therapeutics. 340(2)
Proprotein convertase substilisin/kexin type 9 (PCSK9) promotes the degradation of low-density lipoprotein (LDL) receptor (LDLR) and thereby increases serum LDL-cholesterol (LDL-C). We have developed a humanized monoclonal antibody that recognizes th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13f5b74b8407a6494e4945b3e7e17a1f
https://pubmed.ncbi.nlm.nih.gov/22019884
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9
Anti-amyloid therapy protects against retinal pigmented epithelium damage and vision loss in a model of age-related macular degeneration
Autor: Jaume Pons, Stephanie G. Smith, Catherine Bowes Rickman, Dione Kobayashi, Lincoln V. Johnson, Brian E. Mace, Wenlin Li, Una Kelly, Jeffrey A. Jamison, John C. Lin, Bing Kuang, Marybeth Groelle, Rolf Herrmann, Sangeetha Bollini, Ons Harrabi, Jindong Ding, Patrick Sullivan, Sina Farsiu, Jeanette Dilley
Publikováno v: Proceedings of the National Academy of Sciences. 108
Age-related macular degeneration (AMD) is a leading cause of visual dysfunction worldwide. Amyloid β (Aβ) peptides, Aβ1–40 (Aβ40) and Aβ1–42 (Aβ42), have been implicated previously in the AMD disease process. Consistent with a pathogenic ro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c02e2ee664dea5c5924f6030e92f220c
https://doi.org/10.1073/pnas.1100901108
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10
IL-7 Promotes T(H)1 Development and Serum IL-7 Predicts Clinical Response to Interferon-beta in Multiple Sclerosis
Autor: Lawrence Steinman, Kathryn Logronio, Robert C. Axtell, Brigit A. de Jong, Joep Killestein, Chris H. Polman, Li-Fen Lee, Mathias Rickert, Jing Shi, Michael G. Walker, Winston Evering, John C. Lin, Jessica Yu, Jeanette Dilley, Guang Huan Tu, Bora Han
Publikováno v: Lee, L F, Axtell, R, Tu, G H, Logronio, K, Dilley, J, Yu, J, Rickert, M, Han, B, Evering, W, Walker, M G, Shi, J, de Jong, B A, Killestein, J, Polman, C H, Steinman, L & Lin, J C 2011, ' IL-7 Promotes T(H)1 Development and Serum IL-7 Predicts Clinical Response to Interferon-beta in Multiple Sclerosis ', Science Translational Medicine, vol. 3, no. 93 . https://doi.org/10.1126/scitranslmed.3002400
Science Translational Medicine, 3, 93, pp. 93ra68-93ra68
Science Translational Medicine, 3, 93ra68-93ra68
Science Translational Medicine, 3(93). American Association for the Advancement of Science
Item does not contain fulltext The interleukin-7 receptor alpha chain (IL-7Ralpha) gene was identified as a top non-major histocompatibility complex-linked risk locus for multiple sclerosis (MS). Recently, we showed that a T helper 1 (T(H)1)-driven,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f427701a74d288d8edea252ff3c5ec2b
https://research.vumc.nl/en/publications/f87fbd48-d0e0-4135-b7c3-080edb62517b
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