A large-scale genome-wide association study meta-analysis of cannabis use disorder

Autor: Emma C Johnson, Ditte Demontis, Thorgeir E Thorgeirsson, Raymond K Walters, Renato Polimanti, Alexander S Hatoum, Sandra Sanchez-Roige, Sarah E Paul, Frank R Wendt, Toni-Kim Clarke, Dongbing Lai, Gunnar W Reginsson, Hang Zhou, June He, David A A Baranger, Daniel F Gudbjartsson, Robbee Wedow, Daniel E Adkins, Amy E Adkins, Jeffry Alexander, Silviu-Alin Bacanu, Tim B Bigdeli, Joseph Boden, Sandra A Brown, Kathleen K Bucholz, Jonas Bybjerg-Grauholm, Robin P Corley, Louisa Degenhardt, Danielle M Dick, Benjamin W Domingue, Louis Fox, Alison M Goate, Scott D Gordon, Laura M Hack, Dana B Hancock, Sarah M Hartz, Ian B Hickie, David M Hougaard, Kenneth Krauter, Penelope A Lind, Jeanette N McClintick, Matthew B McQueen, Jacquelyn L Meyers, Grant W Montgomery, Ole Mors, Preben B Mortensen, Merete Nordentoft, John F Pearson, Roseann E Peterson, Maureen D Reynolds, John P Rice, Valgerdur Runarsdottir, Nancy L Saccone, Richard Sherva, Judy L Silberg, Ralph E Tarter, Thorarinn Tyrfingsson, Tamara L Wall, Bradley T Webb, Thomas Werge, Leah Wetherill, Margaret J Wright, Stephanie Zellers, Mark J Adams, Laura J Bierut, Jason D Boardman, William E Copeland, Lindsay A Farrer, Tatiana M Foroud, Nathan A Gillespie, Richard A Grucza, Kathleen Mullan Harris, Andrew C Heath, Victor Hesselbrock, John K Hewitt, Christian J Hopfer, John Horwood, William G Iacono, Eric O Johnson, Kenneth S Kendler, Martin A Kennedy, Henry R Kranzler, Pamela A F Madden, Hermine H Maes, Brion S Maher, Nicholas G Martin, Matthew McGue, Andrew M McIntosh, Sarah E Medland, Elliot C Nelson, Bernice Porjesz, Brien P Riley, Michael C Stallings, Michael M Vanyukov, Scott Vrieze, Lea K Davis, Ryan Bogdan, Joel Gelernter, Howard J Edenberg, Kari Stefansson, Anders D Børglum, Arpana Agrawal, Raymond Walters, Emma Johnson, Jeanette McClintick, Alexander Hatoum, Frank Wendt, Mark Adams, Amy Adkins, Fazil Aliev, Anthony Batzler, Sarah Bertelsen, Joanna Biernacka, Tim Bigdeli, Li-Shiun Chen, Yi-Ling Chou, Franziska Degenhardt, Anna Docherty, Alexis