Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Jeanette Baran-Gale"'
Autor:
Vijay Swahari, Ayumi Nakamura, Emilie Hollville, Yu-Han Hung, Matt Kanke, C. Lisa Kurtz, Xurde M. Caravia, David Roiz-Valle, Shenghui He, Janakiraman Krishnamurthy, Sahil Kapoor, Varun Prasad, Cornelius Flowers, Matt Beck, Jeanette Baran-Gale, Norman Sharpless, Carlos López-Otín, Praveen Sethupathy, Mohanish Deshmukh
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-11 (2024)
Abstract Aging is a consequence of complex molecular changes, but whether a single microRNA (miRNA) can drive aging remains unclear. A miRNA known to be upregulated during both normal and premature aging is miR-29. We find miR-29 to also be among the
Externí odkaz:
https://doaj.org/article/d2e2c9171b5d43a3bb38718b4bf3ccda
Autor:
Jeanette Baran-Gale, Michael D Morgan, Stefano Maio, Fatima Dhalla, Irene Calvo-Asensio, Mary E Deadman, Adam E Handel, Ashley Maynard, Steven Chen, Foad Green, Rene V Sit, Norma F Neff, Spyros Darmanis, Weilun Tan, Andy P May, John C Marioni, Chris P Ponting, Georg A Holländer
Publikováno v:
eLife, Vol 9 (2020)
Ageing is characterised by cellular senescence, leading to imbalanced tissue maintenance, cell death and compromised organ function. This is first observed in the thymus, the primary lymphoid organ that generates and selects T cells. However, the mol
Externí odkaz:
https://doaj.org/article/0801b66fbced40e4a16cb9a6776b1379
Autor:
Vijay Swahari, Ayumi Nakamura, Jeanette Baran-Gale, Idoia Garcia, Andrew J. Crowther, Robert Sons, Timothy R. Gershon, Scott Hammond, Praveen Sethupathy, Mohanish Deshmukh
Publikováno v:
Cell Reports, Vol 14, Iss 2, Pp 216-224 (2016)
Maintenance of genomic integrity is critical during neurodevelopment, particularly in rapidly dividing cerebellar granule neuronal precursors that experience constitutive replication-associated DNA damage. As Dicer was recently recognized to have an
Externí odkaz:
https://doaj.org/article/13f836ab698c4ab4a62a44214dc9e213
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 5, Pp 1182-1191 (2013)
MicroRNAs (miRNAs) are key posttranscriptional regulators of biological pathways that govern lipid metabolic phenotypes. Recent advances in high-throughput small RNA sequencing technology have revealed the complex and dynamic repertoire of miRNAs. Sp
Externí odkaz:
https://doaj.org/article/93ed1601f26b4037a98545013f924f7a
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e73240 (2013)
Next-generation deep sequencing of small RNAs has unveiled the complexity of the microRNA (miRNA) transcriptome, which is in large part due to the diversity of miRNA sequence variants ("isomiRs"). Changes to a miRNA's seed sequence (nucleotides 2-8),
Externí odkaz:
https://doaj.org/article/10ea210945394fac81570d9479a84dfa
Autor:
Vijay Swahari, Ayumi Nakamura, Emilie Hollville, Yu-Han Hung, Matt Kanke, C. Lisa Kurtz, Xurde M. Caravia, Shenghui He, Janakiraman Krishnamurthy, Sahil Kapoor, Varun Prasad, Cornelius Flowers, Matt Beck, Jeanette Baran-Gale, Norman Sharpless, Carlos López-Otín, Praveen Sethupathy, Mohanish Deshmukh
Aging is a consequence of complex molecular changes, but the roles of individual microRNAs (miRNAs) in aging remain unclear. One of the few miRNAs that are upregulated during both normal and premature aging is miR-29. We confirmed this finding in our
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33a994edc9ccecdf3c3cbf15a39b5bbb
https://doi.org/10.1101/2022.11.29.518429
https://doi.org/10.1101/2022.11.29.518429
Autor:
Norma F. Neff, Jeanette Baran-Gale, Ashley Maynard, Fatima Dhalla, Rene Sit, Chris P. Ponting, AP May, Weilun Tan, Steven Chen, Foad Green, Georg A. Holländer, Morgan, Adam E. Handel, Stefano Maio, John C. Marioni, Spyros Darmanis, Mary E. Deadman, Irene Calvo-Asensio
Publikováno v:
eLife
Baran-Gale, J, Morgan, M D, Maio, S, Dhalla, F, Calvo-Asensio, I, Deadman, M E, Handel, A E, Maynard, A, Chen, S, Green, F, Sit, R V, Neff, N F, Darmanis, S, Tan, W, May, A P, Marioni, J C, Ponting, C P & Holländer, G A 2020, ' Ageing compromises mouse thymus function and remodels epithelial cell differentiation ', eLIFE, vol. 9, no. 8, e56221 . https://doi.org/10.7554/eLife.56221
eLife, Vol 9 (2020)
eLife, 9
Baran-Gale, J, Morgan, M D, Maio, S, Dhalla, F, Calvo-Asensio, I, Deadman, M E, Handel, A E, Maynard, A, Chen, S, Green, F, Sit, R V, Neff, N F, Darmanis, S, Tan, W, May, A P, Marioni, J C, Ponting, C P & Holländer, G A 2020, ' Ageing compromises mouse thymus function and remodels epithelial cell differentiation ', eLIFE, vol. 9, no. 8, e56221 . https://doi.org/10.7554/eLife.56221
eLife, Vol 9 (2020)
eLife, 9
Ageing is characterised by cellular senescence, leading to imbalanced tissue maintenance, cell death and compromised organ function. This is first observed in the thymus, the primary lymphoid organ that generates and selects T cells. However, the mol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8fc8a5ee53b84a3b59dd1f67e8e1170
Autor:
Mary E. Deadman, Stefano Maio, Irene Calvo-Asensio, Michael D Morgan, Rene Sit, Ashley Maynard, Jeanette Baran-Gale, Georg A. Holländer, Foad Green, Chris P. Ponting, Andy P May, Spyros Darmanis, Fatima Dhalla, Adam E. Handel, John C. Marioni, Norma Neff, Steven Chen, Weilun Tan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::236b8e956ec9ca76520abca1824add7b
https://doi.org/10.7554/elife.56221.sa2
https://doi.org/10.7554/elife.56221.sa2
Autor:
Stefano Maio, Jeanette Baran-Gale, Chris P. Ponting, Fatima Dhalla, Lia Chappell, Georg A. Holländer
Publikováno v:
Dhalla, F, Baran-Gale, J, Maio, S, Chappell, L, Holländer, G A & Ponting, C P 2020, ' Biologically indeterminate yet ordered promiscuous gene expression in single medullary thymic epithelial cells ', EMBO Journal, vol. 39, e101828 . https://doi.org/10.15252/embj.2019101828
The EMBO Journal
The EMBO Journal
To induce central T‐cell tolerance, medullary thymic epithelial cells (mTEC) collectively express most protein‐coding genes, thereby presenting an extensive library of tissue‐restricted antigens (TRAs). To resolve mTEC diversity and whether pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6bb5ec1ea07a218b0293599a04e4a4a
Publikováno v:
Europe PubMed Central
Journal of Integrative Bioinformatics, Vol 13, Iss 5, Pp 47-56 (2016)
Journal of Integrative Bioinformatics, Vol 13, Iss 5, Pp 47-56 (2016)
Small non-coding RNAs, in particular microRNAs, are critical for normal physiology and are candidate biomarkers, regulators, and therapeutic targets for a wide variety of diseases. There is an ever-growing interest in the comprehensive and accurate a