Edwards, Pierre Fontanillas, Jerome Foo, Josef Frank, Ina Giegling, Scott Gordon, Laura Hack, Annette Hartmann, Sarah Hartz, Stefanie Heilmann-Heimbach, Stefan Herms, Colin Hodgkinson, Per Hoffman, Jouke Hottenga, Martin Kennedy, Mervi Alanne-Kinnunen, Bettina Konte, Jari Lahti, Marius Lahti-Pulkkinen, Lannie Ligthart, Anu Loukola, Brion Maher, Hamdi Mbarek, Andrew McIntosh, Matthew McQueen, Jacquelyn Meyers, Yuri Milaneschi, Teemu Palviainen, John Pearson, Roseann Peterson, Samuli Ripatti, Euijung Ryu, Nancy Saccone, Jessica Salvatore, Melanie Schwandt, Fabian Streit, Jana Strohmaier, Nathaniel Thomas, Jen-Chyong Wang, Bradley Webb, Amanda Wills, Jason Boardman, Danfeng Chen, Doo-Sup Choi, William Copeland, Robert Culverhouse, Norbert Dahmen, Benjamin Domingue, Sarah Elson, Mark Frye, Wolfgang Gäbel, Caroline Hayward, Marcus Ising, Margaret Keyes, Falk Kiefer, John Kramer, Samuel Kuperman, Susanne Lucae, Michael Lynskey, Wolfgang Maier, Karl Mann, Satu Männistö, Bertram Müller-Myhsok, Alison Murray, John Nurnberger, Aarno Palotie, Ulrich Preuss, Katri Räikkönen, Maureen Reynolds, Monika Ridinger, Norbert Scherbaum, Marc Schuckit, Michael Soyka, Jens Treutlein, Stephanie Witt, Norbert Wodarz, Peter Zill, Daniel Adkins, Dorret Boomsma, Laura Bierut, Sandra Brown, Kathleen Bucholz, Sven Cichon, E. Jane Costello, Harriet de Wit, Nancy Diazgranados, Danielle Dick, Johan Eriksson, Lindsay Farrer, Tatiana Foroud, Nathan Gillespie, Alison Goate, David Goldman, Richard Grucza, Dana Hancock, Andrew Heath, John Hewitt, Christian Hopfer, William Iacono, Eric Johnson, Jaakko Kaprio, Victor Karpyak, Kenneth Kendler, Henry Kranzler, Paul Lichtenstein, Penelope Lind, Matt McGue, James MacKillop, Pamela Madden, Hermine Maes, Patrik Magnusson, Nicholas Martin, Sarah Medland, Grant Montgomery, Elliot Nelson, Markus Nöthen, Abraham Palmer, Nancy Pederson, Brenda Penninx, John Rice, Marcella Rietschel, Brien Riley, Richard Rose, Dan Rujescu, Pei-Hong Shen, Judy Silberg, Michael Stallings, Ralph Tarter, Michael Vanyukov, Tamara Wall, John Whitfield, Hongyu Zhao, Benjamin Neale, Howard Edenberg

Publikováno v: Johnson, E, Hottenga, J, Ligthart, L, Mbarek, H, Milaneschi, Y, Boomsma, D, Agrawal, A & Psychiatric Genomics Consortium Substance Use Disorders Workgroup 2020, ' A large-scale genome-wide association study meta-analysis of cannabis use disorder ', The Lancet Psychiatry, vol. 7, no. 12, pp. 1032-1045 . https://doi.org/10.1016/S2215-0366(20)30339-4
Johnson, E C, Demontis, D, Thorgeirsson, T E, Walters, R K, Polimanti, R, Hatoum, A S, Sanchez-Roige, S, Paul, S E, Wendt, F R, Clarke, T-K, Lai, D, Reginsson, G W, Zhou, H, He, J, Baranger, D A A, Gudbjartsson, D F, Wedow, R, Adkins, D E, Adkins, A E, Alexander, J, Bacanu, S-A, Bigdeli, T B, Boden, J, Brown, S A, Bucholz, K K, Bybjerg-Grauholm, J, Corley, R P, Degenhardt, L, Dick, D M, Domingue, B W, Fox, L, Goate, A M, Gordon, S D, Hack, L M, Hancock, D B, Hartz, S M, Hickie, I B, Hougaard, D M, Krauter, K, Lind, P A, McClintick, J N, McQueen, M B, Meyers, J L, Montgomery, G W, Mors, O, Mortensen, P B, Nordentoft, M, Pearson, J F, Peterson, R E, Børglum, A D & Psychiatric Genomics Consortium Substance Use Disorders Workgroup 2020, ' A large-scale genome-wide association study meta-analysis of cannabis use disorder ', The Lancet Psychiatry, vol. 7, no. 12, pp. 1032-1045 . https://doi.org/10.1016/S2215-0366(20)30339-4
The Lancet Psychiatry, 7(12), 1032-1045. Elsevier Limited
The Lancet. Psychiatry
Johnson, E C, Demontis, D, Thorgeirsson, T E, Walters, R, Polimanti, R, Hatoum, A S, Sanchez-roige, S, Paul, S E, Wendt, F R, Clarke, T, Lai, D, Reginsson, G W, Zhou, H, He, J, Baranger, D A A, Gudbjartsson, D F, Wedow, R, Adkins, D, Adkins, A, Alexander, J, Bacanu, S, Bigdeli, T B, Boden, J, Brown, S A, Bucholz, K, Bybjerg-grauholm, J, Corley, R P, Degenhardt, L, Dick, D, Domingue, B, Fox, L, Goate, A M, Gordon, S, Hack, L, Hancock, D, Hartz, S, Hickie, I B, Hougaard, D M, Krauter, K, Lind, P, Mcclintick, J, Mcqueen, M, Meyers, J, Montgomery, G, Mors, O, Mortensen, P B, Nordentoft, M, Pearson, J F, Peterson, R, Reynolds, M, Rice, J, Runarsdottir, V, Saccone, N, Sherva, R, Silberg, J L, Tarter, R, Tyrfingsson, T, Wall, T, Webb, B, Werge, T, Wetherill, L, Wright, M J, Zellers, S, Adams, M J, Bierut, L, Boardman, J, Copeland, W, Farrer, L, Foroud, T M, Gillespie, N A, Grucza, R A, Harris, K M, Heath, A, Hesselbrock, V, Hewitt, J, Hopfer, C, Horwood, J, Iacono, W G, Johnson, E, Kendler, K, Kennedy, M, Kranzler, H, Madden, P A F, Maes, H, Maher, B, Martin, N G, Mcgue, M, Mcintosh, A M, Medland, S, Nelson, E C, Porjesz, B, Riley, B, Stallings, M, Vanyukov, M, Vrieze, S, Davis, L K, Bogdan, R, Gelernter, J, Edenberg, H, Stefansson, K, Børglum, A D, Agrawal, A, Walters, R, Polimanti, R, Johnson, E, Mcclintick, J, Hatoum, A, He, J, Wendt, F, Zhou, H, Adkins, A, Aliev, F, Bacanu, S, Batzler, A, Bertelsen, S, Biernacka, J, Bigdeli, T, Chen, L, Clarke, T, Chou, Y, Degenhardt, F, Docherty, A, Edwards, A, Fontanillas, P, Foo, J, Fox, L, Frank, J, Giegling, I, Gordon, S, Hack, L, Hartmann, A, Hartz, S, Heilmann-heimbach, S, Herms, S, Hodgkinson, C, Hoffman, P, Hottenga, J, Kennedy, M, Alanne-kinnunen, M, Konte, B, Lahti, J, Lahti-pulkkinen, M, Lai, D, Ligthart, L, Loukola, A, Maher, B, Mbarek, H, Mcintosh, A M, Mcqueen, M, Meyers, J, Milaneschi, Y, Palviainen, T, Pearson, J, Peterson, R, Ripatti, S, Ryu, E, Saccone, N, Salvatore, J, Sanchez-roige, S, Schwandt, M, Sherva, R, Streit, F, Strohmaier, J, Thomas, N, Wang, J, Webb, B, Wedow, R, Wetherill, L, Wills, A, Boardman, J, Chen, D, Choi, D, Copeland, W, Culverhouse, R, Dahmen, N, Degenhardt, L, Domingue, B, Elson, S, Frye, M, Gäbel, W, Hayward, C, Ising, M, Keyes, M, Kiefer, F, Kramer, J, Kuperman, S, Lucae, S, Lynskey, M, Maier, W, Mann, K, Männistö, S, Müller-myhsok, B, Murray, A, Nurnberger, J, Palotie, A, Preuss, U, Räikkönen, K, Reynolds, M, Ridinger, M, Scherbaum, N, Schuckit, M, Soyka, M, Treutlein, J, Witt, S, Wodarz, N, Zill, P, Adkins, D, Boden, J, Boomsma, D, Bierut, L, Brown, S, Bucholz, K, Cichon, S, Costello, E J, De Wit, H, Diazgranados, N, Dick, D, Eriksson, J, Farrer, L, Foroud, T, Gillespie, N, Goate, A, Goldman, D, Grucza, R, Hancock, D, Harris, K M, Heath, A, Hesselbrock, V, Hewitt, J, Hopfer, C, Horwood, J, Iacono, W, Johnson, E, Kaprio, J, Karpyak, V, Kendler, K, Kranzler, H, Krauter, K, Lichtenstein, P, Lind, P, Mcgue, M, Mackillop, J, Madden, P, Maes, H, Magnusson, P, Martin, N, Medland, S, Montgomery, G, Nelson, E, Nöthen, M, Palmer, A, Pederson, N, Penninx, B, Porjesz, B, Rice, J, Rietschel, M, Riley, B, Rose, R, Rujescu, D, Shen, P, Silberg, J, Stallings, M, Tarter, R, Vanyukov, M, Vrieze, S, Wall, T, Whitfield, J, Zhao, H, Neale, B, Gelernter, J, Edenberg, H & Agrawal, A 2020, ' A large-scale genome-wide association study meta-analysis of cannabis use disorder ', The Lancet Psychiatry, vol. 7, no. 12, pp. 1032-1045 . https://doi.org/10.1016/S2215-0366(20)30339-4
Johnson, E C, Demontis, D, Thorgeirsson, T E, Walters, R K, Polimanti, R, Hatoum, A S, Sanchez-Roige, S, Paul, S E, Wendt, F R, Clarke, T K, Lai, D, Reginsson, G W, Zhou, H, He, J, Baranger, D A A, Gudbjartsson, D F, Wedow, R, Adkins, D E, Adkins, A E, Alexander, J, Bacanu, S A, Bigdeli, T B, Boden, J, Brown, S A, Bucholz, K K, Bybjerg-Grauholm, J, Corley, R P, Degenhardt, L, Dick, D M, Domingue, B W, Fox, L, Goate, A M, Gordon, S D, Hack, L M, Hancock, D B, Hartz, S M, Hickie, I B, Hougaard, D M, Krauter, K, Lind, P A, McClintick, J N, McQueen, M B, Meyers, J L, Montgomery, G W, Mors, O, Mortensen, P B, Nordentoft, M, Pearson, J F, Peterson, R E, Werge, T & Psychiatric Genomics Consortium Substance Use Disorders Workgroup 2020, ' A large-scale genome-wide association study meta-analysis of cannabis use disorder ', The Lancet Psychiatry, vol. 7, no. 12, pp. 1032-1045 . https://doi.org/10.1016/S2215-0366(20)30339-4
Psychiatric Genomics Consortium Substance Use Disorders Workgroup 2020, ' A large-scale genome-wide association study meta-analysis of cannabis use disorder ', The Lancet Psychiatry, vol. 7, no. 12, pp. 1032-1045 . https://doi.org/10.1016/S2215-0366(20)30339-4
The Lancet Psychiatry

Background: Variation in liability to cannabis use disorder has a strong genetic component (estimated twin and family heritability about 50–70%) and is associated with negative outcomes, including increased risk of psychopathology. The aim of the s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5e1394595d95a3f48eb1610651d6d82
https://doi.org/10.1016/s2215-0366(20)30339-4

Toxoplasma gondii lysine acetyltransferase GCN5-A functions in the cellular response to alkaline stress and expression of cyst genes.

Autor: Arunasalam Naguleswaran, Eliana V Elias, Jeanette McClintick, Howard J Edenberg, William J Sullivan

Publikováno v: PLoS Pathogens, Vol 6, Iss 12, p e1001232 (2010)

Parasitic protozoa such as the apicomplexan Toxoplasma gondii progress through their life cycle in response to stimuli in the environment or host organism. Very little is known about how proliferating tachyzoites reprogram their expressed genome in r

Externí odkaz: https://doaj.org/article/cc7a2460103a4c898792691bfabd93b8